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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

  1. Cat.No. Product Name Information
  2. BCC1324 A-867744 A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM. A-867744
  3. BCC7384 VUF 8430 dihydrobromide VUF 8430 dihydrobromide
  4. BCC4532 Pemirolast potassium Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. Pemirolast potassium
  5. BCC4540 Desloratadine Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies. Desloratadine
  6. BCN5983 Rotundine Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. Rotundine
  7. BCC1542 Ebrotidine Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection. Ebrotidine
  8. BCC6991 CY 208-243 CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity. CY 208-243
  9. BCC4579 Pyridostigmine Bromide Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Pyridostigmine Bromide
  10. BCN1946 Hyoscyamine L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. Hyoscyamine
  11. BCC4922 Milnacipran HCl Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Milnacipran HCl
  12. BCC5250 Talipexole Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent. Talipexole
  13. BCC1613 GW791343 dihydrochloride GW791343 dihydrochloride is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). GW791343 dihydrochloride
  14. BCC1881 rac-Rotigotine Hydrochloride (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. rac-Rotigotine Hydrochloride
  15. BCC7000 RJR 2429 dihydrochloride RJR 2429 dihydrochloride
  16. BCC8074 ARN2966 ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. ARN2966
  17. BCC6939 AF-DX 116 Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively. AF-DX 116
  18. BCN1057 (-)-Huperzine A (-)-Huperzine A (Huperzine A), an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). (-)-Huperzine A
  19. BCC6285 VUF 10460 VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. VUF 10460
  20. BCC6636 MDL 73005EF hydrochloride MDL 73005EF hydrochloride
  21. BCC5269 Acetaminophen Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. Acetaminophen
  22. BCC7616 Z-Cyclopentyl-AP4 Z-Cyclopentyl-AP4
  23. BCC5645 Sumatriptan Sumatriptan
  24. BCC2502 Sumatriptan Succinate Sumatriptan succinate (GR 43175) is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache. Sumatriptan Succinate
  25. BCC4213 Ondansetron hydrochloride dihydrate Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. Ondansetron hydrochloride dihydrate
  26. BCC4582 Trospium chloride Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride
  27. BCC6922 Zolantidine dimaleate Zolantidine dimaleate
  28. BCN2181 Pramipexole dihydrochloride Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. Pramipexole dihydrochloride
  29. BCC4467 Pramipexole Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole
  30. BCC1528 Dexpramipexole dihydrochloride Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist. Dexpramipexole dihydrochloride
  31. BCC1527 Dexpramipexole Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value: Dexpramipexole
  32. BCC7963 A 331440 dihydrochloride Selective H3 antagonist A 331440 dihydrochloride
  33. BCC4132 Mizolastine dihydrochloride Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Mizolastine dihydrochloride
  34. BCC4027 Tropisetron Hydrochloride Tropisetron Hydrochloride (SDZ-ICS-930) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. Tropisetron Hydrochloride
  35. BCC6734 Thioperamide Thioperamide
  36. BCC3850 Risperidone Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Risperidone
  37. BCC1060 Granisetron HCl Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Granisetron HCl
  38. BCC1044 Amyloid Beta-Peptide (12-28) (human) β-amyloid (12-28) is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research. Amyloid Beta-Peptide (12-28) (human)
  39. BCC1470 Cevimeline Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB). Cevimeline
  40. BCC7116 Roxindole hydrochloride Roxindole hydrochloride
  41. BCC7121 SKF 83566 hydrobromide SKF 83566 hydrobromide
  42. BCC7732 A 987306 Potent and selective H4 receptor antagonist A 987306
  43. BCC1454 Cariprazine hydrochloride Cariprazine hydrochloride is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). Cariprazine hydrochloride
  44. BCC4521 Mizolastine Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. Mizolastine
  45. BCC6732 CGS 12066B dimaleate CGS 12066B dimaleate
  46. BCC5061 WAY 100635 hydrochloride WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM. WAY 100635 hydrochloride
  47. BCC7615 VU 0155041 VU 0155041
