Search Site
Home >> Research Area >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a base missing from the backbone of DNA, or a chemically changed base as 8-OHdG. Damage to DNA that occurs naturally can result from metabolic or hydrolytic processes. Metabolism releases compounds that damage DNA including reactive oxygen species, reactive nitrogen species, reactive carbonyl species, lipid peroxidation products and alkylating agents, among others, while hydrolysis cleaves chemical bonds in DNA.DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.

Products for DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. BCN1225 (S)-10-Hydroxycamptothecin (S)-10-Hydroxycamptothecin
  3. BCN5918 4'-Demethylepipodophyllotoxin 4'-Demethylepipodophyllotoxin
  4. BCN5796 Adenosine Endogenous adenosine receptor agonist Adenosine
  5. BCN4318 Camptothecin DNA topoisomerase inhibitor Camptothecin
  6. BCN2168 Capecitabine Capecitabine
  7. BCN5740 Costunolide Inhibitor of human telomerase activity Costunolide
  8. BCN3415 Cytidine Cytidine
  9. BCN5533 Ellagic acid Ellagic acid
  10. BCN5499 Genistein Estrogen receptor ligand. Also tyrosine kinase inhibitor Genistein
  11. BCN2604 Topotecan hydrochloride Topotecan hydrochloride
  12. BCN4090 Uridine Uridine
  13. BCC1057 Daptomycin Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria Daptomycin
  14. BCC1064 Gatifloxacin Antibiotic; activates short-term renewal of ESCs Gatifloxacin
  15. BCC1072 Nelarabine Prodrug of ara-G for T-LBL/T-ALL Nelarabine
  16. BCC1076 Gemcitabine HCl Ribonucleotide reductase inhibitor Gemcitabine HCl
  17. BCC1078 Clofarabine Deoxycytidine kinase (dCK) substrate Clofarabine
  18. BCC1087 Dexrazoxane HCl (ICRF-187, ADR-529) Topoisomerase II inhibitor,intracellular ion chelator,cardioprotective agent Dexrazoxane HCl (ICRF-187, ADR-529)
  19. BCC1117 Doxorubicin (Adriamycin) HCl Antitumor antibiotic agent; induces apoptosis Doxorubicin (Adriamycin) HCl
  20. BCC1120 XAV-939 Tankyrase inhibitor; promotes cardiomyogenesis XAV-939
  21. BCC1147 BIBR 1532 Selective telomerase inhibitor BIBR 1532
  22. BCC1151 Etoposide Topoisomerase II inhibitor Etoposide
  23. BCC1164 Ifosfamide Cytostatic agent Ifosfamide
  24. BCC1170 Carboplatin DNA cross-linking antitumor agent Carboplatin
  25. BCC1173 Cladribine Deoxyadenosine analog; pro-apoptotic Cladribine
  26. BCC1174 Dacarbazine Antineoplastic( malignant melanoma and sarcomas) Dacarbazine
  27. BCC1185 Cyclophosphamide Alkylating agent; chemotherapeutic Cyclophosphamide
  28. BCC1186 Mercaptopurine (6-MP) Purine analog; inhibits DNA and RNA synthesis Mercaptopurine (6-MP)
  29. BCC1187 Floxuridine Inhibitor of thymidylate synthetase; anticancer agent Floxuridine
  30. BCC1192 Epirubicin HCl Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II Epirubicin HCl
  31. BCC1194 Idarubicin HCl Anthracycline and daunorubicin analog,topoisomerase inhibitor Idarubicin HCl
  32. BCC1214 Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent Carmofur
  33. BCC1216 Altretamine Antineoplastic agent Altretamine
  34. BCC1249 Amonafide DNA intercalator,Topo II inhibitor Amonafide
  35. BCC1256 Leflunomide Dihydroorotate dehydrogenase inhibitor Leflunomide
  36. BCC1325 Abacavir Inhibitor of HIV reverse transcriptase Abacavir
  37. BCC1389 AZ20 Potent and selective ATR kinase inhibitor; antitumor AZ20
  38. BCC1476 CHAPS Zwitterionic detergent for membrane proteins,nondenaturing CHAPS
  39. BCC1514 Daminozide Selective KDM2/7 inhibitor Daminozide
  40. BCC1521 Deferasirox Fe3+ chelate Oral iron chelator Deferasirox Fe3+ chelate
  41. BCC1537 DOXO-EMCH Prodrug of doxorubicin DOXO-EMCH
  42. BCC1592 Genz-644282 Non-camptothecin inhibitor of topoisomerase I Genz-644282
  43. BCC1651 INNO-206 Prodrug of doxorubicin INNO-206
  44. BCC1833 Palifosfamide Active metabolite of ifosfamide (IFOS) Palifosfamide
  45. BCC1837 Paradol Active flavor constituent of the seeds of Guinea pepper Paradol
  46. BCC1871 PSI-7977 Antiviral agents for chronic HCV infection PSI-7977
  47. BCC1888 Resminostat hydrochloride HDAC inhibitor Resminostat hydrochloride
  48. BCC1893 RG2833 Brain-penetrant HDAC inhibitor RG2833
  49. BCC1987 Tasquinimod Antiangiogenic and antineoplastic agent Tasquinimod
