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10Z-Hymenialdisine

10Z-Hymenialdisine

Catalog No. BCC5773
Size Price Stock
500µg $358.00 Ship Within 7 Days
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Quality Control of 10Z-Hymenialdisine

Chemical structure

10Z-Hymenialdisine

Biological Activity of 10Z-Hymenialdisine

Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48 μM respectively).

10Z-Hymenialdisine Dilution Calculator

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10Z-Hymenialdisine Molarity Calculator

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Chemical Properties of 10Z-Hymenialdisine

Cas No. 82005-12-7 SDF Download SDF
Synonyms SK&F 108752
Chemical Name (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
SMILES NC1=NC(=O)/C(N1)=C2/CCNC(=O)c3[nH]c(Br)cc23 NC1=NC(C(=O)N1)=C2/CCNC(=O)c3[nH]c(Br)cc23
Standard InChIKey ATBAETXFFCOZOY-QPJJXVBHSA-N
Standard InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4+
Formula C11H10BrN5O2 M.Wt 324.13
Solubility Soluble to 10 mM in DMSO
Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 10Z-Hymenialdisine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0852 mL 15.4259 mL 30.8518 mL 61.7036 mL 77.1295 mL
5 mM 0.617 mL 3.0852 mL 6.1704 mL 12.3407 mL 15.4259 mL
10 mM 0.3085 mL 1.5426 mL 3.0852 mL 6.1704 mL 7.713 mL
50 mM 0.0617 mL 0.3085 mL 0.617 mL 1.2341 mL 1.5426 mL
100 mM 0.0309 mL 0.1543 mL 0.3085 mL 0.617 mL 0.7713 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Kewords:

10Z-Hymenialdisine,82005-12-7,SK&F 108752,MAPK Signaling,MEK1/2, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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