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Proteases/Proteasome

Proteasomes are protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, proteasomes are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein. NF-

Products for Proteases/Proteasome

  1. Cat.No. Product Name Information
  2. BCC1127 E 64d Cathepsin inhibitor; interferes with autolysosomal digestion E 64d
  3. BCC1141 CA 074 Selective cathepsin B inhibitor CA 074
  4. BCC1197 Odanacatib (MK-0822) Cathepsin K,potent and selective Odanacatib (MK-0822)
  5. BCC1217 Leupeptin, Microbial Inhibits trypsin-like/cysteine proteases Leupeptin, Microbial
  6. BCC1218 Pepstatin A Aspartic protease inhibitor Pepstatin A
  7. BCC1219 AEBSF.HCl Broad spectrum, irreversible inhibitor of serine proteases AEBSF.HCl
  8. BCC1220 Aprotinin Competitive serine protease inhibitor Aprotinin
  9. BCC1221 Bestatin Aminopeptidase inhibitor Bestatin
  10. BCC1222 E-64 Potent and irreversible cysteine protease inhibitor E-64
  11. BCC1223 Batimastat (BB-94) Potent, broad spectrum MMP inhibitor Batimastat (BB-94)
  12. BCC1228 Nafamostat Mesylate(FUT-175) Serine protease inhibitor, inhibits tryptase Nafamostat Mesylate(FUT-175)
  13. BCC1229 PMSF Non-selective protease inhibitor; also blocks anandamide metabolism PMSF
  14. BCC1230 Vicriviroc Malate CCR5 antagonist, orally active, second generation Vicriviroc Malate
  15. BCC1233 Calpain Inhibitor I, ALLN Calpain inhibitor; activates p53-dependent apoptosis Calpain Inhibitor I, ALLN
  16. BCC1234 Calpain Inhibitor II, ALLM Cathepsin inhibitor Calpain Inhibitor II, ALLM
  17. BCC1287 P005091 USP7 inhibitor P005091
  18. BCC1297 17-AAG Hydrochloride Hsp90 inhibitor,geldanamycin analogue 17-AAG Hydrochloride
  19. BCC1313 5-R-Rivaroxaban Factor Xa (FXa) inhibitor 5-R-Rivaroxaban
  20. BCC1341 Alogliptin Benzoate DPP-4 inhibitor,selective and potent,antidiabetic drug Alogliptin Benzoate
  21. BCC1346 Alvespimycin Hsp90 inhibitor,potent and selective Alvespimycin
  22. BCC1365 Anguizole Inhibitor of HCV replication Anguizole
  23. BCC1374 Asunaprevir (BMS-650032) NS3 protease inhibitor Asunaprevir (BMS-650032)
  24. BCC1396 Balapiravir Polymerase inhibitor,anti-HCV Balapiravir
  25. BCC1413 BCX 1470 Serine protease inhibitor BCX 1470
  26. BCC1414 BCX 1470 methanesulfonate Serine protease inhibitor BCX 1470 methanesulfonate
  27. BCC1421 Bivalirudin Trifluoroacetate Reversible thrombin inhibitor Bivalirudin Trifluoroacetate
  28. BCC1427 BMS-626529 HIV-1 attachment inhibitor BMS-626529
  29. BCC1431 BMS-790052 dihydrochloride HCV NS5A inhibitor BMS-790052 dihydrochloride
  30. BCC1435 Boceprevir HCV protease inhibitor,potent and selective Boceprevir
  31. BCC1455 Cathepsin S inhibitor Blocks MHCII antigen presentation Cathepsin S inhibitor
  32. BCC1482 Ciluprevir (BILN-2061) Inhibitor of HCV NS3 protease Ciluprevir (BILN-2061)
  33. BCC1502 CTS-1027 MMPs inhibitor CTS-1027
  34. BCC1511 Dabigatran etexilate mesylate Direct thrombin inhibitor,anticoagulant,prodrug of dabigatran Dabigatran etexilate mesylate
  35. BCC1512 Dabigatran ethyl ester Thrombin activity inhibitor Dabigatran ethyl ester
  36. BCC1540 E 2012 γ--Secretase modulator E 2012
  37. BCC1543 Edoxaban Factor Xa inhibitor Edoxaban
  38. BCC1544 Edoxaban tosylate Fxa inhibitor Edoxaban tosylate
  39. BCC1545 Edoxaban tosylate monohydrate Oral factor Xa inhibitor Edoxaban tosylate monohydrate
  40. BCC1581 Fosamprenavir Calcium Salt Prodrug of antiretroviral protease inhibitor amprenavir Fosamprenavir Calcium Salt
  41. BCC1583 gamma-secretase modulator 1 Useful for Alzheimer's disease. gamma-secretase modulator 1
  42. BCC1584 gamma-secretase modulator 2 Attenuate Aβ production in Alzheimer's Disease gamma-secretase modulator 2
  43. BCC1585 gamma-secretase modulator 3 Modulator of gamma-secretase gamma-secretase modulator 3
  44. BCC1618 HIV-1 integrase inhibitor Uesful for anti-HIV HIV-1 integrase inhibitor
  45. BCC1619 HIV-1 integrase inhibitor 2 HIV-1 integrase inhibitor HIV-1 integrase inhibitor 2
  46. BCC1762 MK-5172 HCV NS3/4a protease inhibitor MK-5172
  47. BCC1763 MK-5172 hydrate HCV NS3/4a protease inhibitor MK-5172 hydrate
  48. BCC1764 MK-5172 potassium salt HCV NS3/4a protease inhibitor MK-5172 potassium salt
