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MAPK Signaling

The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.

Products for MAPK Signaling

  1. Cat.No. Product Name Information
  2. BCC1042 PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor PKA inhibitor fragment (6-22) amide
  3. BCC1066 U0126-EtOH MEK1/2 inhibitor U0126-EtOH
  4. BCC1079 CEP-32496 BRAF(V600E)inhibitor,highly potent CEP-32496
  5. BCC1093 SB202190 (FHPI) Promotes stability of human PSCs; potent, selective inhibitor of p38 MAPK SB202190 (FHPI)
  6. BCC1098 PD98059 MEK inhibitor; enhances ESC self-renewal PD98059
  7. BCC1112 PD184352 (CI-1040) Selective MEK inhibitor PD184352 (CI-1040)
  8. BCC1123 SL-327 Selective inhibitor of MEK1 and MEK2; brain penetrant SL-327
  9. BCC1148 MEK162 (ARRY-162, ARRY-438162) MEK1/2 inhibitor,potent and selective MEK162 (ARRY-162, ARRY-438162)
  10. BCC1269 Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor Vemurafenib (PLX4032, RG7204)
  11. BCC1277 PD0325901 Selective inhibitor of MEK1/2; enhances generation of iPSCs PD0325901
  12. BCC1280 PLX-4720 BRAF kinase inhibitor PLX-4720
  13. BCC1282 Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective Trametinib (GSK1120212)
  14. BCC1369 AS 602801 Jun Kinase Inhibitor AS 602801
  15. BCC1436 BRAF inhibitor Potent B-raf inhibitor BRAF inhibitor
  16. BCC1437 B-Raf inhibitor A B-Raf inhibitor B-Raf inhibitor
  17. BCC1458 CC-401 hydrochloride JNK inhibitor CC-401 hydrochloride
  18. BCC1459 CC-930 JNK inhibitor,potent and selective CC-930
  19. BCC1468 CEP-32496 hydrochloride B-Raf/C-Raf inhibitor,highly potent CEP-32496 hydrochloride
  20. BCC1491 Cobimetinib Selective MEK inhibitor Cobimetinib
  21. BCC1492 Cobimetinib (racemate) Selective MEK inhibitor Cobimetinib (racemate)
  22. BCC1493 Cobimetinib (R-enantiomer) Selective MEK inhibitor Cobimetinib (R-enantiomer)
  23. BCC1513 Dabrafenib Mesylate (GSK-2118436) Inhibitor of BRAF(V600) mutants Dabrafenib Mesylate (GSK-2118436)
  24. BCC1519 DB07268 JNK1 inhibitor DB07268
  25. BCC1672 JNK-IN-7 Selective JNK inhibitor JNK-IN-7
  26. BCC1673 JNK-IN-8 JNK inhibitor, selective and irreversible JNK-IN-8
  27. BCC1738 MEK inhibitor Potent MEK inhibitor, Antitumor agent MEK inhibitor
  28. BCC1771 MLN 2480 Pan-Raf kinase inhibitor,investigational MLN 2480
  29. BCC1918 Salirasib Ras inhibitor; also induces autophagy Salirasib
  30. BCC1923 SB 239063 P38 MAP kinase inhibitor SB 239063
  31. BCC1935 SCH772984 ERK1 and ERK2 inhibitor SCH772984
  32. BCC1937 SD-06 SD-06
  33. BCC1953 Skepinone-L P38-MAPK inhibitor,potent and selective Skepinone-L
  34. BCC2013 Trametinib DMSO solvate Allosteric MEK1/MEK2 kinase inhibitor Trametinib DMSO solvate
  35. BCC2051 VX-11e ERK inhibitor VX-11e
  36. BCC2061 XMD17-109 ERK-5 inhibitor XMD17-109
  37. BCC2062 XMD8-92 BRD4 inhibitor; also ERK5/BMK1 inhibitor XMD8-92
  38. BCC2474 SP 600125 JNK inhibitor; prevents BMP9-induced osteogenic differentiation of MSCs SP 600125
  39. BCC2482 GDC-0879 Potent B-Raf inhibitor GDC-0879
  40. BCC2528 LY2228820 P38 MAP kinase inhibitor LY2228820
  41. BCC2529 Pimasertib (AS-703026) MEK1/2 inhibitor Pimasertib (AS-703026)
  42. BCC2535 BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective BIRB 796 (Doramapimod)
  43. BCC2539 PD318088 Allosteric MEK1/2 inhibitor, non-ATP competitive PD318088
  44. BCC2549 BIX 02189 Selective MEK5 inhibitor BIX 02189
  45. BCC2550 BIX 02188 MEK5 inhibitor,potent and selective BIX 02188
  46. BCC3624 AZD6244 (Selumetinib) MEK inhibitor AZD6244 (Selumetinib)
