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Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

CAS# 205370-59-8

Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

Catalog No. BCN6769----Order now to get a substantial discount!

Product Name & Size Price Stock
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 5mg $161 In Stock
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 10mg Please Inquire In Stock
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 20mg Please Inquire Please Inquire
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 50mg Please Inquire Please Inquire
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 100mg Please Inquire Please Inquire
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 200mg Please Inquire Please Inquire
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 500mg Please Inquire Please Inquire
Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose: 1000mg Please Inquire Please Inquire

Quality Control of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

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Chemical structure

Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

3D structure

Chemical Properties of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

Cas No. 205370-59-8 SDF Download SDF
PubChem ID 85263086 Appearance Powder
Formula C42H32O21 M.Wt 872.7
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES C1C(OC2=CC(=CC(=C2C1=O)O)OC3C(C(C4C(O3)COC(=O)C5=CC(=C(C(=C5C6=C(C(=C(C=C6C(=O)O4)O)O)O)O)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)C8=CC=CC=C8
Standard InChIKey HJEXOQUMFMERIM-UHFFFAOYSA-N
Standard InChI InChI=1S/C42H32O21/c43-19-8-16(9-26-30(19)20(44)12-25(60-26)14-4-2-1-3-5-14)59-42-36(54)38(63-39(55)15-6-21(45)31(49)22(46)7-15)37-27(61-42)13-58-40(56)17-10-23(47)32(50)34(52)28(17)29-18(41(57)62-37)11-24(48)33(51)35(29)53/h1-11,25,27,36-38,42-43,45-54H,12-13H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

The herbs of Lindera strychnifolia

Biological Activity of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

Description1. Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.

Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose Dilution Calculator

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Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose Molarity Calculator

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Preparing Stock Solutions of Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1459 mL 5.7293 mL 11.4587 mL 22.9174 mL 28.6467 mL
5 mM 0.2292 mL 1.1459 mL 2.2917 mL 4.5835 mL 5.7293 mL
10 mM 0.1146 mL 0.5729 mL 1.1459 mL 2.2917 mL 2.8647 mL
50 mM 0.0229 mL 0.1146 mL 0.2292 mL 0.4583 mL 0.5729 mL
100 mM 0.0115 mL 0.0573 mL 0.1146 mL 0.2292 mL 0.2865 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose

Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense.[Pubmed:25620384]

J Ethnopharmacol. 2015 Apr 2;163:256-63.

ETHNOPHARMACOLOGICAL RELEVANCE: Penthorum chinense Pursh has a long history of use as a health food and folk medicine to alleviate "heat"-associated disorders, promote circulation and diuresis, and to treat liver problems, and to protect the spleen. In this study we provide experimental evidence for the clinical use of Penthorum chinense in the treatment of diabetes mellitus. The aim of the study was to investigate the hypoglycemic effects of extracts and active constituents from Penthorum chinense. MATERIALS AND METHODS: High fat diet and STZ (35mg/kg) induced diabetic rats were administered with Penthorum chinense extract at graded oral doses (150 and 300mg/kg/day, ig.) for 2 weeks. A range of parameters, including blood glucose and lipid, serum insulin, glucose tolerance, were tested to evaluate its anti-hyperglycemic effects. Moreover, oral starch tolerance test (OSTT) was performed to test the level of postprandial glucose after administrating Penthorum chinense extract. In vitro study, the Penthorum chinense extracts and purified Penthorum chinense polyphenols were tested for alpha-amylase inhibitory activity. The polyphenols were determined by UPLC-Q-TOF mass spectrometry and NMR. RESULTS: The Penthorum chinense extract possessed anti-hyperglycemic activities as shown by the decreased serum levels of glycosylated hemoglobulin A1C (HbA1c), triglyceride(TG), total cholesterol (TC), and low density lipoprotein-cholesterol (LDL-C), as well as increased serum levels of high density lipoprotein-cholesterol (HDL-C) and insulin. Penthorum chinense extract also improved the oral glucose tolerance test (OGTT) to a certain degree. Moreover, the OSTT study showed that in diabetic rats, the extract (600mg/kg) caused a significant hypoglycemic effect with a blood glucose reduction of 42% at 60min. To identify the active constituents, three polyphenols, pinocembrin-7-O-[4'',6''-hexahydroxydiphenoyl]-beta-d-glucose (1), pinocembrin-7-O-[3''-O-galloyl-4'', 6''-hexahydroxydiphenoyl]-beta- d-glucose (2), and thonningianin A (3) were isolated from Penthorum chinense. Compounds 1-3 moderately inhibited alpha-amylase activity, with IC50 values of 0.14, 0.03, and 0.08micromol/ml, respectively. CONCLUSIONS: The folk medicinal plant, Penthorum chinense produced a moderated anti-hyperglycemic effect on STZ-induced diabetic rats and starch induced postprandial hyperglycemic mice.

Description

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a flavanone compound.

Keywords:

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