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Chromatin/Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. BCN2169 5-Aza-2'-deoxycytidine DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine
  3. BCN2483 Ginkgolic acid C15:0 Noncompetitive PCAF/p300 inhibitor Ginkgolic acid C15:0
  4. BCN5607 Resveratrol Cyclooxygenase inhibitor Resveratrol
  5. BCC1129 3-Deazaneplanocin,DZNep Cell-permeable histone methyltransferase inhibitor 3-Deazaneplanocin,DZNep
  6. BCC1130 5-Azacytidine DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes 5-Azacytidine
  7. BCC1131 BIX 01294 G9a and GLP inhibitor BIX 01294
  8. BCC1132 Bromodomain Inhibitor, (+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable Bromodomain Inhibitor, (+)-JQ1
  9. BCC1133 Lomeguatrib MGMT inhibitor Lomeguatrib
  10. BCC1134 RG 108 Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation RG 108
  11. BCC1135 UNC0638 G9a/GLP HMTase inhibitor, potent and selective UNC0638
  12. BCC1136 Zebularine DNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs Zebularine
  13. BCC1267 ABT-888 (Veliparib) Potent PARP inhibitor ABT-888 (Veliparib)
  14. BCC1276 Ruxolitinib (INCB018424) JAK inhibitor Ruxolitinib (INCB018424)
  15. BCC1393 AZD1152 Aurora B kinase inhibitor,highly potent and selective AZD1152
  16. BCC1400 Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator Bardoxolone methyl
  17. BCC1401 Baricitinib phosphate JAK1/JAK2 inhibitor Baricitinib phosphate
  18. BCC1422 BMN-673 8R,9S PARP inhibitor BMN-673 8R,9S
  19. BCC1504 CX-6258 Pan-Pim kinases Inhibitor CX-6258
  20. BCC1505 CX-6258 hydrochloride hydrate Pan-Pim kinases Inhibitor CX-6258 hydrochloride hydrate
  21. BCC1506 CYT387 sulfate salt JAK1/JAK2 inhibitor CYT387 sulfate salt
  22. BCC1603 GSK 525768A inactive stereoisomer of I-BET-762 GSK 525768A
  23. BCC1667 JAK2 Inhibitor V, Z3 Jak2 tyrosine kinase inhibitor JAK2 Inhibitor V, Z3
  24. BCC1668 JANEX-1 JAK3 inhibitor JANEX-1
  25. BCC1705 LKB1 (AAK1 dual inhibitor) Pim-1 kinase inhibitor LKB1 (AAK1 dual inhibitor)
  26. BCC1761 MK-4827 PARP-1/-2 inhibitor,potent and selective MK-4827
  27. BCC1815 NVP-BSK805 ATP-competitive JAK2 inhibitor NVP-BSK805
  28. BCC1829 OTX-015 BRD inhibitor OTX-015
  29. BCC1865 PJ34 PARP-l inhibitor PJ34
  30. BCC1874 Pyridone 6 Pan-JAK inhibitor Pyridone 6
  31. BCC1892 Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor Reversine
  32. BCC1912 Ruxolitinib phosphate JAK1/JAK2 inhibitor Ruxolitinib phosphate
  33. BCC1913 Ruxolitinib sulfate JAK inhibitor Ruxolitinib sulfate
  34. BCC1925 SB1317 CDK,JAK and FLT inhibitor SB1317
  35. BCC1934 SCH-1473759 Aurora A/B inhibitor SCH-1473759
  36. BCC1950 SRT2104 (GSK2245840) SRT2104 (GSK2245840)
  37. BCC2023 UNC1215 Chemical probe for the methyllysine (Kme) UNC1215
  38. BCC2056 WHI-P97 Janus kinase (JAK)-3 inhibitor WHI-P97
  39. BCC2057 XL019 JAK2 inhibitor,potent and selective XL019
  40. BCC2058 XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor XL228
  41. BCC2076 Veliparib dihydrochloride PARP-1/PARP-2 inhibitor Veliparib dihydrochloride
  42. BCC2079 AZD1208 PIM kinase inhibitor AZD1208
  43. BCC2166 MLN8237 (Alisertib) Aurora A Kinase inhibitor, Potent and selective MLN8237 (Alisertib)
  44. BCC2167 VX-680 (MK-0457,Tozasertib) High affinity and selective Aurora kinase inhibitor VX-680 (MK-0457,Tozasertib)
  45. BCC2168 Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective Barasertib (AZD1152-HQPA)
  46. BCC2169 ZM 447439 Inhibits Aurora kinase B ZM 447439
  47. BCC2170 MLN8054 Aurora A inhibitor MLN8054
  48. BCC2171 JNJ-7706621 Potent CDK/Aurora kinase inhibitor JNJ-7706621
  49. BCC2173 AT9283 Aurora kinase/JAK inhibitor AT9283
  50. BCC2174 Hesperadin Potent Aurora kinase B inhibitor Hesperadin
