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Tyrosine Kinase/Adaptors

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase. The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division. Protein kinases can become mutated, stuck in the "on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. Therefore, kinase inhibitors, such as imatinib, are often effective cancer treatments.

Products for Tyrosine Kinase/Adaptors

  1. Cat.No. Product Name Information
  2. BCN5539 Damnacanthal Potent, selective p56lck inhibitor; also LIMK1/2 inhibitor Damnacanthal
  3. BCN1808 Lavendustin A EGFR, p60c-src inhibitor Lavendustin A
  4. BCN2174 Sorafenib Sorafenib
  5. BCC1053 BMS-754807 IGF-1R/InsR inhibitor,potent and selective BMS-754807
  6. BCC1054 AMG-208 C-Met inhibitor,potent and highly selective AMG-208
  7. BCC1055 SGX-523 Selective and potent c-MET kinase inhibitor SGX-523
  8. BCC1062 GSK1904529A Selective IGF-1R/IR inhibitor GSK1904529A
  9. BCC1096 GW2580 Selective cFMS kinase inhibitor; orally bioavailable GW2580
  10. BCC1111 Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor Vatalanib (PTK787) 2HCl
  11. BCC1116 Ki8751 Potent, selective VEGFR-2 inhibitor Ki8751
  12. BCC1121 Cediranib (AZD217) VEGFR inhibitor receptor,highly potent Cediranib (AZD217)
  13. BCC1159 PQ 401 IGF1R inhibitor PQ 401
  14. BCC1169 Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor Dovitinib (TKI-258, CHIR-258)
  15. BCC1172 Lenvatinib (E7080) VEGFR inhibitor Lenvatinib (E7080)
  16. BCC1177 BMS-536924 Dual IR/IGF1R inhibitor BMS-536924
  17. BCC1179 Tivozanib (AV-951) VEGFR inhibitor,potent and selective Tivozanib (AV-951)
  18. BCC1180 NVP-AEW541 IGF-IR inhibitor, novel, potent and selective NVP-AEW541
  19. BCC1181 PHA-665752 Potent and selective MET inhibitor PHA-665752
  20. BCC1183 TCS 359 Potent FLT3 inhibitor TCS 359
  21. BCC1195 Tyrphostin AG 1296 PDGFR inhibitor,selective and ATP-competitive Tyrphostin AG 1296
  22. BCC1231 Brivanib (BMS-540215) VEGFR-2 inhibitor,ATP-competitive Brivanib (BMS-540215)
  23. BCC1240 Brivanib Alaninate (BMS-582664) VEGFR2 inhibitor,ATP-competitive Brivanib Alaninate (BMS-582664)
  24. BCC1242 AG-1024 Selective IGF-1R inhibitor AG-1024
  25. BCC1243 SU11274 Selective inhibitor of MET kinase activity SU11274
  26. BCC1253 OSI-930 Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck OSI-930
  27. BCC1260 Masitinib (AB1010) Tyrosine kinase inhibitor, potent and selective Masitinib (AB1010)
  28. BCC1261 Linifanib (ABT-869) VEGFR/PDGFR inhibitor Linifanib (ABT-869)
  29. BCC1263 Foretinib (GSK1363089) VEGF and HGF receptor inhibitor Foretinib (GSK1363089)
  30. BCC1264 Cabozantinib (XL184, BMS-907351) Potent VEGFR inhibitor; also inhibits other RTKs Cabozantinib (XL184, BMS-907351)
  31. BCC1278 BGJ398 FGFR inhibitor ,potent and selective BGJ398
  32. BCC1284 (R)-Crizotinib Potent c-MET/ALK inhibitor (R)-Crizotinib
  33. BCC1286 Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor Pazopanib (GW-786034)
  34. BCC1323 A-770041 Selective Lck inhibitor A-770041
  35. BCC1330 Afatinib dimaleate Afatinib dimaleate
  36. BCC1333 AIM-100 Potent and selective Ack1 inhibitor AIM-100
  37. BCC1339 ALK inhibitor 1 ALK inhibitor, novel and selective ALK inhibitor 1
  38. BCC1340 ALK inhibitor 2 ALK inhibitor, novel and selective ALK inhibitor 2
  39. BCC1350 ALW-II-41-27 Eph receptor inhibitor ALW-II-41-27
  40. BCC1372 ASP3026 Potent Ack (TNK2) inhibitor; also inhibits anaplastic lymphoma kinase (ALK) ASP3026
  41. BCC1373 AST 487 RET kinase inhibitor AST 487
  42. BCC1386 AVL-292 benzenesulfonate Selective Btk inhibitor AVL-292 benzenesulfonate
  43. BCC1388 AXL1717 Selective IGF1R inhibitor AXL1717
  44. BCC1406 BAY 61-3606 Syk Inhibitor BAY 61-3606
  45. BCC1407 BAY 61-3606 dihydrochloride Syk tyrosine kinase inhibitor BAY 61-3606 dihydrochloride
  46. BCC1418 BIBX 1382 EGFR inhibitor,potent and selective BIBX 1382
  47. BCC1424 BMS-509744 Potent and selective ITK inhibitor BMS-509744
