GPCR/G protein
G protein–coupled receptors (GPCRs) which are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors, that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
Products for GPCR/G protein
- GIP Receptor(2)
- FFAR1 (GPR40)(7)
- 5-HT Receptor(238)
- Urotensin-II Receptor(10)
- CCK2 Receptors(7)
- P2Y Receptor(25)
- EP4 Receptor(3)
- CRF1 Receptors(6)
- Melatonin Receptors(9)
- LPL Receptor(1)
- Adenosine Receptor(54)
- VIP Receptors(7)
- OX Receptor(15)
- Chemokine Receptors(16)
- Neurotensin Receptors(7)
- Prostanoid Receptors(21)
- CCK1 Receptors(5)
- Adrenergic Receptor(136)
- GPR119(5)
- Calcium-Sensing Receptor(3)
- Cannabinoid Receptor(36)
- Angiotensin Receptor(21)
- GPR120(2)
- Protease-Activated Receptors(9)
- PAF Receptors(3)
- Sigma Receptor(24)
- NK3 Receptor(6)
- NPY Receptors(23)
- Glucagon Receptor(16)
- Leukotriene Receptor(9)
- Bombesin Receptors(14)
- Sphingosine(14)
- CXCR(16)
- NOP Receptor(21)
- GPR55(5)
- Galanin Receptors(11)
- Endothelin Receptor(11)
- GPR35(7)
- Glucocorticoid Receptor(17)
- Calcitonin and Related Receptors(10)
- Bradykinin Receptors(12)
- mGluR(11)
- Adenosine Kinase(2)
- GPR109A(2)
- GPCR19(1)
- Non-selective CRF(7)
- LTD4 Receptor(1)
- Secretin Receptors(1)
- Melanocortin (MC) Receptors(16)
- ETB Receptors(5)
- NK2 Receptors(7)
- LPA Receptor(5)
- S1P receptor inhibitor(5)
- CCR2(5)
- Hydroxycarboxylic Acid Receptors(5)
- PACAP Receptors(3)
- Melanin-concentrating Hormone Receptors(7)
- Vasopressin Receptor(10)
- Somatostatin Receptor(15)
- TSH Receptor(1)
- Peptide Receptors(8)
- Ghrelin Receptors(9)
- ETA Receptors(3)
- Orphan 7-TM Receptors(6)
- Oxytocin Receptors(4)
- Ras(6)
- Heterotrimeric(1)
- CysLT1 receptor(1)
- Motilin Receptor(4)
- Acetylcholine(3)
- Prostaglandin Receptor(4)
- GHSR(4)
- EBI2/GPR183(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- Orexin(3)
- Apelin Receptor(5)
- CRF2 Receptors(3)
- Calcimimetic Agent(2)
- Adrenergic Transporters(5)
- CaSR(3)
- EP1 Receptor(1)
- Sensory Neuron-Specific Receptors(1)
- 17,20-lyase(3)
- Adenosine Deaminase(3)
- NK Receptor(1)
- PGD2 Receptor(1)
- GLUT1(1)
- RGS(2)
- GPR44(1)
- Adiponectin Receptor(1)
- ERRγ(1)
- Cat.No. Product Name Information
- BCC6861 Xamoterol hemifumarate
- BCC6256 SB 706375
- BCC4218 Doxazosin Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
- BCC5715 Somatostatin 1-28
- BCC7522 PAF (C16) Endogenous platelet-activating factor (PAF)
- BCC5792 Sauvagine
- BCC4963 Alprostadil Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
- BCC5809 GRP (porcine)
- BCC6652 5-Carboxamidotryptamine maleate
- BCC6708 PRE-084 hydrochloride PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.
- BCC4203 TAK-700 R-form
- BCC4358 Indacaterol Maleate Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
- BCC7090 Rimcazole dihydrochloride
- BCC5963 [Nle4,D-Phe7]-α-MSH Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH), for gaining a tan.
- BCC5711 Pancreatic Polypeptide (human) Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
- BCC4079 Detomidine Detomidine produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist Target: α2-adrenergic agonist Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses.
- BCC6967 SR 57227 hydrochloride
- BCC1257 Doxazosin Mesylate Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
- BCC5985 [Orn5]-URP
- BCC7247 Iloprost Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.
