GPCR/G protein
G protein–coupled receptors (GPCRs) which are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors, that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
Products for GPCR/G protein
- GIP Receptor(2)
- FFAR1 (GPR40)(7)
- 5-HT Receptor(238)
- Urotensin-II Receptor(10)
- CCK2 Receptors(7)
- P2Y Receptor(25)
- EP4 Receptor(3)
- CRF1 Receptors(6)
- Melatonin Receptors(9)
- LPL Receptor(1)
- Adenosine Receptor(54)
- VIP Receptors(7)
- OX Receptor(15)
- Chemokine Receptors(16)
- Neurotensin Receptors(7)
- Prostanoid Receptors(21)
- CCK1 Receptors(5)
- Adrenergic Receptor(136)
- GPR119(5)
- Calcium-Sensing Receptor(3)
- Cannabinoid Receptor(36)
- Angiotensin Receptor(21)
- GPR120(2)
- Protease-Activated Receptors(9)
- PAF Receptors(3)
- Sigma Receptor(24)
- NK3 Receptor(6)
- NPY Receptors(23)
- Glucagon Receptor(16)
- Leukotriene Receptor(9)
- Bombesin Receptors(14)
- Sphingosine(14)
- CXCR(16)
- NOP Receptor(21)
- GPR55(5)
- Galanin Receptors(11)
- Endothelin Receptor(11)
- GPR35(7)
- Glucocorticoid Receptor(17)
- Calcitonin and Related Receptors(10)
- Bradykinin Receptors(12)
- mGluR(11)
- Adenosine Kinase(2)
- GPR109A(2)
- GPCR19(1)
- Non-selective CRF(7)
- LTD4 Receptor(1)
- Secretin Receptors(1)
- Melanocortin (MC) Receptors(16)
- ETB Receptors(5)
- NK2 Receptors(7)
- LPA Receptor(5)
- S1P receptor inhibitor(5)
- CCR2(5)
- Hydroxycarboxylic Acid Receptors(5)
- PACAP Receptors(3)
- Melanin-concentrating Hormone Receptors(7)
- Vasopressin Receptor(10)
- Somatostatin Receptor(15)
- TSH Receptor(1)
- Peptide Receptors(8)
- Ghrelin Receptors(9)
- ETA Receptors(3)
- Orphan 7-TM Receptors(6)
- Oxytocin Receptors(4)
- Ras(6)
- Heterotrimeric(1)
- CysLT1 receptor(1)
- Motilin Receptor(4)
- Acetylcholine(3)
- Prostaglandin Receptor(4)
- GHSR(4)
- EBI2/GPR183(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- Orexin(3)
- Apelin Receptor(5)
- CRF2 Receptors(3)
- Calcimimetic Agent(2)
- Adrenergic Transporters(5)
- CaSR(3)
- EP1 Receptor(1)
- Sensory Neuron-Specific Receptors(1)
- 17,20-lyase(3)
- Adenosine Deaminase(3)
- NK Receptor(1)
- PGD2 Receptor(1)
- GLUT1(1)
- RGS(2)
- GPR44(1)
- Adiponectin Receptor(1)
- ERRγ(1)
- Cat.No. Product Name Information
- BCC5662 IPAG
- BCC6987 SB 216641 hydrochloride
- BCC6010 Cortistatin 14 Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus.
- BCC6968 SC 19220
- BCC5892 GLP-2 (rat)
- BCC1380 Atrasentan hydrochloride Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA.
- BCC8020 Prosaptide TX14(A)
- BCC1107 4-Acetyl Ramelteon
- BCC7040 SB 221284
- BCC6706 Methiothepin maleate
- BCC7633 SN 003
- BCC7395 T 98475
- BCC7361 NNC 26-9100
- BCC7559 LY 334370 hydrochloride
- BCC6035 SB 243213 dihydrochloride SB 243213 hydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.
- BCC5755 Ac-RYYRWK-NH2
- BCC5736 Ac-RYYRIK-NH2
- BCC6723 4-PPBP maleate
- BCC6743 3-AQC
- BCC1724 LY341495 LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.
- BCC6882 Spiperone hydrochloride
- BCC6944 AM 281 Potent, selective CB1 antagonist/inverse agonist
- BCC7512 Ro 04-6790
- BCC5766 Orexin B (mouse) Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
- BCC1595 glucagon receptor antagonists 3 Glucagon receptor antagonists-3 is a highly potent glucagon receptor antagonist.
- BCC1594 glucagon receptor antagonists 2 Glucagon receptor antagonists-2 is a highly potent glucagon receptor antagonist.
