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PI3K/Akt/mTOR Signaling

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. There are many known factors that enhance the PI3K/AKT pathway including EGF, shh, IGF-1, insulin, and CaM. The pathway is antagonized by various factors including PTEN, GSK3B, and HB9. In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation. This pathway is necessary, however, to promote growth and proliferation over differentiation of adult stem cells, neural stem cells specifically. It is the difficulty in finding an appropriate amount of proliferation versus differentiation that researchers are trying to determine in order to utilize this balance in the development of various therapies. Additionally, this pathway has been found to be a necessary component in neural long term potentiation.

Products for PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. BCN2385 Indirubin Indirubin
  3. BCN5415 Isobavachalcone Isobavachalcone
  4. BCC1059 WYE-354 MTOR inhibitor,potent,ATP-competitive and cell-permeable WYE-354
  5. BCC1073 AZD5363 AKT inhibitor,pyrrolopyrimidine derived AZD5363
  6. BCC1094 GDC-0349 MTOR inhibitor GDC-0349
  7. BCC1104 IPI-145 (INK1197) PI3K-δ/PI3K-γ inhibitor IPI-145 (INK1197)
  8. BCC1110 KU-0060648 Dual DNA-PK and PI 3-K inhibitor KU-0060648
  9. BCC1161 IC-87114 PI3Kδ inhibitor IC-87114
  10. BCC1162 PI-103 Class I PI3K, mTOR and DNA-PK inhibitor PI-103
  11. BCC1163 PIK-75 Inhibitor of PI3K isoform p110α PIK-75
  12. BCC1244 TGX-221 PI3Kβ inhibitor,potent,selective and ATP competitive TGX-221
  13. BCC1247 TG100-115 PI3Kγ/PI3Kδ inhibitor TG100-115
  14. BCC1248 PIK-90 PI3K inhibitor,potent selective PIK-90
  15. BCC1250 BX-912 PDK1 inhibitor,potent and ATP-competitive BX-912
  16. BCC1255 OSU-03012 (AR-12) PDPK1 (PDK1) inhibitor; inhibits Akt signaling OSU-03012 (AR-12)
  17. BCC1270 CAL-101 (Idelalisib, GS-1101) PI3K inhibitor CAL-101 (Idelalisib, GS-1101)
  18. BCC1271 GDC-0068 (RG7440) Pan-AKT inhibitor,highly selective GDC-0068 (RG7440)
  19. BCC1274 MK-2206 dihydrochloride Akt1/2/3 inhibitor MK-2206 dihydrochloride
  20. BCC1275 CHIR-99021 (CT99021) Highly selective GSK-3 inhibitor CHIR-99021 (CT99021)
  21. BCC1279 BKM120 Inhibitor of pan-Class I PI3K BKM120
  22. BCC1310 PI4KIII beta inhibitor 3 PI4KIII beta inhibitor PI4KIII beta inhibitor 3
  23. BCC1321 A-443654 Akt inhibitor,potent and selective A-443654
  24. BCC1334 AKT inhibitor VIII Potent and selective dual Akt1 and 2 inhibitor AKT inhibitor VIII
  25. BCC1335 AKT Kinase Inhibitor AKT Kinase Inhibitor
  26. BCC1378 AT7867 dihydrochloride Akt1 and p70S6K/PKA inhibitor AT7867 dihydrochloride
  27. BCC1416 BEZ235 Tosylate MTOR/P13K inhibitor BEZ235 Tosylate
  28. BCC1440 CAL-130 PI3K inhibitor CAL-130
  29. BCC1441 CAL-130 Hydrochloride PI3K inhibitor CAL-130 Hydrochloride
  30. BCC1442 CAL-130 Racemate PI3K inhibitor CAL-130 Racemate
  31. BCC1489 CMK RSK2 kinase inhibitor CMK
  32. BCC1507 CZC24832 Selective PI3K-γ inhibitor CZC24832
  33. BCC1518 Daun02 Cell viability inhibitor,DNA synthisis inhibitor Daun02
  34. BCC1533 DMAT CK2 inhibitor,potent and selective DMAT
  35. BCC1580 FMK RSK inhibitor FMK
  36. BCC1590 GDC-0941 dimethanesulfonate PI3K inhibitor GDC-0941 dimethanesulfonate
  37. BCC1715 LY 303511 MTOR inhibitor LY 303511
  38. BCC1717 LY2090314 Potent GSK-3 inhibitor LY2090314
  39. BCC1781 GDC-mTOR inhibitor MTOR inhibitor GDC-mTOR inhibitor
  40. BCC1805 Nordihydroguaiaretic acid Anti-tumor agent;lipoxygenase inhibitor Nordihydroguaiaretic acid
  41. BCC1813 NVP-BAG956 Dual PI 3-kinase and PDPK1 (PDK1) inhibitor NVP-BAG956
  42. BCC1843 PDK1 inhibitor PDK1 inhibitor PDK1 inhibitor
  43. BCC1860 PI-103 Hydrochloride Inhibitor of PI 3-kinase, mTOR and DNA-PK PI-103 Hydrochloride
  44. BCC1861 PI3k-delta inhibitor 1 PI3k-delta inhibitor PI3k-delta inhibitor 1