  50. BCC1998 TH-302 Hypoxia-activated prodrug,inhibits H460/HT29 cell growth TH-302
  51. BCC2024 VAL-083 Bi-functional alkylating agent VAL-083
  52. BCC2044 Voreloxin Topo II inhibitor Voreloxin
  53. BCC2045 Voreloxin Hydrochloride Antineoplastic naphthyridine analogue Voreloxin Hydrochloride
  54. BCC2082 Doxorubicin Topo II inhibitor,immunosuppresive antineoplastic antibiotic Doxorubicin
  55. BCC2144 Rocilinostat (ACY-1215) Selective HDAC6 inhibitor Rocilinostat (ACY-1215)
  56. BCC2145 Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor Vorinostat (SAHA, MK0683)
  57. BCC2146 Mocetinostat (MGCD0103, MG0103) HDAC inhibitor,isotype-selective and potent Mocetinostat (MGCD0103, MG0103)
  58. BCC2147 JNJ-26481585 Potent HDAC inhibitor JNJ-26481585
  59. BCC2148 PCI-34051 Potent and selective HDAC8 inhibitor PCI-34051
  60. BCC2149 CUDC-101 Multitargeted HDAC inhibitor CUDC-101
  61. BCC2150 ITF2357 (Givinostat) HDAC inhibitor ITF2357 (Givinostat)
  62. BCC2151 MC1568 Selective HDAC class II (IIa) inhibitor MC1568
  63. BCC2152 Pracinostat (SB939) Pan-HDAC inhibitor Pracinostat (SB939)
  64. BCC2153 Belinostat (PXD101) Hydroxamate-type HDAC inhibitor Belinostat (PXD101)
  65. BCC2155 PCI-24781 (CRA-024781) Pan-HDAC inhibitor PCI-24781 (CRA-024781)
  66. BCC2156 Valproic acid sodium salt (Sodium valproate) Histone deacetylase inhibitor; enables induction of pluripotent stem cells from somatic cells Valproic acid sodium salt (Sodium valproate)
  67. BCC2157 Droxinostat Selective HDAC inhibitor Droxinostat
  68. BCC2158 Tubastatin A HDAC6 inhibitor,potent and selective Tubastatin A
  69. BCC2159 CI994 (Tacedinaline) HDAC inhibitor CI994 (Tacedinaline)
  70. BCC2160 LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel LAQ824 (NVP-LAQ824,Dacinostat)
  71. BCC2161 AR-42 (OSU-HDAC42) HDAC inhibitor,novel and potent AR-42 (OSU-HDAC42)
  72. BCC2162 M344 Histone deacetylase inhibitor M344
  73. BCC2163 Scriptaid Histone deacetylase inhibitor Scriptaid
  74. BCC2164 Sodium Phenylbutyrate Histone deacetylase inhibitor Sodium Phenylbutyrate
  75. BCC2165 Resminostat (RAS2410) Potent HDAC inhibitor Resminostat (RAS2410)
  76. BCC2205 BMN 673 Potent PARP inhibitor BMN 673
  77. BCC2209 AG-14361 Potent PARP1 inhibitor AG-14361
  78. BCC2220 Thioguanine Anticancer and immunosuppressive agent; disrupts cytosine methylation Thioguanine
  79. BCC2420 KD 5170 HDAC inhibitor KD 5170
  80. BCC2421 LMK 235 Selective HDAC4/HDAC5 inhibitor LMK 235
  81. BCC2422 NCH 51 Histone deacetylase inhibitor NCH 51
  82. BCC2423 NSC 3852 Histone deacetylase inhibitor NSC 3852
  83. BCC2424 Pyroxamide Histone deacetylase inhibitor Pyroxamide
  84. BCC2425 SBHA Histone deacetylase inhibitor SBHA
  85. BCC2426 TC-H 106 Class I histone deacetylase inhibitor TC-H 106
  86. BCC2427 TCS HDAC6 20b Selective HDAC6 inhibitor TCS HDAC6 20b
  87. BCC2428 Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable Tubacin
  88. BCC2475 KU 55933 Potent and selective ATM kinase inhibitor KU 55933
  89. BCC2490 Irinotecan Topoisomerase I inhibitor Irinotecan
  90. BCC2507 Moxifloxacin HCl Fluoroquinolone antibiotic Moxifloxacin HCl
  91. BCC2518 Fludarabine Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression Fludarabine
  92. BCC2526 Ofloxacin Fluoroquinolones,antibiotics Ofloxacin
  93. BCC3595 Entinostat (MS-275,SNDX-275) HDAC1 and HDAC3 inhibitor Entinostat (MS-275,SNDX-275)
  94. BCC3597 Romidepsin (FK228, depsipeptide) Potent and selective class I histone deacetylase inhibitor; antitumor Romidepsin (FK228, depsipeptide)
  95. BCC3599 Apicidin Potent histone deacetylase inhibitor Apicidin
  96. BCC3601 Panobinostat (LBH589) HDAC inhibitor Panobinostat (LBH589)
  97. BCC3605 Trichostatin A (TSA) Potent histone deacetylase inhibitor; induces accelerated dedifferentiation of primordial germ cells Trichostatin A (TSA)
  98. BCC3640 Amrubicin Topoisomerase II inhibitor, anthracycline agent Amrubicin
  99. BCC3681 Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis Fludarabine Phosphate (Fludara)
  100. BCC3694 Bleomycin Sulfate Chemotherapy agent, induces DNA strand break Bleomycin Sulfate
  101. BCC3699 KU-60019 ATM kinase inhibitor,potent and selective KU-60019

Items 1 to 100 of 175 total

       
  1. 1
  2. 2
  3.  
  4.  
  5. Last