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TGF-β/Smad Signaling

he transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Products for TGF-β/Smad Signaling

    1. Cat.No. Product Name Information
    2. BCN5275 Chelerythrine Chelerythrine
    3. BCN2177 Dasatinib monohydrate Dasatinib monohydrate
    4. BCN5597 Epicatechin Epicatechin
    5. BCN6327 (-)-Epicatechin gallate (-)-Epicatechin gallate
    6. BCN4519 (-)-Epigallocatechin(EGC) (-)-Epigallocatechin(EGC)
    7. BCN6326 (-)-Epigallocatechin gallate Inhibits formation of amyloid fibrils (-)-Epigallocatechin gallate
    8. BCN4732 Narciclasine Antiproliferative agent; induces actin polymerization Narciclasine
    9. BCN1634 Tamoxifen Tamoxifen
    10. BCC1100 Enzastaurin (LY317615) PKC beta inhibitor,potent and selective Enzastaurin (LY317615)
    11. BCC1115 Imatinib Mesylate (STI571) PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit Imatinib Mesylate (STI571)
    12. BCC1166 Saracatinib (AZD0530) Src/Abl inhibitor,potent and selective Saracatinib (AZD0530)
    13. BCC1167 Bosutinib (SKI-606) Dual Src-Abl inhibitor; antiproliferative Bosutinib (SKI-606)
    14. BCC1273 Y-27632 dihydrochloride ROCK1 inhibitor Y-27632 dihydrochloride
    15. BCC1281 Dasatinib (BMS-354825) Src and BCR-Abl inhibitor Dasatinib (BMS-354825)
    16. BCC1318 A 77-01 Potent ALK5 inhibitor A 77-01
    17. BCC1319 A 83-01 ALK-5 inhibitor A 83-01
    18. BCC1480 chroman 1 ROCK II inhibitor, highly potent and selective chroman 1
    19. BCC1538 DPH c-ABL activitor DPH
    20. BCC1635 Hydroxyfasudil Rho-kinase inhibitor and vasodilator Hydroxyfasudil
    21. BCC1636 Hydroxyfasudil hydrochloride Cell-permeable, selective Rho-kinase inhibitor Hydroxyfasudil hydrochloride
    22. BCC1695 LDN193189 Hydrochloride ALK inhibitor,potent and selective LDN193189 Hydrochloride
    23. BCC1799 NG25 NG25
    24. BCC1801 Nilotinib monohydrochloride monohydrate Nilotinib monohydrochloride monohydrate
    25. BCC1887 RepSox ALK5 inhibitor,potent and selective RepSox
    26. BCC1903 RKI-1447 Potent ROCK1/ROCK2 inhibitor RKI-1447
    27. BCC1905 ROCK inhibitor Potent and highly selective ROCK inhibitor; orally active ROCK inhibitor
    28. BCC1930 SB-505124 hydrochloride ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selective SB-505124 hydrochloride
    29. BCC1938 SD-208 TGF-βR I kinase inhibitor SD-208
    30. BCC1954 SLx-2119 Selective ROCK2 inhibitor SLx-2119
    31. BCC2522 Ponatinib (AP24534) Potent multi-kinase and pan-Bcr-Abl inhibitor Ponatinib (AP24534)
    32. BCC2525 Thiazovivin Improves the efficiency of fibroblast reprogramming and induction of iPSCs Thiazovivin
    33. BCC2531 SB525334 (TGF-beta1) receptor inhibitor SB525334
    34. BCC2532 GSK429286A Selective Rho-kinase (ROCK) inhibitor GSK429286A
    35. BCC2542 Fasudil (HA-1077) HCl Inhibitor of cyclic nucleotide dependent- and Rho-kinases Fasudil (HA-1077) HCl
    36. BCC3643 Nilotinib(AMN-107) Bcr-Abl kinase inhibitor,selective Nilotinib(AMN-107)
    37. BCC3658 SB 431542 Induces proliferation, differentiation and sheet formation of ESC-derived endothelial cells SB 431542
    38. BCC3666 GW788388 ALK5 inhibitor,potent and selective GW788388
    39. BCC3687 LDN-193189 ALK inhibitor,potent and selective LDN-193189
    40. BCC3693 CX-4945 (Silmitasertib) CK2 inhibitor CX-4945 (Silmitasertib)
    41. BCC3703 Go 6976 PKCα/PKCβ1 inhibitor Go 6976
    42. BCC3704 GF 109203X Protein kinase C inhibitor GF 109203X
    43. BCC3705 Go 6983 Broad spectrum PKC inhibitor Go 6983
    44. BCC3706 K-252c Protein kinase C inhibitor K-252c
    45. BCC3709 LY2157299 TGF-βR1 inhibitor,potent and selective LY2157299
    46. BCC3806 LY2109761 TβRI/II kinase inhibitor LY2109761
    47. BCC3857 Sotrastaurin (AEB071) PKC inhibitor Sotrastaurin (AEB071)