  49. BCC1765 MK-5172 sodium salt HCV NS3/4a protease inhibitor MK-5172 sodium salt
  50. BCC1785 Narlaprevir HCV NS3 protease inhibitor Narlaprevir
  51. BCC1794 Nelfinavir Mesylate Potent HIV-1 protease inhibitor Nelfinavir Mesylate
  52. BCC1796 Nesbuvir NS5B polymerase inhibitor Nesbuvir
  53. BCC1827 Otamixaban Direct factor Xa inhibitors,potent and selective Otamixaban
  54. BCC1848 PF-03084014 γ-secretase inhibitor PF-03084014
  55. BCC1870 PSI-6130 Inhibitor of HCV nucleoside polymerase,selective and effective PSI-6130
  56. BCC1872 PU-H71 Hsp90 inhibitor,potent and selective PU-H71
  57. BCC1889 Retaspimycin HSP90 inhibitor,antiproliferative and antineoplastic Retaspimycin
  58. BCC1904 RO-9187 HCV virus replication inhibitor RO-9187
  59. BCC1921 Saquinavir HIV Protease Inhibitor Saquinavir
  60. BCC1922 Saquinavir mesylate HIV Protease Inhibitor Saquinavir mesylate
  61. BCC1949 Simeprevir Inhibitor of HCV NS3/4A protease Simeprevir
  62. BCC1952 SJB2-043 USP1 inhibitor SJB2-043
  63. BCC1991 Tegobuvir HCV RNA replication inhibitor Tegobuvir
  64. BCC1992 Teneligliptin hydrobromide Dipeptidyl peptidase-4 inhibitor Teneligliptin hydrobromide
  65. BCC2002 Tipranavir HIV protease inhibitor Tipranavir
  66. BCC2014 Trelagliptin DPP-4 inhibitor,long-acting and selective Trelagliptin
  67. BCC2015 Trelagliptin succinate DPP-4 inhibitor Trelagliptin succinate
  68. BCC2030 Vaniprevir Hepatitis C virus NS3/4a protease inhibitor Vaniprevir
  69. BCC2075 Batimastat sodium salt Anticancer drug Batimastat sodium salt
  70. BCC2086 IU1 USP14 inhibitor IU1
  71. BCC2087 LDN 57444 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor LDN 57444
  72. BCC2088 NSC 632839 hydrochloride Inhibitor of ubiquitin isopeptidase activity NSC 632839 hydrochloride
  73. BCC2089 RO4929097 γ secretase inhibitor RO4929097
  74. BCC2090 MK-0752 γ-secretase inhibitor MK-0752
  75. BCC2100 YO-01027 (Dibenzazepine, DBZ) γ-secretase inhibitor YO-01027 (Dibenzazepine, DBZ)
  76. BCC2101 LY-411575 Gamma secretase inhibitor LY-411575
  77. BCC2102 LY2811376 Non-peptidic BACE1 inhibitor LY2811376
  78. BCC2103 LY-900009 Potent Notch inhibitor LY-900009
  79. BCC2104 BMS-708163 (Avagacestat) γ-secretase inhibitor BMS-708163 (Avagacestat)
  80. BCC2105 LY3039478 Notch inhibitor, novel and potent LY3039478
  81. BCC2106 Danoprevir (RG7227) HCV NS3/4A protease inhibitor Danoprevir (RG7227)
  82. BCC2107 Telaprevir (VX-950) HCV NS3-4A protease inhibitor Telaprevir (VX-950)
  83. BCC2108 VX-222 (VCH-222, Lomibuvir) NNI of HCV RNA polymerase VX-222 (VCH-222, Lomibuvir)
  84. BCC2109 Glimepiride Kir6 (KATP) channel blocker Glimepiride
  85. BCC2110 Linagliptin (BI-1356) DDP-4 inhibitor,highly potent and competitive Linagliptin (BI-1356)
  86. BCC2111 Sitagliptin phosphate monohydrate Potent DPP-4 inhibitor Sitagliptin phosphate monohydrate
  87. BCC2112 Vildagliptin (LAF-237) DPP-4 inhibitor Vildagliptin (LAF-237)
  88. BCC2113 Alogliptin (SYR-322) DPP-4 inhibitor,potent and highly selective Alogliptin (SYR-322)
  89. BCC2114 Atazanavir sulfate (BMS-232632-05) Protease inhibitor Atazanavir sulfate (BMS-232632-05)
  90. BCC2118 Marimastat Broad spectrum MMP inhibitor Marimastat
  91. BCC2119 GM 6001 Broad spectrum MMP inhibitor GM 6001
  92. BCC2120 NSC 405020 Inhibitor of MT1-MMP; antitumor NSC 405020
  93. BCC2121 17-AAG (KOS953) Selective Hsp90 inhibitor; protects neuroprogenitor cells against stress-induced apoptosis 17-AAG (KOS953)
  94. BCC2122 AT13387 Hsp90 inhibitor AT13387
  95. BCC2123 AUY922 (NVP-AUY922) Potent Hsp90 inhibitor AUY922 (NVP-AUY922)
  96. BCC2124 BIIB021 Hsp90 inhibitor,selective and competitive BIIB021
  97. BCC2125 Geldanamycin Selective Hsp90 inhibitor; breast cancer stem cell inhibitor Geldanamycin
  98. BCC2126 IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective IPI-504 (Retaspimycin hydrochloride)
  99. BCC2127 KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, KW-2478
  100. BCC2129 NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic NVP-BEP800
  101. BCC2130 PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective PF-04929113 (SNX-5422)

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