A 68930 hydrochlorideAgonist of D1-like dopamine receptor,potent and selective CAS# 130465-39-3 |
- H 89 2HCl
Catalog No.:BCC4997
CAS No.:130964-39-5
- AT7867 dihydrochloride
Catalog No.:BCC1378
CAS No.:1431697-86-7
- 1-Azakenpaullone
Catalog No.:BCC5332
CAS No.:676596-65-9
- PHA-793887
Catalog No.:BCC2521
CAS No.:718630-59-2
- Dinaciclib (SCH727965)
Catalog No.:BCC3765
CAS No.:779353-01-4
- AT7867
Catalog No.:BCC2536
CAS No.:857531-00-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 130465-39-3 | SDF | Download SDF |
| PubChem ID | 9904672 | Appearance | Powder |
| Formula | C16H18ClNO3 | M.Wt | 307.78 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 50 mM in water | ||
| Chemical Name | (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol;hydrochloride | ||
| SMILES | C1C(OC(C2=C1C(=C(C=C2)O)O)CN)C3=CC=CC=C3.Cl | ||
| Standard InChIKey | PQPGUUQPTSMLKU-YYLIZZNMSA-N | ||
| Standard InChI | InChI=1S/C16H17NO3.ClH/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10;/h1-7,14-15,18-19H,8-9,17H2;1H/t14-,15-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo. |
A 68930 hydrochloride Dilution Calculator
A 68930 hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2491 mL | 16.2454 mL | 32.4907 mL | 64.9815 mL | 81.2269 mL |
| 5 mM | 0.6498 mL | 3.2491 mL | 6.4981 mL | 12.9963 mL | 16.2454 mL |
| 10 mM | 0.3249 mL | 1.6245 mL | 3.2491 mL | 6.4981 mL | 8.1227 mL |
| 50 mM | 0.065 mL | 0.3249 mL | 0.6498 mL | 1.2996 mL | 1.6245 mL |
| 100 mM | 0.0325 mL | 0.1625 mL | 0.3249 mL | 0.6498 mL | 0.8123 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
A 68930 hydrochloride is a potent and selective agonist of D1 dopamine receptor with EC50 values of 2.5 and 3920 nM for D1 and D2 receptors, respectively [1].
D1 dopamine receptor is a G-protein couple receptor for dopamine and stimulates adenylate cyclase and cyclic AMP-dependent protein kinases. D1 dopamine receptor plays an important role in behavioral responses and neuronal growth and development.
A 68930 hydrochloride is a potent and selective D1 dopamine receptor agonist. In rats, A 68930 (0.9-15.0 μM) induced hypothermia in a dose-dependent way. Also, A 68930 (0.9-15.0 μM) inhibited locomotor activity in a dose-dependent way [2]. In adult rat, A 68930 (0.0625-4.0 mg/kg) induced grooming, vacuous chewing and sniffing, which were inhibited by SCH 23390, a D1-like receptor antagonist [3]. In chronic unpredictable (CUS) stress rat models, A68930 (0.25 mg/kg) significantly normalized the reduction of the number of tyrosine hydroxylase (TH) immunoreactive neurons in the striatum, ventral tegmental area, medial forebrain bundle and substansia nigra and glucocorticoid receptor (GR) in the cortex, hippocampus and striatum. Also, A68930 normalized the antioxidant enzyme activities, increased glutathione (GSH) and inhibited lipid peroxidation [4].
References:
[1]. Kebabian JW, Briggs C, Britton DR, et al. A68930: a potent and specific agonist for the D-1 dopamine receptor. Am J Hypertens, 1990, 3(6 Pt 2): 40S-42S.
[2]. Salmi P. Independent roles of dopamine D1 and D2/3 receptors in rat thermoregulation. Brain Res, 1998, 781(1-2): 188-193.
[3]. Deveney AM, Waddington JL. Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists. Pharmacol Biochem Behav, 1997, 58(2): 551-558.
[4]. Rasheed N, Ahmad A, Al-Sheeha M, et al. Neuroprotective and anti-stress effect of A68930 in acute and chronic unpredictable stress model in rats. Neurosci Lett, 2011, 504(2): 151-155.