  51. BCC2175 AMG-900 Aurora kinase inhibitor AMG-900
  52. BCC2176 MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective MK-5108 (VX-689)
  53. BCC2177 SNS-314 Mesylate Potent pan-Aurora kinase inhibitor SNS-314 Mesylate
  54. BCC2178 PHA-680632 Aurora kinase inhibitor,novel and potent PHA-680632
  55. BCC2180 TAK-901 Novel Aurora A/B inhibitor TAK-901
  56. BCC2181 CYC116 Potent Aurora A/B inhibitor CYC116
  57. BCC2183 GSK1070916 Aurora B/C inhibitor GSK1070916
  58. BCC2184 PF-03814735 Aurora kinase A and B inhibitor PF-03814735
  59. BCC2185 ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor ENMD-2076 L-(+)-Tartaric acid
  60. BCC2186 ENMD-2076 Selective Aurora A/Flt3 inhibitor ENMD-2076
  61. BCC2187 CCT129202 Aurora kinase inhibitor,ATP-competitive and potent CCT129202
  62. BCC2188 CCT137690 Potent pan-Aurora kinase inhibitor CCT137690
  63. BCC2189 Tofacitinib (CP-690550) Citrate Potent JAK inhibitor Tofacitinib (CP-690550) Citrate
  64. BCC2190 TG101348 (SAR302503) JAK-2 inhibitor,potent and selective TG101348 (SAR302503)
  65. BCC2191 AZD1480 Potent and selective JAK2 inhibitor; antiangiogenic AZD1480
  66. BCC2192 Tofacitinib (CP-690550,Tasocitinib) Janus kinase inhibitor Tofacitinib (CP-690550,Tasocitinib)
  67. BCC2195 Baricitinib (LY3009104, INCB028050) JAK1/JAK2 inhibitor,selective orally bioavailable Baricitinib (LY3009104, INCB028050)
  68. BCC2196 CYT387 JAK-1/-2 inhibitor,ATP competitive CYT387
  69. BCC2197 AZ 960 JAKs inhibitor AZ 960
  70. BCC2199 CEP-33779 JAK2 inhibitor,highly selective CEP-33779
  71. BCC2200 LY2784544 JAK2 inhibitor,highly potent and selective LY2784544
  72. BCC2201 S-Ruxolitinib (INCB018424) JAK1/2 inhibitor,potent and selective S-Ruxolitinib (INCB018424)
  73. BCC2206 Olaparib (AZD2281, Ku-0059436) Potent PARP1/PARP2 inhibitor Olaparib (AZD2281, Ku-0059436)
  74. BCC2207 Rucaparib (AG-014699,PF-01367338) Potent PARP inhibitor Rucaparib (AG-014699,PF-01367338)
  75. BCC2208 Iniparib (BSI-201) PARP-1 inhibitor Iniparib (BSI-201)
  76. BCC2210 PJ34 hydrochloride Potent PARP inhibitor PJ34 hydrochloride
  77. BCC2211 A-966492 PARP-1/-2 inhibitor, highly potent A-966492
  78. BCC2212 INO-1001 PARP inhibitor INO-1001
  79. BCC2213 UPF 1069 PARP-2 inhibitor UPF 1069
  80. BCC2214 AZD2461 Novel PARP inhibitor AZD2461
  81. BCC2215 EPZ5676 DOT1L inhibitor,potent and SAM competitive EPZ5676
  82. BCC2216 SGC 0946 DOT1L inhibitor,highly potent and selective SGC 0946
  83. BCC2217 Entacapone COMT inhibitor Entacapone
  84. BCC2218 EPZ004777 Highly potent DOT1L inhibitor EPZ004777
  85. BCC2219 EPZ005687 EZH2 inhibitor,potent and selective EPZ005687
  86. BCC2221 SGI-110 DNA methyltransferases inhibitor,potent SGI-110
  87. BCC2222 SRT1720 HCl SIRT1 activator SRT1720 HCl
  88. BCC2223 EX 527 (SEN0014196) Selective SIRT1 inhibitor EX 527 (SEN0014196)
  89. BCC2224 Sirtinol Selective sirtuin family deacetylase inhibitor Sirtinol
  90. BCC2225 PFI-1 (PF-6405761) BET bromodomain inhibitor PFI-1 (PF-6405761)
  91. BCC2226 Bromosporine Bromodomain inhibitor,non-selective Bromosporine
  92. BCC2230 GSK J4 HCl Histone KDM inhibitor; cell permeable GSK J4 HCl
  93. BCC2231 GSK J1 Potent JMJD3/UTX inhibitor GSK J1
  94. BCC2232 SGI-1776 free base Pim kinase inhibitor,ATP-competitive SGI-1776 free base
  95. BCC2418 TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor TC-A 2317 hydrochloride
  96. BCC2419 SGC-CBP30 Inhibitor of CREBBP/EP300 bromodomain,potent SGC-CBP30
  97. BCC2429 Chaetocin SUV39H1 Inhibitor Chaetocin
  98. BCC2430 UNC 0224 Potent G9a and GLP inhibitor UNC 0224
  99. BCC2431 UNC 0646 Potent and selective G9a and GLP inhibitor UNC 0646
  100. BCC2432 Chetomin A4505 inhibitor Chetomin
  101. BCC2433 DMOG Prolyl hydroxylase inhibitor DMOG

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