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Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for Protein Ser/Thr Phosphatases

  1. Cat.No. Product Name Information
  2. BCC2456 Calcineurin Autoinhibitory PeptideSelective calcineurin inhibitor
  3. BCC2457 Calyculin AProtein phosphatase 1 and 2A inhibitor
  4. BCC2458 CeramideSer/Thr protein phosphatase activator
  5. BCC2459 DL-AP3Phosphoserine phosphatase inhibitor
  6. BCC2460 Fostriecin sodium saltPotent PP2A and PP4 inhibitor
  7. BCC2461 Fumonisin B1Inhibitor of Ser/Thr phosphatase. Also inhibits sphingosine N-acyltransferase
  8. BCC2462 INCA-6Inhibitor of calcineurin-substrate association
  9. BCC2463 NFAT InhibitorInhibitor of calcineurin-mediated NFAT activation
  10. BCC2464 Okadaic acidProtein phosphatase 1 and 2A inhibitor
  11. BCC2465 Sal 003Cellular phosphatase complex inhibitor
  12. BCC2466 Alexidine dihydrochlorideSelective inhibitor of PTPMT1; maintains functional HSCs ex vivo
  13. BCC2467 BVT 948Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling
  14. BCC2468 NSC 87877Potent inhibitor of shp2 and shp1 PTP
  15. BCC2469 TCS 401Selective PTP1B inhibitor
  16. BCC3636 CID 2011756Pan protein kinase D (PKD) inhibitor; cell permeable
  17. BCC3980 Sephin1Selective PPP1R15A inhibitor
  18. BCC4187 Nafamostat
  19. BCC4188 Nafamostat hydrochloride
  20. BCC5147 CCT007093PPM1D inhibitor
  21. BCC5506 PTP1B-IN-1
  22. BCC5532 LB-100
  23. BCC6481 Sanguinarine chlorideInhibitor of protein phosphatase 2C (PP2C)
  24. BCC7109 NSC 95397Selective Cdc25 dual specificity phosphatase inhibitor
  25. BCC7199 NSC 663284Cdc25 phosphatase inhibitor; blocks cdk1 and cdk2 activation
  26. BCC7320 TautomycetinSelective PP1 inhibitor

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