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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Products for NF-κB

  1. Cat.No. Product Name Information
  2. BCN2695 Caffeic acid phenethyl ester Caffeic acid phenethyl ester
  3. BCN1184 Cardamonin Cardamonin
  4. BCN5504 Curcumin Antitumor, anti-inflammatory and antioxidant Curcumin
  5. BCN5649 Emodin Naturally occurring anthraquinone; displays anti-inflammatory, antitumor and neuroprotective activity Emodin
  6. BCN5984 Triptolide Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive Triptolide
  7. BCC1399 Bardoxolone Once-a-day treatment for CKD Bardoxolone
  8. BCC1408 Bay 65-1942 free base IKKβ kinase inhibitor,ATP-competitive Bay 65-1942 free base
  9. BCC1409 Bay 65-1942 HCl salt Bay 65-1942 HCl salt
  10. BCC1410 Bay 65-1942 R form IKKβ inhibitor, ATP-competitive and selective Bay 65-1942 R form
  11. BCC1423 BMS-345541 Selective allosteric inhibitor of IKK; anti-inflammatory BMS-345541
  12. BCC1478 Choline Fenofibrate Choline salt of fenofibric acid Choline Fenofibrate
  13. BCC1481 CID-2858522 NF-κB pathway inhibitor CID-2858522
  14. BCC1642 IKK-2 inhibitor VIII IKK-2 inhibitor,potent and selective IKK-2 inhibitor VIII
  15. BCC1643 IKK-3 Inhibitor IKK-3 Inhibitor IKK-3 Inhibitor
  16. BCC1772 MLN120B IκB Kinase β Inhibitor MLN120B
  17. BCC1779 MRT67307 SIK/TBK-1/IKKe inhibitor MRT67307
  18. BCC1978 TAK-242 S enantiomer TLR 4 signaling inhibitor TAK-242 S enantiomer
  19. BCC2007 Toll-like receptor modulator TLR antagonist Toll-like receptor modulator
  20. BCC2154 CUDC-907 Potent PI3K/HDAC inhibitor CUDC-907
  21. BCC2244 Bay 11-7821(BAY 11-7082) E2 ubiquitin (Ub) conjugating enzymes inhibitor Bay 11-7821(BAY 11-7082)
  22. BCC2249 QNZ (EVP4593) Potent NF-κB inhibitor QNZ (EVP4593)
  23. BCC2473 TPCA-1 IKK-2 inhibitor,potent and selective TPCA-1
  24. BCC3607 SR 11302 AP-1 transcription factor inhibitor SR 11302
  25. BCC4073 Resiquimod (R-848) Toll-like receptor 7 (TLR7) agonist; antiviral Resiquimod (R-848)
  26. BCC4554 SC-514 ATP-competitive IKK-2 inhibitor, orally active SC-514
  27. BCC4555 IKK-16 (IKK Inhibitor VII) Selective IκB kinase inhibitor IKK-16 (IKK Inhibitor VII)
  28. BCC4556 IMD 0354 IKKβ inhibitor IMD 0354
  29. BCC4609 Sodium 4-Aminosalicylate Sodium 4-Aminosalicylate
  30. BCC4610 JSH-23 NF-κB inhibitor JSH-23
  31. BCC4611 ML130 (Nodinitib-1) ML130 (Nodinitib-1)
  32. BCC4776 Dimethyl Fumarate Nrf2 pathway activator; neuroprotective Dimethyl Fumarate
  33. BCC4846 Sodium salicylate Sodium salicylate
  34. BCC5105 Bay 11-7085 NK-κB activation inhibitor Bay 11-7085
  35. BCC5448 SC75741 NF-κB inhibitor, potent SC75741
  36. BCC5514 IKKε-IN-1 IKKε-IN-1
  37. BCC5566 WS6 inducer of β cell proliferation WS6
  38. BCC5574 HPOB HDAC6 inhibitor, potent and selective HPOB
  39. BCC5650 LY2409881 LY2409881
  40. BCC5856 PR 39 (porcine) IκBα inhibitor PR 39 (porcine)
  41. BCC6130 PF 184 PF 184
  42. BCC6223 ACHP IκB kinase inhibitor ACHP
  43. BCC6766 Pyrrolidinedithiocarbamate ammonium Pyrrolidinedithiocarbamate ammonium
  44. BCC7175 Ro 106-9920 Ro 106-9920
  45. BCC7495 Withaferin A Withaferin A
  46. BCC7949 PS 1145 dihydrochloride Selective IKK inhibitor; orally active PS 1145 dihydrochloride

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