- BCC7785 NF 340
- BCC7426 PD 176252 PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
- BCC1982 Talnetant hydrochloride Talnetant Hcl(SB 223412 Hcl) is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.
- BCC7311 2'-MeCCPA
- BCC5764 Orexin A (human, rat, mouse) Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A human, rat, mouse has a role in the regulation of feeding behavior. Orexin A human, rat, mouse is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
- BCC5765 Orexin B (human) Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
- BCC6832 BD 1063 dihydrochloride BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
- BCC6684 MR 16728 hydrochloride
- BCC5657 L-693,403 maleate
- BCC5673 SB 203186 hydrochloride
- BCC5819 HS 014
- BCC5703 Nocistatin (bovine)
- BCC7364 (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
- BCC1674 JWH 073
- BCC6006 CART (55-102) (rat)
- BCC7718 Org 12962 hydrochloride
- BCC6008 CART (62-76) (rat, human)
- BCC5936 SB 265610 SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC50s of 3.7 nM and 70 nM, respectively.
- BCC6650 m-Chlorophenylbiguanide hydrochloride
- BCC5820 HS 024
- BCC5732 Nocistatin (human)
- BCC6291 Org 37684
- BCC5701 [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
- BCC6007 CART (55-102) (human)
- BCC6858 WB 4101 hydrochloride
- BCC5959 Apelin-17 (human, bovine)
- BCC7358 [Pyr1]-Apelin-13 [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.
- BCC7916 SB 268262
- BCC7423 (±)-J 113397 Potent and selective NOP antagonist
- BCC7220 L-803,087 trifluoroacetate L-803087 is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM, which is > 280-fold higher than other somatostatin receptors. L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice.
- BCC7221 L-817,818
- BCC6029 BX 471 BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
- BCC1777 MPEP Hydrochloride MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
- BCC6973 DH 97
- BCC5868 Antisauvagine-30
- BCC7480 Antalarmin hydrochloride
- BCC5891 GLP-2 (human) GLP-2(1-33) (human) is an enteroendocrine hormone which can bind to the GLP-2 receptor and stimulate the growth of intestinal epithelium.
- BCC3814 Mirabegron (YM178) Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
- BCC1483 Cinacalcet Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
- BCC5992 R 892
- BCC7011 Abn-CBD
- BCC5911 Apelin-36 (rat, mouse)
- BCC4320 Terbutaline Sulfate Terbutaline sulfate is a β2-adrenergic receptor agonist; a fast-acting bronchodilator and a tocolytic to delay premature labor.
- BCC4341 Xylazine HCl Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.
- BCC4333 Oxymetazoline HCl
- BCC4337 Ritodrine HCl Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.
- BCC4327 Guanabenz Acetate Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.
- BCC7289 2-Palmitoylglycerol
- BCC6094 MEN 11270
- BCC5781 [Arg14,Lys15]Nociceptin
- BCC5629 Methylprednisolone Sodium Succinate 6α-Methylprednisolone 21-hemisuccinate sodium salt is a glucocorticoid of slightly longer half-life than that of Prednisolone.
- BCC5897 Tabimorelin hemifumarate
- BCC1312 5-Iodotubercidin 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin.
- BCC7654 L-798,106 L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM at EP4, EP1 and EP2, respectively.
- BCC7475 L-748,337
- BCC6279 FSLLRY-NH2
- BCC6086 RWJ 52353
- BCC7991 TC-G 1000
- BCC7158 BIIE 0246 BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 of 15 nM.
- BCC5366 AL 8810
- BCC5552 Fimasartan Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure.
- BCC6657 Dihydroergocristine mesylate Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively.
- BCC6056 SB 328437
- BCC6813 Agmatine sulfate Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
- BCC4289 SB-334867 hydrochloride SB-334867 (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.
- BCC1362 Anamorelin Anamorelin is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
- BCC7177 NNC 63-0532
- BCC5796 Urotensin II (human) Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
- BCC7656 SLV 320 Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.
- BCC5910 Apelin-36 (human)
- BCC7433 RWJ 56110
- BCC6106 MRE 3008F20 MRE3008F20 is a highly potent and selective antagonist of adenosine A3 receptor (AA3R), inhibits agonist-induced cAMP elevation in resting T lymphocytes with an IC50 of 5 nM.
- BCC7924 Talsupram hydrochloride
- BCC7312 SEW 2871 SEW2871 is a highly selective, orally active S1P1 agonist with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood and has therapeutic implications in contexts of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.