  45. BCC1876 QL-IX-55 TORC1/TORC2 inhibitor QL-IX-55
  46. BCC1988 TBB Selective cell-permeable CK2 inhibitor TBB
  47. BCC2017 TTP 22 High affinity, selective CK2 inhibitor TTP 22
  48. BCC2047 VS-5584 (SB2343) MTOR/P13K inhibitor,potent and selective VS-5584 (SB2343)
  49. BCC2059 XL388 Potent and selective mTOR inhibitor; antitumor XL388
  50. BCC2060 XL765 PI3K/mTOR inhibitor XL765
  51. BCC2483 GSK690693 Akt kinase inhibitor. Antitumor GSK690693
  52. BCC2484 KU-0063794 Selective mTOR inhibitor KU-0063794
  53. BCC2487 XL147 PI3K inhibitor,selective and reversible XL147
  54. BCC2495 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240
  55. BCC2519 PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor PIK-93
  56. BCC2523 AZD6482 PI3Kβ inhibitor,potent and selective AZD6482
  57. BCC2534 SAR245409 (XL765) mTOR/PI3K inhibitor SAR245409 (XL765)
  58. BCC2536 AT7867 Akt1/2/3 and p70S6K/PKA inhibitor AT7867
  59. BCC2554 PHT-427 Dual Akt and PDPK1 (PDK1) inhibitor; antitumor PHT-427
  60. BCC3592 Rapamycin (Sirolimus) mTOR inhibitor; also drives hPSC differentiation to mesendoderm and blood progenitor cells Rapamycin (Sirolimus)
  61. BCC3594 Everolimus (RAD001) MTOR inhibitor Everolimus (RAD001)
  62. BCC3606 AICAR AMPK activator; promotes osteogenic differentiation of bone marrow-derived MSCs AICAR
  63. BCC3626 GDC-0941 PI3K inhibitor,potent and selective GDC-0941
  64. BCC3629 AZD8055 MTOR inhibitor AZD8055
  65. BCC3635 BX795 PDPK1 (PDK1) inhibitor BX795
  66. BCC3650 SB 216763 Potent, selective GSK-3 inhibitor SB 216763
  67. BCC3651 SB 415286 Potent, selective GSK-3 inhibitor SB 415286
  68. BCC3655 BEZ235 (NVP-BEZ235) PI3K/mTOR inhibitor,ATP-competitve BEZ235 (NVP-BEZ235)
  69. BCC3657 ZSTK474 Potent PI3K inhibitor ZSTK474
  70. BCC3659 LY 294002 Potent PI3K inhibitor LY 294002
  71. BCC3673 Perifosine Akt inhibitor Perifosine
  72. BCC3676 Torin 1 Potent and selective mTOR inhibitor; induces autophagy in HeLa cells Torin 1
  73. BCC3678 Temsirolimus mTOR inhibitor; arrests cell cycle at G1/S Temsirolimus
  74. BCC3679 NU7441 (KU-57788) Potent and selective DNA-PK inhibitor NU7441 (KU-57788)
  75. BCC3682 PP242 Dual mTORC1/mTORC2 inhibitor PP242
  76. BCC3707 BYL-719 Selective PI3Kα inhibitor BYL-719
  77. BCC3715 A66 P110α inhibitor A66
  78. BCC3732 AZD2014 Novel mTOR inhibitor AZD2014
  79. BCC3751 CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive CHIR-98014
  80. BCC3827 NVP-BGT226 PI3K/mTOR inhibitor,selective and novel NVP-BGT226
  81. BCC3837 PF-04691502 Potent and selective dual PI 3-K/mTOR inhibitor PF-04691502
  82. BCC3843 PKI-402 PI3K inhibitor,selective, reversible and ATP-competitive PKI-402
  83. BCC3872 Triciribine Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral Triciribine
  84. BCC3880 INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective INK 128 (MLN0128)
  85. BCC3884 GSK2126458 PI3K/mTOR inhibitor GSK2126458
  86. BCC3903 A-674563 Akt1/PKA/CDK2 inhibitor,potent and selective A-674563
  87. BCC3904 CCT128930 AKT inhibitor CCT128930
  88. BCC3905 Palomid 529 PI3K/Akt/mTOR inhibitor Palomid 529
  89. BCC3906 TIC10 Potent Akt/ERK inhibitor TIC10
  90. BCC3913 ETP-46464 ATR inhibitor,potent and selective ETP-46464
  91. BCC3933 NU 7026 Selective DNA-PK inhibitor NU 7026
  92. BCC4010 HTH-01-015 Potent and selective NUAK1 inhibitor HTH-01-015
  93. BCC4066 GDC-0032 PI3Kα inhibitor GDC-0032
  94. BCC4085 Imeglimin hydrochloride Antidiabetic agent Imeglimin hydrochloride
  95. BCC4086 YLF-466D YLF-466D
  96. BCC4126 GSK-3 inhibitor 1 GSK-3 inhibitor 1
  97. BCC4180 PI3Kγ inhibitor 1 PI3Kγ inhibitor 1
  98. BCC4181 NVP-QAV-572 NVP-QAV-572
  99. BCC4220 AICAR phosphate AMPK activator AICAR phosphate
  100. BCC4221 Imeglimin Antidiabetic agent Imeglimin
  101. BCC4258 TDZD-8 GSK-3β inhibitor TDZD-8

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