  48. BCC1426 BMS-599626 Hydrochloride EGFR/HER2 inhibitor,potent and selective BMS-599626 Hydrochloride
  49. BCC1434 BMX-IN-1 BMX (also termed ETK) kinase inhibitor BMX-IN-1
  50. BCC1449 Canertinib dihydrochloride Potent EGFR kinase inhibitor Canertinib dihydrochloride
  51. BCC1472 c-FMS inhibitor C-FMS kinase inhibitor c-FMS inhibitor
  52. BCC1488 c-Met inhibitor 1 Inhibitor of the c-Met receptor c-Met inhibitor 1
  53. BCC1517 Dasatinib hydrochloride Multi-BCR/Abl and Src kinase inhibitor, oral active Dasatinib hydrochloride
  54. BCC1520 DCC-2618 C-Kit/PDGFR inhibtor DCC-2618
  55. BCC1541 E-3810 VEGF/FGF dual inhibitor, potent and selective E-3810
  56. BCC1550 EMD-1214063 C-Met inhibitor,potent and selective EMD-1214063
  57. BCC1558 Erlotinib mesylate EGFR inhibitor Erlotinib mesylate
  58. BCC1572 Fenretinide Synthetic retinoid; antiproliferative and antioxidant Fenretinide
  59. BCC1644 Imatinib hydrochloride V-Abl/c-Kit/PDGFR inhibitor Imatinib hydrochloride
  60. BCC1654 IRAK inhibitor 1 IRAK-4 inhibitor IRAK inhibitor 1
  61. BCC1655 IRAK inhibitor 2 IRAK inhibitor 2
  62. BCC1656 IRAK inhibitor 3 IRAK inhibitor 3
  63. BCC1657 IRAK inhibitor 4 IRAK inhibitor IRAK inhibitor 4
  64. BCC1658 IRAK inhibitor 6 IRAK-4 inhibitor IRAK inhibitor 6
  65. BCC1659 IRAK-1-4 Inhibitor I IRAK4 and IRAK1 inhibitor IRAK-1-4 Inhibitor I
  66. BCC1662 ITK inhibitor Potent ITK inhibitor ITK inhibitor
  67. BCC1666 Ixabepilone Epothilone B analog;microtubule-stabilizing agent Ixabepilone
  68. BCC1678 Ki20227 c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation Ki20227
  69. BCC1685 KU14R I(3)-R antagonist KU14R
  70. BCC1686 KX2-391 dihydrochloride Src kinase inhibitor KX2-391 dihydrochloride
  71. BCC1689 Lck Inhibitor Potent Lck inhibitor Lck Inhibitor
  72. BCC1690 Lck inhibitor 2 Tyrosine kinases inhibitor Lck inhibitor 2
  73. BCC1694 LDK378 dihydrochloride ALK inhibitor LDK378 dihydrochloride
  74. BCC1706 LRRK2-IN-1 Potent and selective LRRK2 inhibitor LRRK2-IN-1
  75. BCC1720 LY2801653 MET inhibitor LY2801653
  76. BCC1721 LY2801653 dihydrochloride MET inhibitor LY2801653 dihydrochloride
  77. BCC1723 LY2874455 FGF/FGFR Inhibitor LY2874455
  78. BCC1729 Masitinib mesylate Tyrosine kinase inhibitor Masitinib mesylate
  79. BCC1768 MK-8033 C-MET inhibitor MK-8033
  80. BCC1776 Motesanib Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit Motesanib
  81. BCC1792 N-Desethyl Sunitinib VEGFR/PDGFR?/KIT inhibitor N-Desethyl Sunitinib
  82. BCC1814 NVP-BGJ398 phosphate FGFR inhibitor NVP-BGJ398 phosphate
  83. BCC1849 PF-04217903 methanesulfonate Highly selective MET inhibitor PF-04217903 methanesulfonate
  84. BCC1866 PND-1186 Potent FAK inhibitor PND-1186
  85. BCC1869 PRT062607 Hydrochloride SYK inhibitor,potent and selective PRT062607 Hydrochloride
  86. BCC1883 Regorafenib hydrochloride Regorafenib hydrochloride
  87. BCC1884 Regorafenib monohydrate Tyrosine kinase inhibitor Regorafenib monohydrate
  88. BCC1948 Silvestrol Antineoplastic Silvestrol
  89. BCC1963 SR1078 Orphan receptor agonist SR1078
  90. BCC1964 SR3335 ROR? agonist,partial inverse and selective SR3335
  91. BCC1970 SU 5402 Potent VEGFR and FGFR inhibitor SU 5402
  92. BCC1971 SU14813 Tyrosine kinase inhibitor SU14813
  93. BCC1972 SU14813 double bond Z Tyrosine kinase inhibitor SU14813 double bond Z
  94. BCC1973 SU14813 maleate VEGFR/PDGFR/Kit/FLT-3 inhibitor SU14813 maleate
  95. BCC1974 SU5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 SU5416
  96. BCC1994 TG 100572 TG 100572
  97. BCC1995 TG 100572 Hydrochloride TG 100572 Hydrochloride
  98. BCC1996 TG 100801 Multi-kinase inhibitor TG 100801
  99. BCC1997 TG 100801 Hydrochloride VEGFr2 inhibitor TG 100801 Hydrochloride
  100. BCC2005 Toceranib Potent PDGFR and VEGFR inhibitor; induces cell cycle arrest Toceranib
  101. BCC2006 Toceranib phosphate c-Kit/VEGFR/PDGFR inhibtor Toceranib phosphate

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