TCS JNK 5aJNK2 and JNK3 inhibitor CAS# 312917-14-9 |
Related Products
- Calyculin A
Catalog No.:BCC2457
CAS No.:101932-71-2
- Calcineurin Autoinhibitory Peptide
Catalog No.:BCC2456
CAS No.:148067-21-4
- DL-AP3
Catalog No.:BCC2459
CAS No.:20263-06-3
- Ceramide
Catalog No.:BCC2458
CAS No.:3102-57-6
- Fostriecin sodium salt
Catalog No.:BCC2460
CAS No.:87860-39-7
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 312917-14-9 | SDF | Download SDF |
| PubChem ID | 766949 | Appearance | Powder |
| Formula | C20H16N2OS | M.Wt | 332.42 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | JNK Inhibitor IX; SC-202671 | ||
| Solubility | DMSO : ≥ 51 mg/mL (153.42 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide | ||
| SMILES | C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N | ||
| Standard InChIKey | WQGDQGAFSDMBLA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0). |
TCS JNK 5a Dilution Calculator
TCS JNK 5a Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0082 mL | 15.0412 mL | 30.0824 mL | 60.1649 mL | 75.2061 mL |
| 5 mM | 0.6016 mL | 3.0082 mL | 6.0165 mL | 12.033 mL | 15.0412 mL |
| 10 mM | 0.3008 mL | 1.5041 mL | 3.0082 mL | 6.0165 mL | 7.5206 mL |
| 50 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.2033 mL | 1.5041 mL |
| 100 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.6016 mL | 0.7521 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 7.5, respectively [1].
c-Jun N-terminal kinases (JNK) belong to the mitogen-activated protein kinase (MAPK) family. JNK1 and JNK2 are widely expressed, whereas JNK3 is mainly expressed in the brain and plays an important role to mediate neurodegeneration such as Alzheimer’s Disease and Parkinson’s Disease [1].
TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0 [1].
Reference:
[1]. Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett, 2007, 17(5): 1296-1301.
Featured Products
- Raucaffricine
Catalog No.:BCN4653
CAS No.:31282-07-2
- Hygromycin B
Catalog No.:BCC1204
CAS No.:31282-04-9
- Indacaterol
Catalog No.:BCC1650
CAS No.:312753-06-3
- gamma-Mangostin
Catalog No.:BCN5228
CAS No.:31271-07-5
- THIQ
Catalog No.:BCC7539
CAS No.:312637-48-2
- SKI II
Catalog No.:BCC5029
CAS No.:312636-16-1
- Tetrahydrocannabivarin
Catalog No.:BCN6935
CAS No.:31262-37-0
- IQ 3
Catalog No.:BCC8093
CAS No.:312538-03-7
- Cimigenol-3-one
Catalog No.:BCN7430
CAS No.:31222-32-9
- Eucalyptin
Catalog No.:BCN5227
CAS No.:3122-88-1
- Sideroxylin
Catalog No.:BCN5226
CAS No.:3122-87-0
- H-D-Ser-OH
Catalog No.:BCC2676
CAS No.:312-84-5
New Products
- LDN-27219
Catalog No.:BCC6236
CAS No.:312946-37-5
- Arjunic acid
Catalog No.:BCN5229
CAS No.:31298-06-3
- Estradiol Cypionate
Catalog No.:BCC4477
CAS No.:313-06-4
- Aristolochic acid A
Catalog No.:BCN6262
CAS No.:313-67-7
- ICA 121431
Catalog No.:BCC6358
CAS No.:313254-51-2
- Regadenoson
Catalog No.:BCC6438
CAS No.:313348-27-5
- Reversan
Catalog No.:BCC7764
CAS No.:313397-13-6
- VU 590 dihydrochloride
Catalog No.:BCC7803
CAS No.:313505-85-0
- T0070907
Catalog No.:BCC2261
CAS No.:313516-66-4
- INH1
Catalog No.:BCC6040
CAS No.:313553-47-8
- Bombesin
Catalog No.:BCC5708
CAS No.:31362-50-2
- PD 118057
Catalog No.:BCC7499
CAS No.:313674-97-4
TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
TCS JNK 5a,312917-14-9,JNK Inhibitor IX; SC-202671,Natural Products,JNK, buy TCS JNK 5a , TCS JNK 5a supplier , purchase TCS JNK 5a , TCS JNK 5a cost , TCS JNK 5a manufacturer , order TCS JNK 5a , high purity TCS JNK 5a