  47. BCC3639 TAK-632 Pan-RAF inhibitor,potent and selective TAK-632
  48. BCC3663 SB 203580 Selective inhibitor of p38 MAPK; stimulates neural stem cell proliferation SB 203580
  49. BCC3669 FR 180204 ERK inhibitor FR 180204
  50. BCC3672 PH-797804 P38 MAP kinase inhibitor, potent and selective PH-797804
  51. BCC3730 AZ 628 Potent Raf kinase inhibitor AZ 628
  52. BCC3733 AZD8330 MEK 1/2 inhibitor AZD8330
  53. BCC3875 ZM336372 Potent, selective c-Raf inhibitor ZM336372
  54. BCC3966 VX-745 P38α inhibitor,highly potent and selective VX-745
  55. BCC3967 VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive VX-702
  56. BCC3968 TAK-715 p38 MAPK inhibitor TAK-715
  57. BCC3969 PD 169316 P38 MAPK inhibitor PD 169316
  58. BCC3985 LY3009120 pan-RAF and RAF dimer inhibitor LY3009120
  59. BCC3998 PF-04880594 RAF inhibitor PF-04880594
  60. BCC4024 OTS514 TOPK inhibitor,highly potent OTS514
  61. BCC4025 OTS964 TOPK inhibitor,potent and selective OTS964
  62. BCC4055 Refametinib R enantiomer MEK1/2 allosteric inhibitor Refametinib R enantiomer
  63. BCC4122 VRT752271 ERK1/ERK2 inhibitor VRT752271
  64. BCC4150 GDC-0623 MEK1 inhibitor, potent and ATP-uncompetitive GDC-0623
  65. BCC4171 SB 242235 MAPK inhibitor SB 242235
  66. BCC4182 B-Raf inhibitor 1 B-Raf inhibitor 1
  67. BCC4183 B-Raf inhibitor 1 dihydrochloride B-Raf inhibitor,potent and selective B-Raf inhibitor 1 dihydrochloride
  68. BCC4184 LGX818 RAF inhibitor,potent and selective LGX818
  69. BCC4269 CC-401 JNK inhibitor,ATP-competitive CC-401
  70. BCC4276 Refametinib MEK 1/ MEK 2 inhibitor Refametinib
  71. BCC4293 SB 203580 hydrochloride Specific p38-MAPKs inhibitor SB 203580 hydrochloride
  72. BCC4391 GW5074 Potent, selective c-Raf1 kinase inhibitor GW5074
  73. BCC4392 SB590885 Potent B-Raf inhibitor SB590885
  74. BCC4393 Dabrafenib (GSK2118436) Inhibitor of BRAF(V600) mutants Dabrafenib (GSK2118436)
  75. BCC4587 TAK-733 MEK allosteric site inhibitor TAK-733
  76. BCC4997 H 89 2HCl Protein kinase A inhibitor H 89 2HCl
  77. BCC5135 RO4987655 MEK inhibitor RO4987655
  78. BCC5148 TCS JNK 5a JNK2 and JNK3 inhibitor TCS JNK 5a
  79. BCC5368 Losmapimod p38 MAPK inhibitor, orally active Losmapimod
  80. BCC5439 B-Raf IN 1 B-Raf IN 1
  81. BCC5459 HG6-64-1 HG6-64-1
  82. BCC5615 SB 706504 SB 706504
  83. BCC5773 10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits Cdk1, Cdk2, Cdk3 and Cdk5 10Z-Hymenialdisine
  84. BCC5777 JIP-1 (153-163) JNK-selective inhibitor peptide JIP-1 (153-163)
  85. BCC6084 AMG 548 P38α inhibitor,potent and selective AMG 548
  86. BCC6136 PF-3644022 Potent MK2 inhibitor PF-3644022
  87. BCC6178 Pluripotin Pluripotin
  88. BCC6225 HI TOPK 032 HI TOPK 032
  89. BCC6300 PD 334581 MEK1 inhibitor PD 334581
  90. BCC6371 GDC-0994 ERK1/2 inhibitor GDC-0994
  91. BCC6374 RO5126766(CH5126766) Raf/MEK dual inhibitor RO5126766(CH5126766)
  92. BCC6464 AS601245 c-Jun NH2-terminal protein kinase inhibitor AS601245
  93. BCC6474 PF-03394197(Oclacitinib) Novel Janus kinase inhibitor PF-03394197(Oclacitinib)
  94. BCC6509 Pexmetinib (ARRY-614) dual inhibitor of p38 MAPK and Tie2/Tek receptor tyrosine kinase Pexmetinib (ARRY-614)
  95. BCC6511 BI-847325 dual inhibitor of MEK and Aurora kinases BI-847325
  96. BCC6521 DEL-22379 inhibitor of the dimerization of ERK DEL-22379
  97. BCC7006 KT 5823 Selective protein kinase G inhibitor KT 5823
  98. BCC7007 Anisomycin Protein synthesis inhibitor Anisomycin
  99. BCC7200 U0124 U0124
  100. BCC7236 SKF 86002 dihydrochloride SKF 86002 dihydrochloride
  101. BCC7274 CMPD-1 CMPD-1

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