  48. BCC5516 JNJ-31020028 JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. JNJ-31020028
  49. BCC1601 Granisetron Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Granisetron
  50. BCC7264 α-Bungarotoxin α-Bungarotoxin
  51. BCC1404 Bavisant dihydrochloride hydrate Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. Bavisant dihydrochloride hydrate
  52. BCC6960 [Sar9,Met(O2)11]-Substance P [Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P
  53. BCC6585 2,4-Dihydroxyphenylacetyl-L-asparagine 2,4-Dihydroxyphenylacetyl-L-asparagine
  54. BCC6590 (1S,3R)-ACPD (1S,3R)-ACPD
  55. BCC1877 Quetiapine Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Quetiapine
  56. BCN5339 Quetiapine fumarate Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Quetiapine fumarate
  57. BCC6897 Methyllycaconitine citrate Methyllycaconitine citrate
  58. BCC4078 Mosapride Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. Mosapride
  59. BCC1065 Mosapride Citrate Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist. Mosapride Citrate
  60. BCC4469 PD128907 HCl PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. PD128907 HCl
  61. BCC3753 Chlorprothixene Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. Chlorprothixene
  62. BCC4526 Chlorpheniramine Maleate Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. Chlorpheniramine Maleate
  63. BCC7907 VU 0357017 hydrochloride VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). VU 0357017 hydrochloride
  64. BCC7766 VU 0255035 VU 0255035
  65. BCC6752 3'-Fluorobenzylspiperone maleate 3'-Fluorobenzylspiperone maleate
  66. BCC6637 MDL 72832 hydrochloride Potent 5-HT1A ligand MDL 72832 hydrochloride
  67. BCC4563 Neostigmine Bromide Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis. Neostigmine Bromide
  68. BCC6353 PAOPA PAOPA
  69. BCC6360 J 147 J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease (AD). J 147
  70. BCC1968 ST-836 ST-836 is a dopamine receptor ligand; Antiparkinsonian agent. ST-836
  71. BCC6176 SR 16584 SR 16584
  72. BCC7278 Carmoxirole hydrochloride Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo. Carmoxirole hydrochloride
  73. BCC6693 NAN-190 hydrobromide NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A. NAN-190 hydrobromide
  74. BCC4148 Tarafenacin D-tartrate Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. Tarafenacin D-tartrate
  75. BCC7729 VU 0238429 VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. VU 0238429
  76. BCC4596 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU 0361737
  77. BCC1486 Clemizole hydrochloride Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM. Clemizole hydrochloride
  78. BCC1576 FK 3311 FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent. FK 3311
  79. BCC4210 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Agomelatine hydrochloride
  80. BCC7365 Desmethyl-YM 298198 Desmethyl-YM 298198
  81. BCC6609 L-CCG-l L-CCG-l
  82. BCC4544 Lafutidine Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion. Lafutidine
  83. BCC7024 AF-DX 384 AF-DX 384
  84. BCC1028 Myelin Basic Protein (87-99) Major antigenic component implicated in the pathophysiology of multiple sclerosis Myelin Basic Protein (87-99)
  85. BCC5669 DPPE fumarate DPPE fumarate
  86. BCC6183 Mephedrone hydrochloride Mephedrone hydrochloride
  87. BCC1068 Rocuronium Bromide Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation. Rocuronium Bromide
  88. BCC6293 CRANAD 2 CRANAD 2
  89. BCC5512 mAChR-IN-1 mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM. mAChR-IN-1
  90. BCC6627 Arecaidine but-2-ynyl ester tosylate Arecaidine but-2-ynyl ester tosylate
  91. BCC6707 5-Methylfurmethiodide 5-Methylfurmethiodide
  92. BCC7468 Sazetidine A dihydrochloride Sazetidine A dihydrochloride
  93. BCC2497 Clopidogrel Clopidogrel hydrogen sulfate is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots. Clopidogrel
  94. BCC6737 (±)-Vesamicol hydrochloride (±)-Vesamicol hydrochloride
  95. BCC6975 (RS)-PPG (RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity. (RS)-PPG
  96. BCN1058 Huperzine A (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A
  97. BCC6164 VU 0365114 VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. VU 0365114
  98. BCC1499 CP-809101 hydrochloride CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. CP-809101 hydrochloride
  99. BCC7366 YM 298198 hydrochloride YM 298198 hydrochloride
  100. BCC6790 (+)-UH 232 maleate (+)-UH 232 maleate
  101. BCC7099 5-Iodo-A-85380 dihydrochloride 5-Iodo-A-85380 dihydrochloride

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