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JAK/STAT Signaling

The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. The JAK-STAT signalling cascade consists of three main components: a cell surface receptor, a Janus kinase (JAK) and two Signal Transducer and Activator of Transcription (STAT) proteins. Disrupted or dysregulated JAK-STAT functionality can result in immune deficiency syndromes and cancers.

Products for JAK/STAT Signaling

  1. Cat.No. Product Name Information
  2. BCN5592 Butein Butein
  3. BCN2172 Canertinib Canertinib
  4. BCN3198 Corylifol A Corylifol A
  5. BCN2173 Gefitinib Orally active, selective EGFR inhibitor Gefitinib
  6. BCC1051 AG-18 EGFR/PDGFR-kinase inhibitor AG-18
  7. BCC1069 AP26113 Anaplastic lymphoma kinase (ALK) inhibitor AP26113
  8. BCC1074 WZ4002 Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent WZ4002
  9. BCC1075 WZ8040 EGFR T790M inhibitor,irreversible amd potent WZ8040
  10. BCC1118 Pelitinib (EKB-569) EGFR inhibitor,potent and irreversible Pelitinib (EKB-569)
  11. BCC1157 PD168393 EGFR inhibitor PD168393
  12. BCC1176 Stattic STAT3 inhibitor,small-molecule and potent Stattic
  13. BCC1188 CP-724714 HER2 inhibitor,potent and selective CP-724714
  14. BCC1252 AC480 (BMS-599626) HER1/2 inhibitor,selective and efficacious AC480 (BMS-599626)
  15. BCC1430 BMS-690514 HER/EGFR inhibitor BMS-690514
  16. BCC1490 CO-1686 (AVL-301) EGFR inhibitor CO-1686 (AVL-301)
  17. BCC1557 Erlotinib EGFR tyrosine kinase inhibitor Erlotinib
  18. BCC1591 Gefitinib hydrochloride Potent EGFR inhibitor Gefitinib hydrochloride
  19. BCC1639 Icotinib Hydrochloride EGFR inhibitor,potent and specific Icotinib Hydrochloride
  20. BCC2083 Lapatinib Ditosylate EGFR/HER2 inhibitor,potent and selective Lapatinib Ditosylate
  21. BCC2193 AG-490 JAK2, JAK3 inhibitor. Also EGFR-kinase inhibitor AG-490
  22. BCC2194 WP1066 JAK2/STAT3 inhibitor,cell-permeable WP1066
  23. BCC2202 WHI-P154 JAK3 kinase inhibitor; also induces differentiation of neural progenitor cells WHI-P154
  24. BCC2203 ZM 39923 HCl JAK3 inhibitor,potent and selective ZM 39923 HCl
  25. BCC2204 BMS-911543 JAK2 inhibitor,selective small molecule BMS-911543
  26. BCC2233 SMI-4a Selective, ATP-competitive Pim kinase inhibitor SMI-4a
  27. BCC2439 Cucurbitacin I Selective inhibitor of STAT3/JAK2 signaling Cucurbitacin I
  28. BCC2520 AEE788 (NVP-AEE788) Potent VEGFR and EGFR inhibitor AEE788 (NVP-AEE788)
  29. BCC3615 Compound 56 REGFR inhibitor Compound 56
  30. BCC3617 PD153035 hydrochloride Potent EGFR inhibitor PD153035 hydrochloride
  31. BCC3633 Lapatinib EGFR/HER2 inhibitor,potent,selective and reversible Lapatinib
  32. BCC3645 Erlotinib Hydrochloride Selective EGFR inhibitor Erlotinib Hydrochloride
  33. BCC3656 Afatinib (BIBW2992) Irreversible EGFR/HER2 inhibitor Afatinib (BIBW2992)
  34. BCC3683 Dacomitinib (PF299804, PF299) HER inhibitor Dacomitinib (PF299804, PF299)
  35. BCC3685 Neratinib (HKI-272) HER2/EGFR inhibitor,potent and irreversible Neratinib (HKI-272)
  36. BCC3701 NSC 74859 Stat3 inhibitor NSC 74859
  37. BCC3717 AG-1478 EGFR inhibitor,potent and selective AG-1478
  38. BCC3725 Varlitinib (ARRY334543) ErbB inhibitor Varlitinib (ARRY334543)
  39. BCC3726 ARRY-380 Tyrosine kinase HER2 and p95-HER2 inhibitor ARRY-380
  40. BCC3727 AST-1306 EGFR/HER2 inhibitor AST-1306
  41. BCC3734 AZD8931 (Sapitinib) ErbB inhibitor AZD8931 (Sapitinib)
  42. BCC4043 AST-1306 TsOH ErbB2 and EGFR inhibitor AST-1306 TsOH
  43. BCC4052 (3S,4S)-Tofacitinib (3S,4S)-Tofacitinib
  44. BCC4119 Mutant EGFR inhibitor Mutant EGFR inhibitor
  45. BCC4120 AZD-9291 Mutated forms EGFR inhibitor AZD-9291
  46. BCC4121 AZD-9291 mesylate third generation EGFRm inhibitor, oral and irreversible AZD-9291 mesylate
  47. BCC4267 (3S,4R)-Tofacitinib (3S,4R)-Tofacitinib
  48. BCC4268 (3R,4S)-Tofacitinib (3R,4S)-Tofacitinib
  49. BCC4472 OSI-420 EGFR inhibitor OSI-420
  50. BCC4473 Icotinib EGFR tyrosine kinase inhibitor Icotinib
  51. BCC5081 Niclosamide STAT3 and mTORC1 signaling inhibitor; antineoplastic against AML stem cells Niclosamide
  52. BCC5461 TCS-PIM-1-4a Pim inhibitor TCS-PIM-1-4a
  53. BCC5639 HO-3867 STAT3 inhibitor, selective HO-3867
  54. BCC6389 AZ5104 EGFR inhibitor AZ5104
  55. BCC6475 AZD3759 EGFR inhibitor,oral active AZD3759
  56. BCC6499 FLLL32 STAT3 inhibitor FLLL32
  57. BCC6547 GLPG0634 JAK1 inhibitor, potent and selective GLPG0634

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