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Catalog No. BCC6598
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10mg $215.00 Ship Within 7 Days
50mg $901.00 Ship Within 7 Days
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Quality Control of (RS)-4-Carboxy-3-hydroxyphenylglycine

Chemical structure


Biological Activity of (RS)-4-Carboxy-3-hydroxyphenylglycine

Broad spectrum EAA agonist/antagonist. Separate isomer (S)-4-Carboxy-3-hydroxyphenylglycine also available.

(RS)-4-Carboxy-3-hydroxyphenylglycine Dilution Calculator

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(RS)-4-Carboxy-3-hydroxyphenylglycine Molarity Calculator



Chemical Properties of (RS)-4-Carboxy-3-hydroxyphenylglycine

Cas No. 134052-66-7 SDF Download SDF
Synonyms (RS)-4C3HPG
Chemical Name 4-[amino(carboxy)methyl]-2-hydroxybenzoic acid
SMILES NC(C(O)=O)c1ccc(C(O)=O)c(O)c1
Standard InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15)
Formula C9H9NO5 M.Wt 211.17
Solubility Soluble to 100 mM in 1eq. NaOH
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (RS)-4-Carboxy-3-hydroxyphenylglycine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7355 mL 23.6776 mL 47.3552 mL 94.7104 mL 118.388 mL
5 mM 0.9471 mL 4.7355 mL 9.471 mL 18.9421 mL 23.6776 mL
10 mM 0.4736 mL 2.3678 mL 4.7355 mL 9.471 mL 11.8388 mL
50 mM 0.0947 mL 0.4736 mL 0.9471 mL 1.8942 mL 2.3678 mL
100 mM 0.0474 mL 0.2368 mL 0.4736 mL 0.9471 mL 1.1839 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (RS)-4-Carboxy-3-hydroxyphenylglycine

4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus.[Pubmed: 1385184]

The determination of the physiological role of glutamatergic metabotropic actions has been hampered by the lack of potent and specific antagonists. It has recently been reported that 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine) can antagonize metabotropic responses in the central nervous system. The effects of 4C3HPG on metabotropic responses evoked by trans-ACPD were investigated in CA3 pyramidal cells in hippocampal slice cultures. Our results show that in hippocampus 4C3HPG fails to antagonize responses mediated by metabotropic glutamate receptors.


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