- Batimastat sodium salt
Catalog No.:BCC2075
CAS No.:130464-84-5
- Peucedanocoumarin III
Catalog No.:BCN3471
CAS No.:130464-57-2
- Peucedanocoumarin II
Catalog No.:BCN3435
CAS No.:130464-56-1
- Peucedanocoumarin I
Catalog No.:BCN3434
CAS No.:130464-55-0
- A-71623
Catalog No.:BCC7354
CAS No.:130408-77-4
- (-)-Catechin gallate(CG)
Catalog No.:BCN5330
CAS No.:130405-40-2
- Paulownin
Catalog No.:BCN6160
CAS No.:13040-46-5
- (RS)-MCPG disodium salt
Catalog No.:BCC7756
CAS No.:1303994-09-3
- CHPG Sodium salt
Catalog No.:BCC7755
CAS No.:1303993-73-8
- DL-AP5 Sodium salt
Catalog No.:BCC7753
CAS No.:1303993-72-7
- 2-Oxokolavenol
Catalog No.:BCN4716
CAS No.:130395-82-3
- Pungiolide A
Catalog No.:BCN8128
CAS No.:130395-54-9
- ent-11alpha-Hydroxyabieta-8(14),13(15)-dien-16,12alpha-olide
Catalog No.:BCN7330
CAS No.:130466-20-5
- L-655,708
Catalog No.:BCC7023
CAS No.:130477-52-0
- TC-F 2
Catalog No.:BCC6147
CAS No.:1304778-15-1
- SKF 96365 hydrochloride
Catalog No.:BCC6953
CAS No.:130495-35-1
- Cannabisin A
Catalog No.:BCC8138
CAS No.:130508-46-2
- Liriope muscari baily Saponins
Catalog No.:BCN2817
CAS No.:130551-41-6
- Mogroside III
Catalog No.:BCN3167
CAS No.:130567-83-8
- alpha-Terthienylmethanol
Catalog No.:BCN6161
CAS No.:13059-93-3
- Yangambin
Catalog No.:BCN6706
CAS No.:13060-14-5
- Nitidine chloride
Catalog No.:BCN4957
CAS No.:13063-04-2
- (R)-(+)-Corypalmine
Catalog No.:BCN2289
CAS No.:13063-54-2
- N-(2-Hydroxyethyl)-3-(4-nitrophenyl)propylamine
Catalog No.:BCC9053
CAS No.:130634-09-2
Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists.[Pubmed:9300618]
Pharmacol Biochem Behav. 1997 Oct;58(2):551-8.
The search for full-efficacy agonists selective for the "D1-like" family of dopamine receptor subtypes has recently generated two novel series of compounds: the isochromans, typified by A 68930, and the phenanthridines, typified by dihydrexidine. This study was undertaken to compare systematically the effects of these two agents on the spectrum of unconditioned motor behaviour (i.e., construction of their drug ethograms) in the intact adult rat and to determine the sensitivity of these responses to selective antagonists of "D1-like" (SCH 23390) vs. "D2-like" (YM 09151-2) receptors. A 68930 (0.0625-4.0 mg/kg) readily induced grooming, including intense grooming, the most widely accepted behavioural model of "D1-like" receptor stimulation; it also induced vacuous chewing, a more controversial model thereof, and sniffing. Conversely, dihydrexidine (0.25-16.0 mg/kg) induced grooming, but little intense grooming was evident; it failed to induce vacuous chewing but did induce sniffing. Grooming and sniffing responses to A 68930 were readily blocked by SCH 23390 (0.01-1.0 mg/kg) but were only attenuated or spared by YM 09151-2 (0.005-0.5 mg/kg). Conversely, the grooming and sniffing responses to dihydrexidine were readily blocked both by SCH 23390 and by YM 09151-2. A 68930 and dihydrexidine do not show identical psychopharmacological profiles; they appear to differ in the specificity of their effects on "D1-like" vs. "D2-like" function and may interact differentially with putative subtypes of "D1-like" receptors that are indicated behaviourally.
A68930: a potent and specific agonist for the D-1 dopamine receptor.[Pubmed:2143387]
Am J Hypertens. 1990 Jun;3(6 Pt 2):40S-42S.
A68930 (5,6-dihydroxy-3-phenyl-1-aminomethyl-isochroman) is a potent (EC50 = 2.5 nmol/L) partial agonist at the D-1 dopamine receptor. In contrast, A68930 is a much weaker agonist (EC50 = 3,920 nmol/L) at the D-2 dopamine receptor. The orientation of the 3-phenyl substituent in the molecule is critical for the affinity and selectivity of the molecule towards the D-1 receptor in vitro and in vivo. The role of the D-1 receptor in the functioning of the basal ganglia is discussed.
