GPCR/G protein
G protein–coupled receptors (GPCRs) which are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors, that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
Products for GPCR/G protein
- GIP Receptor(2)
- FFAR1 (GPR40)(7)
- 5-HT Receptor(238)
- Urotensin-II Receptor(10)
- CCK2 Receptors(7)
- P2Y Receptor(25)
- EP4 Receptor(3)
- CRF1 Receptors(6)
- Melatonin Receptors(9)
- LPL Receptor(1)
- Adenosine Receptor(54)
- VIP Receptors(7)
- OX Receptor(15)
- Chemokine Receptors(16)
- Neurotensin Receptors(7)
- Prostanoid Receptors(21)
- CCK1 Receptors(5)
- Adrenergic Receptor(136)
- GPR119(5)
- Calcium-Sensing Receptor(3)
- Cannabinoid Receptor(36)
- Angiotensin Receptor(21)
- GPR120(2)
- Protease-Activated Receptors(9)
- PAF Receptors(3)
- Sigma Receptor(24)
- NK3 Receptor(6)
- NPY Receptors(23)
- Glucagon Receptor(16)
- Leukotriene Receptor(9)
- Bombesin Receptors(14)
- Sphingosine(14)
- CXCR(16)
- NOP Receptor(21)
- GPR55(5)
- Galanin Receptors(11)
- Endothelin Receptor(11)
- GPR35(7)
- Glucocorticoid Receptor(17)
- Calcitonin and Related Receptors(10)
- Bradykinin Receptors(12)
- mGluR(11)
- Adenosine Kinase(2)
- GPR109A(2)
- GPCR19(1)
- Non-selective CRF(7)
- LTD4 Receptor(1)
- Secretin Receptors(1)
- Melanocortin (MC) Receptors(16)
- ETB Receptors(5)
- NK2 Receptors(7)
- LPA Receptor(5)
- S1P receptor inhibitor(5)
- CCR2(5)
- Hydroxycarboxylic Acid Receptors(5)
- PACAP Receptors(3)
- Melanin-concentrating Hormone Receptors(7)
- Vasopressin Receptor(10)
- Somatostatin Receptor(15)
- TSH Receptor(1)
- Peptide Receptors(8)
- Ghrelin Receptors(9)
- ETA Receptors(3)
- Orphan 7-TM Receptors(6)
- Oxytocin Receptors(4)
- Ras(6)
- Heterotrimeric(1)
- CysLT1 receptor(1)
- Motilin Receptor(4)
- Acetylcholine(3)
- Prostaglandin Receptor(4)
- GHSR(4)
- EBI2/GPR183(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- Orexin(3)
- Apelin Receptor(5)
- CRF2 Receptors(3)
- Calcimimetic Agent(2)
- Adrenergic Transporters(5)
- CaSR(3)
- EP1 Receptor(1)
- Sensory Neuron-Specific Receptors(1)
- 17,20-lyase(3)
- Adenosine Deaminase(3)
- NK Receptor(1)
- PGD2 Receptor(1)
- GLUT1(1)
- RGS(2)
- GPR44(1)
- Adiponectin Receptor(1)
- ERRγ(1)
- Cat.No. Product Name Information
- BCC5961 Neuropeptide W-23 (human) Neuropeptide W-23(human), the active form of Neuropeptide W, is an endogenous ligand for NPBW1 and NPBW2.
- BCC7889 Prostaglandin F2α Dinoprost tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
- BCC7663 PSN 375963 hydrochloride
- BCC4291 Prasugrel hydrochloride Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and prodrug, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
- BCC4292 Prasugrel Maleic acid Prasugrel (PCR 4099) Maleic acid is a thienopyridine and prodrug, inhibits platelet function. Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
- BCC4356 Sotalol
- BCC5842 Neurotensin Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).
- BCC5300 Pasireotide Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
- BCC7098 SDZ 21009
- BCC7843 16,16-Dimethyl Prostaglandin E2 16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway.
- BCC1822 ONO-AE3-208 High affinity and selective EP4 antagonist,ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
- BCC7595 SB 399885 hydrochloride SB-399885 hydrochloride is a 5-HT6 receptor antagonist.
- BCC7990 DR 4485 hydrochloride
- BCC7118 HEMADO HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype.
- BCC6833 Cirazoline hydrochloride Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).
- BCC7527 DSP-4 DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC).
- BCC7310 FPL 55712
- BCC6733 MDL 72222 Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.
