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Histone Methyltransferase

Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).

Products for Histone Methyltransferase

  1. Cat.No. Product Name Information
  2. BCC1129 3-Deazaneplanocin,DZNepCell-permeable histone methyltransferase inhibitor
  3. BCC1131 BIX 01294G9a and GLP inhibitor
  4. BCC1135 UNC0638G9a/GLP HMTase inhibitor, potent and selective
  5. BCC2215 EPZ5676DOT1L inhibitor,potent and SAM competitive
  6. BCC2216 SGC 0946DOT1L inhibitor,highly potent and selective
  7. BCC2217 EntacaponeCOMT inhibitor
  8. BCC2218 EPZ004777Highly potent DOT1L inhibitor
  9. BCC2219 EPZ005687EZH2 inhibitor,potent and selective
  10. BCC2429 ChaetocinSUV39H1 Inhibitor
  11. BCC2430 UNC 0224Potent G9a and GLP inhibitor
  12. BCC2431 UNC 0646Potent and selective G9a and GLP inhibitor
  13. BCC3604 3-Deazaneplanocin A (DZNep) hydrochlorideSAHH and ENZ2 inhibitor
  14. BCC3634 EPZ-6438EZH2 inhibitor,potent and selective
  15. BCC4142 UNC0321G9a inhibitor
  16. BCC4143 UNC 0631G9a inhibitor
  17. BCC4264 AZ505SMYD2 inhibitor,potent and selective
  18. BCC4265 AZ505 ditrifluoroacetateSMYD2 inhibitor
  19. BCC4550 EPZ004777 HClDOT1L inhibitor,potent and selective
  20. BCC4551 MM-102MLL1 inhibitor,high-affinity peptidomimetic
  21. BCC4552 UNC1999Potent and selective EZH2/EZH1 inhibitor
  22. BCC4588 SGI-1027DNMT inhibitor
  23. BCC5561 PFI-2SETD7 methyltransferase inhibitor
  24. BCC5624 A 366Potent and selective G9a/GLP inhibitor
  25. BCC5625 UNC 2400Negative control of UNC 1999 (Cat. No. 4904)
  26. BCC5626 WDR5 0103WDR5 antagonist
  27. BCC5653 EPZ015666PRMT5 inhibitor
  28. BCC6443 C7280948Novel PRMT1 inhibitor
  29. BCC6543 SGC707PRMT3 inhibitor
  30. BCC8008 TC-E 5003Selective PRMT1 inhibitor
  31. BCC8013 C 21Selective PRMT1 inhibitor
  32. BCC8014 UNC 0642Potent and selective G9a and GLP inhibitor

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