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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC1403 Bavisant dihydrochloride Bavisant Hcl (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
BCC5038 Desvenlafaxine Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
BCC1586 gamma-Secretase Modulators gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease.
BCC4534 Roxatidine Acetate HCl Roxatidine Acetate Hydrochloride is a specific and competitive histamin H2 receptor antagonist.
BCC1589 GAP-134 Hydrochloride Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
BCC1588 GAP-134 Danegaptide (GAP-134), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
BCC1712 LX-1031 LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
BCC6156 MNI 137
BCC6118 3-pyr-Cytisine
BCC7651 Desformylflustrabromine hydrochloride Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
BCC1245 10Panx Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
BCC1759 MK-3207 MK-3207 is a potent and orally bioavailable CGRP receptor antagonist (IC50= 0.12 nM; Ki value= 0.024 nM); highly selective versus human AM1, AM2, CTR, and AMY3.
BCC7201 Ipsapirone
BCC1213 Vortioxetine (Lu AA21004) HBr Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
BCC6885 Chlorisondamine diiodide
BCC7267 (±)-McN 5652 Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
BCC7123 Indatraline hydrochloride
BCC5161 Cyproheptadine hydrochloride Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.
BCC7344 AMN 082 dihydrochloride The first selective mGlu₇ agonist
BCC7100 Quinelorane hydrochloride
BCC7193 Eticlopride hydrochloride
BCC4541 Latrepirdine Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
BCC4515 Brompheniramine hydrogen maleate Brompheniramine maleate is a histamine H1 receptors antagonist.
BCC1020 Myelin Basic Protein (68-82), guinea pig Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).
BCC6655 Nitrocaramiphen hydrochloride
BCC6754 Anpirtoline hydrochloride
BCC4520 Levodropropizine Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
BCC2513 Venlafaxine Hydrochloride Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
BCC4426 Ampiroxicam Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
BCC2493 Ondansetron HCl Selective 5-HT₃ antagonist,Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
BCC5043 Ondansetron Ondansetron(GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
BCC1907 Rotigotine Rotigotine (N-0437; N-0923) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.