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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC6796 (±)-Anatoxin A fumarate
BCC6695 BP 554 maleate Selective 5-HT_1A agonist
BCC6180 MFZ 10-7
BCC5289 ATB-346 ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
BCC7887 SB 277011A dihydrochloride SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
BCC5113 4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
BCC6471 AZD3839 AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
BCC7772 A 943931 dihydrochloride Potent and selective H₄ antagonist
BCC1342 Alosetron Alosetron (GR 68755) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
BCC1343 Alosetron (Z)-2-butenedioate Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
BCC1344 Alosetron Hydrochloride Alosetron Hydrochloride (GR 68755 Hydrochloride) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
BCC2511 Ziprasidone HCl Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
BCC5035 Azasetron HCl Azasetron (hydrochloride) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
BCC1900 Rivastigmine Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
BCC7318 PNU 282987 PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
BCC4565 Biperiden HCl Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
BCC7314 AQ-RA 741 Selective, high affinity M₂ antagonist
BCC1641 Iguratimod Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
BCC1239 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
BCC4054 (R)-(+)-Tolterodine Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
BCC4586 Tolterodine tartrate Tolterodine Tartrate (Kabi-2234; PNU-200583E) is a potent muscarinic receptor antagonist and shows selectivity for the urinary bladder over salivary glands in vivo.
BCC7901 TCN 238 TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
BCC5251 Sibutramine hydrochloride monohydrate Sibutramine hydrochloride monohydrate is a novel 5-HT (serotonin) and noradrenaline reuptake inhibitor (SNRI). The IC50 for Sibutramine block of voltage-gated K+ channel (KV)4.3 is 17.3 μM.
BCC1908 Rotigotine hydrochloride Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
BCC7793 RuBi-Nicotine
BCC7652 NPEC-caged-(S)-3,4-DCPG
BCC7837 NPEC-caged-dopamine
BCC7818 GSK 789472 hydrochloride
BCC1040 Parathyroid Hormone (1-34), bovine
BCC7642 VU 0155041 sodium salt
BCC6849 SCH 23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
BCC3807 LY2886721 LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.
BCC7759 DL-AP4 Sodium salt
BCC7418 Zamifenacin fumarate Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome.
BCC6159 VU 0360223
BCC4193 Escitalopram Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
BCC4516 Buclizine HCl Buclizine HCl is an antihistamine and anticholinergic of the piperazine derivative family.
BCC3851 Rivastigmine Tartrate Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
BCC5802 GR 82334
BCC5034 Aripiprazole Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
BCC5064 Dapoxetine HCl Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor(SSRI).
BCC4212 Iloperidone hydrochloride Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
BCC7755 CHPG Sodium salt CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..
BCC7756 (RS)-MCPG disodium salt
BCC7104 A 68930 hydrochloride Potent, selective D₁-like agonist
BCC5549 Decloxizine dihydrochloride Decloxizine dihydrochloride(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.
BCC6141 VU 0360172 hydrochloride
BCC6150 TC-N 22A
BCC1045 Amyloid Beta-Peptide (1-40) (human) β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
BCC1246 Scrambled 10Panx Scrambled version of ¹⁰Panx, Panx-1 mimetic inhibitory peptide
BCC7653 NPEC-caged-(1S,3R)-ACPD
BCC1027 Amyloid Beta-peptide (25-35) (human) Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
BCC7263 DAU 5884 hydrochloride
BCC4524 Benztropine mesylate Benzatropine mesylate is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.
BCC1345 Alosetron-d3 Hydrochloride Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.
BCC5042 Olanzapine Olanzapine is a selective monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic.
BCC7509 CP 96345
BCC3740 Blonanserin Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic.
BCC1516 Darifenacin Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
BCC4567 Darifenacin HBr Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
BCC5801 GR 73632 GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.
BCC2516 Iloperidone Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
BCC6927 (-)-Lobeline hydrochloride Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
BCC6598 (RS)-4-Carboxy-3-hydroxyphenylglycine
BCC6603 (S)-4-Carboxyphenylglycine
BCC6224 A 412997 dihydrochloride Selective D₄ agonist
BCC6634 N-Acetylglycyl-D-glutamic acid
BCC1834 Palonosetron Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
BCN2171 Palonosetron hydrochloride Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
BCC7134 RP 67580
BCC7061 (S)-(+)-Dimethindene maleate
BCC2000 Tiotropium Bromide Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
BCC3773 Duloxetine HCl Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
BCC1084 Lidocaine Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative commonly used to anesthetize. Lidocaine is a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.
BCC4438 Tolfenamic Acid Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
BCN2165 Agomelatine Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
BCC6343 ML 289
BCC5907 FK 888
BCC6606 (R)-3-Carboxy-4-hydroxyphenylglycine
BCC2072 Ziprasidone hydrochloride monohydrate Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
BCC5062 Zolmitriptan Zolmitriptan is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.
BCC4585 Tiotropium Bromide hydrate Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.
BCC7427 Milameline hydrochloride
BCC6845 3-CPMT
BCC4545 Olopatadine HCl Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.
BCC6761 Aminopotentidine
BCC4146 Xanomeline oxalate Xanomeline oxalate (LY246708 oxalate) is a selective M1 muscarinic receptor agonist.
BCC1371 Asenapine hydrochloride Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.
BCC1969 ST-836 hydrochloride
BCC5935 Catestatin
BCC6744 Amthamine dihydrobromide
BCC5053 Naratriptan Naratriptan hydrochloride is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.
BCC1906 Rocuronium Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
BCC6615 1-Acetyl-4-methylpiperazine hydrochloride
BCC6345 ML 337
BCC3834 Paliperidone Paliperidone (9-hydroxyrisperidone) is a dopamine antagonist of the atypical antipsychotic class of medications.
BCC4154 ML314 ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.
BCN6255 Pregnenolone Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication.
BCC6898 Piribedil dihydrochloride
BCC6800 8-Hydroxy-PIPAT oxalate