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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC4435 Nimesulide Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
BCC7281 3-MATIDA
BCC4825 Pizotifen Malate Pizotifen malate (BC-105 malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
BCC4909 Haloperidol Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
BCC1046 Parathyroid hormone (1-34) (human) Teriparatide is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.
BCC7606 bPiDDB
BCC7574 PHA 568487
BCC5943 Cocaine hydrochloride
BCC3794 Indomethacin Indomethacin (Indometacin) is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
BCC4424 Acemetacin Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
BCC7219 (+)-Anabasine hydrochloride
BCC4568 Decamethonium Bromide Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
BCC7842 JNJ 10181457 dihydrochloride
BCC7352 Conessine
BCC4214 Fluvoxamine Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
BCC5033 Amitriptyline HCl Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).
BCC7042 McN-A 343
BCC4561 Hexamethonium Bromide Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
BCC6742 trans-Triprolidine hydrochloride
BCC1567 EVP-6124 hydrochloride Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
BCC1566 EVP-6124 Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
BCC6607 (S)-3-Carboxy-4-hydroxyphenylglycine
BCC4525 Betahistine 2HCl Betahistine dihydrochloride is a potent, orally active histamine H1 receptor agonist and H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
BCC4530 Histamine 2HCl Histamine dihydrochloride is an endogenous metabolite.
BCC1191 Fluoxetine HCl Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.
BCC3833 Oxybutynin Oxybutynin is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM.
BCC7291 Carcinine ditrifluoroacetate
BCC7496 (+)-Tubocurarine chloride
BCC6731 Salsolinol-1-carboxylic acid
BCC2547 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
BCC5047 BRL-54443 BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.
BCC7345 Fenobam Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.
BCC4461 Domperidone Domperidone is a dopamine blocker and an antidopaminergic reagent.
BCC5037 Clozapine Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.
BCC4518 Cyclizine 2HCl Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.
BCC7866 Xanthurenic acid Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
BCC6740 Mepyramine maleate Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
BCN1098 Levodopa L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
BCC4566 Bethanechol chloride Bethanechol Chloride (Carbamyl-β-methylcholine chloride) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
BCC1010 alpha-Endorphin
BCC3728 Atropine sulfate monohydrate Atropine sulfate monohydrate (Atropine sulfate hydrate) is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
BCC4275 Glycopyrrolate Glycopyrrolate (Glycopyrronium bromide) is a muscarinic competitive antagonist used as an antispasmodic.
BCC7063 Citalopram hydrobromide Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
BCN2197 Acetylcholine chloride Acetylcholine chloride (ACh chloride) is a common neurotransmitter found in the central and peripheral nerve system.
BCC3783 Gabapentin Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog.
BCC7173 Zimelidine dihydrochloride
BCC7865 Cinnabarinic acid
BCC5058 SB742457 Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.
BCC4433 Mefenamic Acid Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
BCC4564 Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.
BCC6769 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
BCC4597 VU 0364770 VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.
BCC3716 Acetylcysteine Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.
BCC1215 Fluvoxamine maleate Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
BCN2195 Dopamine hydrochloride Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
BCC4436 Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.
BCC3767 Diphemanil Methylsulfate Diphemanil methylsulfate is a quaternary ammonium anticholinergic.
BCC6970 SIB 1893
BCC6526 SKF38393 HCl SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.
BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
BCC7577 VU 10010
BCC5517 TBPB TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
BCC2054 WAY-100635 maleate salt WAY-100635 maleate salt is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate salt has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate salt is also a potent dopamine D4 receptor agonist.
BCC4592 LY404039 LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor.
BCC7403 6-Hydroxydopamine hydrobromide Oxidopamine hydrobromide (6-OHDA hydrobromide), an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons.
BCC4590 NMDA (N-Methyl-D-aspartic acid) NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
BCC5490 Meclofenamate Sodium Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
BCC7383 VUF 5681 dihydrobromide
BCC7265 Paroxetine maleate
BCC5044 Urapidil HCl Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.
BCC4576 Gallamine Triethiodide Gallamine Triethiodide is a synthetic nondepolarizing blocking drug.
BCC4464 Pergolide mesylate Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
BCC4533 Ranitidine Hydrochloride Ranitidine hydrochloride is a histamine H2-receptor antagonist that inhibits stomach acid production.
BCC4465 Amantadine HCl Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.
BCC6801 MSOP MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
BCC4205 Risperidone hydrochloride Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
BCC4206 Risperidone mesylate Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
BCC5976 α-Conotoxin PIA
BCC1999 Tianeptine
BCC4462 Fenoldopam Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.
BCC7071 SKF 81297 hydrobromide
BCC7251 SKF 83959 hydrobromide
BCC6557 γDGG gamma-DGG is a competitive AMPA receptor blocker.
BCC6640 GBR 13069 dihydrochloride
BCC5130 Vanoxerine Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT).
BCC6676 GBR 12783 dihydrochloride GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
BCC5129 Vanoxerine dihydrochloride Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT).
BCC5380 GBR 12935 dihydrochloride GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor.
BCC7801 PG 01037 dihydrochloride
BCC6567 (±)-trans-ACPD trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.
BCC5209 Hydroxyzine Hydroxyzine is a histamine H1-receptor antagonist.
BCC5191 Loxoprofen Loxoprofen is a non-steroidal anti-inflammatory drug.
BCC7691 Astemizole Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects.
BCC4460 Chlorpromazine HCl Chlorpromazine Hydrochloride is an antagonist of the dopamine D2, 5HT2A, potassium channel and sodium channel. Chlorpromazine binds with D2 and 5HT2A with Kis of 363 nM and 8.3 nM, respectively.
BCC4109 Salicylic acid Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
BCC5676 Tiotidine Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors.
BCC7212 DCB
BCC7328 Immethridine dihydrobromide
BCC6880 Cyanopindolol hemifumarate