- BCC5806 BAM (8-22)
- BCC7160 N6-Cyclopentyladenosine N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively.
- BCC6809 (S)-(-)-Propranolol hydrochloride
- BCC4325 Clonidine HCl Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
- BCC5981 d[Leu4,Lys8]-VP
- BCC5925 DOI hydrochloride
- BCC1979 TAK-700 salt
- BCC4349 Formoterol Hemifumarate Formoterol fumarate(Foradil) is a potent, selective and long-acting β2-adrenoceptor agonist.
- BCC4595 VU 0357121 VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.
- BCC5867 K 41498
- BCC6022 JKC 363
- BCC5290 Kobe0065 Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.
- BCC5879 MRS 2365
- BCC7961 GW 627368 GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively.
- BCC7747 NPY 5RA972
- BCC1142 Macitentan Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
- BCC7805 SF 11
- BCC2551 AM1241 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
- BCC7900 TC-O 9311 TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM.
- BCC7750 SGS 518 oxalate
- BCC7572 BMS CCR2 22 BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).
- BCC4087 Angiotensin II human Angiotensin II human (Angiotensin II) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis.
- BCC7883 VPC 23019 VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).
- BCC7239 PSB 11 hydrochloride
- BCC5291 kobe2602 kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM.
- BCC7850 BMS 470539 dihydrochloride Potent, selective MC1 receptor agonist
- BCC5932 Bay 55-9837
- BCC1932 SCH 527123 Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly.
- BCC1933 SCH 563705 SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.
- BCC7436 ST 91
- BCC7713 SB 657510 SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
- BCC7661 NS 304 Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
- BCC5871 Galnon
- BCC1398 BAN ORL 24
- BCC5794 2-Methylthioadenosine diphosphate trisodium salt
- BCC6025 MCL 0020
- BCC7381 (±)-AC 7954 hydrochloride
- BCC1448 Calcium-Sensing Receptor Antagonists I Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors.
- BCC5793 [Orn8]-Urotensin II
- BCC7958 TC OT 39
- BCC1931 SB-674042 SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
- BCC7658 SNAP 94847 hydrochloride SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
- BCC6316 TC-G 1001
- BCC5391 Dobutamine hydrochloride Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
- BCN1940 Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
- BCC4771 Cortisone acetate Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
- BCN2203 Corticosterone Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
- BCN2192 Hydrocortisone Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
- BCC4830 Prednisolone Prednisolone is a glucocorticoid with the general properties of the corticosteroids.
- BCC7810 NIDA 41020
- BCC4030 Vilanterol Vilanterol (GW642444) is a long-acting β2-adrenoceptor (β2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.
- BCC4031 Vilanterol trifenatate Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.
- BCC1593 glucagon receptor antagonists 1 Glucagon receptor antagonists-1 is a highly potent glucagon receptor antagonist.
- BCC5904 Bombinakinin M
- BCC5678 Pronethalol hydrochloride
- BCC4328 Isoprenaline HCl Isoprenaline hydrochloride is a non-selective beta-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities.
- BCC4348 Epinephrine Bitartrate L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.
- BCN2191 Adrenaline L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.
- BCC4338 Salbutamol Sulfate Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
- BCC7666 ATC 0065 Potent and selective MCH1 antagonist
- BCC7657 ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
- BCC4082 Tizanidine Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
- BCC4767 Budesonide Budesonide is a glucocortical steroid with potent anti-inflammatory activity.
- BCC7897 GW 803430 GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.
- BCC6466 Carteolol HCl Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma.
- BCC7562 CJ 033466
- BCC6168 Psilocin
- BCC4339 Tetrahydrozoline HCl Tetrahydrozoline (hydrochloride) is a α-adrenoceptor agonist.
- BCC7240 PSB 36
- BCC5894 Motilin (human, porcine) Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
- BCC5877 [Ala11,D-Leu15]-Orexin B
- BCC7163 CV 1808
- BCC7313 O-1918
- BCC6807 ICI 89406
- BCC4973 Ticlopidine HCl Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
- BCC2514 Tranilast Tranilast is an antiallergic agent.
- BCC1845 Pentostatin Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM.
- BCC6653 Cinanserin hydrochloride Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
- BCC6647 Cimaterol
- BCC7947 (+)-Fluprostenol
- BCC6828 Palmitoylethanolamide Impulsin (AM 3112) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.
- BCC1450 Capadenoson Capadenoson is a selective agonist of adenosine-A1 receptor.