BAN ORL 24NOP receptor antagonist, potent and selective CAS# 475150-69-7 |
- MCOPPB trihydrochloride
Catalog No.:BCC4161
CAS No.:1108147-88-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 475150-69-7 | SDF | Download SDF |
| PubChem ID | 56840444 | Appearance | Powder |
| Formula | C27H37Cl2N3O2 | M.Wt | 506.51 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | (2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide;dihydrochloride | ||
| SMILES | C1CC(N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl | ||
| Standard InChIKey | NEEVITHVDIQNJY-KHZPMNTOSA-N | ||
| Standard InChI | InChI=1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27;;/h1-5,8-11,25H,6-7,12-21H2,(H,28,31);2*1H/t25-;;/m1../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
BAN ORL 24 Dilution Calculator
BAN ORL 24 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9743 mL | 9.8715 mL | 19.7429 mL | 39.4859 mL | 49.3574 mL |
| 5 mM | 0.3949 mL | 1.9743 mL | 3.9486 mL | 7.8972 mL | 9.8715 mL |
| 10 mM | 0.1974 mL | 0.9871 mL | 1.9743 mL | 3.9486 mL | 4.9357 mL |
| 50 mM | 0.0395 mL | 0.1974 mL | 0.3949 mL | 0.7897 mL | 0.9871 mL |
| 100 mM | 0.0197 mL | 0.0987 mL | 0.1974 mL | 0.3949 mL | 0.4936 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
BAN ORL24 is a selective inhibitor of NOP with pK(i) value of 9.62 [1].
NOP (nociceptin/orphanin FQ (N/OFQ) peptide receptor) is a G protein coupled receptor and plays an important role in regulating many brain activities[2].
BAN ORL24 is a potent NOP inhibitor and has the highest affinity compared with other NOP inhibitors. When tested with CHO (hNOP) cells, administration of BAN ORL24 showed high affinity to cell membrane and higher selective compared with classical opioid receptors [1]. In SG neuron heterologously expressing NOP receptors with an enhanced basal facilitation ratio, BAN ORL24 treatment for 50 seconds enhanced the Ca2+ current amplitude for both prepulse and postpulse [3].
In the mouse tail withdrawal assay, administration of BAN ORL24 (10 mg/kg) combined with N/OFQ (1 nmol) antagonized the pronociceptive and antinociceptive effects of given supraspinally and spinally, respectively. Under the same experimental conditions BAN ORL24 did not affect the antinociceptive action of 3 nmol endomorphin-1 injected intrathecally [1].
References:
[1].Fischetti, C., et al., Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24. Eur J Pharmacol, 2009. 614(1-3): p. 50-7.
[2].Donica, C.L., et al., Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Mol Pharmacol, 2013. 83(5): p. 907-18.
[3].Mahmoud, S., et al., Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol, 2010. 77(5): p. 804-17.
- Galnon
Catalog No.:BCC5871
CAS No.:475115-35-6
- ZSTK474
Catalog No.:BCC3657
CAS No.:475110-96-4
- Tivozanib (AV-951)
Catalog No.:BCC1179
CAS No.:475108-18-0
- NS 304
Catalog No.:BCC7661
CAS No.:475086-01-2
- Nuciferine
Catalog No.:BCN1223
CAS No.:475-83-2
- Glaucine
Catalog No.:BCN2550
CAS No.:475-81-0
- Aristolochic acid B
Catalog No.:BCN6263
CAS No.:475-80-9
- Liriodenine
Catalog No.:BCN5532
CAS No.:475-75-2
- (+)-Isocorynoline
Catalog No.:BCN2361
CAS No.:475-67-2
- H-N-Me-Pro-OH
Catalog No.:BCC3351
CAS No.:475-11-6
- SB 657510
Catalog No.:BCC7713
CAS No.:474960-44-6
- ST 91
Catalog No.:BCC7436
CAS No.:4749-61-5
- 2-Methylthioadenosine diphosphate trisodium salt
Catalog No.:BCC5794
CAS No.:475193-31-8
- A-317491
Catalog No.:BCC1320
CAS No.:475205-49-3
- Sorafenib Tosylate
Catalog No.:BCC3654
CAS No.:475207-59-1
- Nogo-66 (1-40)
Catalog No.:BCC5862
CAS No.:475221-20-6
- CORM-3
Catalog No.:BCC5108
CAS No.:475473-26-8
- Aleglitazar
Catalog No.:BCC1337
CAS No.:475479-34-6
- NVP-ADW742
Catalog No.:BCC4553
CAS No.:475488-23-4
- NVP-AEW541
Catalog No.:BCC1180
CAS No.:475489-16-8
- MCL 0020
Catalog No.:BCC6025
CAS No.:475498-26-1
- Isotretinoin
Catalog No.:BCC2284
CAS No.:4759-48-2
- Xylotriose
Catalog No.:BCN8428
CAS No.:47592-59-6
- Lycorine
Catalog No.:BCN2409
CAS No.:476-28-8
