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DNA Methyltransferase

DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.

Products for DNA Methyltransferase

  1. Cat.No. Product Name Information
  2. BCN2169 5-Aza-2'-deoxycytidine DNA methyltransferase inhibitor
  3. BCC1130 5-AzacytidineDNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes
  4. BCC1133 LomeguatribMGMT inhibitor
  5. BCC1134 RG 108Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation
  6. BCC1136 ZebularineDNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs
  7. BCC2221 SGI-110DNA methyltransferases inhibitor,potent
  8. BCC3611 Nanaomycin ADNMT3B inhibitor
  9. BCC4016 Nanaomycin C

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