- BCC5200 SB-334867 free base SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.
- BCC6798 Idazoxan hydrochloride Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism.
- BCC5499 RG7090 Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
- BCC4907 Fluticasone propionate Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
- BCN4344 Grifolic acid
- BCC6875 Imiloxan hydrochloride
- BCC7191 Seglitide
- BCC2494 Alfuzosin HCl Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
- BCC4080 Alfuzosin Alfuzosin is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
- BCC5832 Neuromedin C (porcine)
- BCC5431 Bambuterol Bambuterol ((±)-Bambuterol; KWD-2183) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.
- BCC7399 LP 44
- BCC7479 Nefazodone hydrochloride Nefazodone hydrochloride is an antidepressant drug.
- BCC4223 Perindopril Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
- BCC2256 Methylprednisolone Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
- BCC5643 Octreotide acetate Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production.
- BCC5389 APD668 APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.
- BCC6341 4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM.
- BCC5712 CGRP (rat)
- BCC7693 Cyclosomatostatin Non-selective sst receptor antagonist
- BCC4486 Mifepristone Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
- BCC7018 CP 94253 hydrochloride
- BCC5663 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.
- BCC6210 SHA 68 SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
- BCC6208 S 32212 hydrochloride
- BCC5775 UFP-101
- BCC7854 PF9 tetrasodium salt
- BCC4507 OC000459 OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM. Phase 2. Cas: 851723-84-7
- BCC7746 PF 514273
- BCC4111 NBI-74330 NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
- BCC1946 Setiptiline maleate Setiptiline is a serotonin receptor antagonist.
- BCC5408 PSN632408 PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively.
- BCC6664 1,3-Dipropyl-8-phenylxanthine
- BCC7142 GR 125487 sulfamate
- BCC5929 M617
- BCC7795 SKF 86466 hydrochloride
- BCC1364 Anamorelin hydrochloride Anamorelin hydrochloride is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
- BCC5021 Azilsartan Medoxomil Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
- BCC4089 Azilsartan medoxomil monopotassium Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
- BCC1736 Medetomidine Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively).
- BCC4351 Medetomidine HCl Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.
- BCC6047 C 021 dihydrochloride Potent CCR4 antagonist
- BCC7594 SB 699551
- BCC6149 TC-MCH 7c TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively.
- BCC6387 AMG837 AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
- BCC5973 [Ala2,8,9,11,19,22,24,25,27,28]-VIP
- BCC5710 CRF (human, rat) Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
- BCC4411 Org 27569 Org 27569 is a potent CB1 receptor allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling.
- BCC5912 Obestatin (rat)
- BCC2011 Tozadenant Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
- BCC7214 Ritanserin Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
- BCC1752 MK 0893 MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.
- BCC5841 Neuromedin B (porcine) Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
- BCC8036 TCS 3035 GPR35 agonist
- BCC5122 Almorexant Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.
- BCC4599 CTEP (RO4956371) CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
- BCC7802 WAY 207024 dihydrochloride GnRH receptor antagonist
- BCC1531 Dipraglurant Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.
- BCC7413 ZK 756326
- BCC7826 YIL 781
- BCC6278 ML 221 ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
- BCC5827 Glucagon-like peptide 1 (1-37) (human, rat) Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.
- BCC4189 S1RA S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
- BCC6899 CP 93129 dihydrochloride
- BCC5917 UFP 803
- BCC1358 AMD-070 hydrochloride AMD-070 (hydrochloride) is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
- BCC6163 26RFa
- BCC4083 L-(-)-α-Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.
- BCC1102 GW9508 GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities.
- BCC1646 INCB 3284 dimesylate INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.
- BCC5960 Galanin (porcine)
- BCC1710 LUF6000 LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).
- BCC6797 Efaroxan hydrochloride
- BCC4346 Detomidine HCl Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist Target: α2-adrenergic agonist Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses.
- BCC4110 SCH 546738 SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
- BCC5314 Atosiban Atosiban(RW22164; Tractocile) is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).
- BCC5727 α-helical CRF 9-41 CRF receptor antagonist
- BCC5930 M871
- BCC5962 α-CGRP (human)
- BCC7723 W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.