    48. BCC3890 Adaphostin p210bcr/abl kinase inhibitor Adaphostin
    49. BCC3891 GNF 2 Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity GNF 2
    50. BCC3892 GNF 5 Bcr-Abl inhibitor GNF 5
    51. BCC3893 1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl 1-Naphthyl PP1
    52. BCC3894 PD 180970 p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT PD 180970
    53. BCC3895 PPY A Potent inhibitor of Abl T315l mutant and wild-type Abl kinases PPY A
    54. BCC3999 PD173955 Dual Src/Abl kinase inhibitor, ATP-competitive, PD173955
    55. BCC4003 ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMζ ZIP
    56. BCC4036 Bafetinib (INNO-406) Bcr-Abl/Lyn tyrosine kinase inhibitor Bafetinib (INNO-406)
    57. BCC4186 Y-39983 dihydrochloride ROCK family inhibitor Y-39983 dihydrochloride
    58. BCC4295 Ro 31-8220 pan-PKC inhibitor Ro 31-8220
    59. BCC4301 Y-27632 ROCK inhibitor,potent and selective Y-27632
    60. BCC4302 SR-3677 Potent, selective Rho-kinase (ROCK) inhibitor SR-3677
    61. BCC4390 DCC-2036 (Rebastinib) Bcr-Abl inhibitor DCC-2036 (Rebastinib)
    62. BCC4998 Dequalinium Chloride anti-tumor agent and PKC inhibitor Dequalinium Chloride
    63. BCC5084 K02288 Type 1 BMP receptor inhibitor K02288
    64. BCC5085 LY364947 inhibitor of TGF-β type I receptor kinase domain LY364947
    65. BCC5086 Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo Pirfenidone
    66. BCC5178 GSK269962A Potent and selective ROCK inhibitor GSK269962A
    67. BCC5329 DMH-1 Selective ALK2 inhibitor DMH-1
    68. BCC5330 LDN-212854 BMP receptor inhibitor,potent and selective LDN-212854
    69. BCC5331 ML347 Potent and selective ALK1 and ALK2 inhibitor ML347
    70. BCC5350 Midostaurin (PKC412) Broad spectrum protein kinase inhibitor Midostaurin (PKC412)
    71. BCC5501 K-115 free base K-115 free base
    72. BCC5619 Bryostatin 2 Protein kinase C activator Bryostatin 2
    73. BCC5620 Bryostatin 3 Potent protein kinase C activator Bryostatin 3
    74. BCC5811 PKC β pseudosubstrate Selective cell-permeable PKC inhibitor peptide (attached to vector) PKC β pseudosubstrate
    75. BCC5830 PKC fragment (530-558) PKC fragment (530-558)
    76. BCC5835 [Ala107]-MBP (104-118) Protein kinase C inhibitor [Ala107]-MBP (104-118)
    77. BCC5836 [Ala113]-MBP (104-118) Protein kinase C inhibitor [Ala113]-MBP (104-118)
    78. BCC6409 ITD 1 The first selective TGFβ inhibitor ITD 1
    79. BCC6414 LX7101 HCL Dual LIM-kinase and ROCK inhibitor LX7101 HCL
    80. BCC6467 EW-7197 Selective inhibitor of TGF-β type I receptor kinase EW-7197
    81. BCC6643 SC-10 Protein kinase C activator SC-10
    82. BCC6646 SC-9 Protein kinase C activator SC-9
    83. BCC6687 C-1 Protein kinase C inhibitor C-1
    84. BCC6718 (±)-Palmitoylcarnitine chloride Protein kinase C inhibitor (±)-Palmitoylcarnitine chloride
    85. BCC6729 D-erythro-Sphingosine (synthetic) Protein kinase C inhibitor D-erythro-Sphingosine (synthetic)
    86. BCC6778 Dihydrosphingosine Protein kinase C inhibitor Dihydrosphingosine
    87. BCC7122 Ro 32-0432 hydrochloride Potent, orally active PKC inhibitor Ro 32-0432 hydrochloride
    88. BCC7127 Rottlerin Stimulates autophagy Rottlerin
    89. BCC7131 Calphostin C Potent, selective and photo-dependent PKC inhibitor Calphostin C
    90. BCC7343 Bryostatin 1 Protein kinase C activator Bryostatin 1
    91. BCC7363 CGP 53353 CGP 53353
    92. BCC7564 FR 236924 PKC-ε activator, selective FR 236924
    93. BCC7868 Bisindolylmaleimide II Potent PKC inhibitor and nicotinic receptor antagonist Bisindolylmaleimide II
    94. BCC7870 Phorbol 12,13-dibutyrate Protein kinase C activator Phorbol 12,13-dibutyrate
    95. BCC7969 LY 333531 hydrochloride LY 333531 hydrochloride

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