FaradiolCAS# 20554-95-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 20554-95-4 | SDF | Download SDF |
| PubChem ID | 122856 | Appearance | White powder |
| Formula | C30H50O2 | M.Wt | 442.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | 16β-Hydroxypseudotaraxasterol | ||
| Solubility | Soluble in chloroform; insoluble in water | ||
| Chemical Name | (3S,4aR,6aR,6aR,6bR,8S,8aS,12S,12aS,14bR)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,6a,7,8,9,12,12a,13,14,14a-tetradecahydro-1H-picene-3,8-diol | ||
| SMILES | CC1C2C3CCC4C5(CCC(C(C5CCC4(C3(CC(C2(CC=C1C)C)O)C)C)(C)C)O)C | ||
| Standard InChIKey | BNHIQKVOPNHQKO-MIISSIQISA-N | ||
| Standard InChI | InChI=1S/C30H50O2/c1-18-11-14-28(6)24(32)17-30(8)20(25(28)19(18)2)9-10-22-27(5)15-13-23(31)26(3,4)21(27)12-16-29(22,30)7/h11,19-25,31-32H,9-10,12-17H2,1-8H3/t19-,20-,21+,22?,23+,24+,25+,27+,28-,29-,30-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Faradiol shows inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- induced inflammation in mice; it can inhibit markedly the tumor-promoting effect of TPA (1 ug/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[α] anthracene (50 ug/mouse). 2. Faradiol shows inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter. |
Faradiol Dilution Calculator
Faradiol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2589 mL | 11.2943 mL | 22.5887 mL | 45.1773 mL | 56.4717 mL |
| 5 mM | 0.4518 mL | 2.2589 mL | 4.5177 mL | 9.0355 mL | 11.2943 mL |
| 10 mM | 0.2259 mL | 1.1294 mL | 2.2589 mL | 4.5177 mL | 5.6472 mL |
| 50 mM | 0.0452 mL | 0.2259 mL | 0.4518 mL | 0.9035 mL | 1.1294 mL |
| 100 mM | 0.0226 mL | 0.1129 mL | 0.2259 mL | 0.4518 mL | 0.5647 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Parthenolide
Catalog No.:BCN4896
CAS No.:20554-84-1
- 2'',4''-Di-O-(Z-p-coumaroyl)afzelin
Catalog No.:BCN4676
CAS No.:205534-17-4
- Fenfangjine G
Catalog No.:BCN3297
CAS No.:205533-81-9
- Fmoc-D-Phe(4-I)-OH
Catalog No.:BCC3262
CAS No.:205526-29-0
- Fmoc-D-Phe(3-Cl)-OH
Catalog No.:BCC3170
CAS No.:205526-23-4
- Rauvovertine A
Catalog No.:BCN7728
CAS No.:2055073-75-9
- Rauvovertine C
Catalog No.:BCN7727
CAS No.:2055073-74-8
- Rauvovertine B
Catalog No.:BCN7726
CAS No.:2055073-72-6
- Paederoside
Catalog No.:BCN3437
CAS No.:20547-45-9
- Taxezopidine G
Catalog No.:BCN6947
CAS No.:205440-22-8
- BU 224 hydrochloride
Catalog No.:BCC6765
CAS No.:205437-64-5
- Pinocembrin 7-O-(3'-galloyl-4',6'-(S)-hexahydroxydiphenoyl)-beta-D-glucose
Catalog No.:BCN6769
CAS No.:205370-59-8
- Pterocarpadiol B
Catalog No.:BCN7757
CAS No.:2055882-20-5
- Pterocarpadiol A
Catalog No.:BCN7758
CAS No.:2055882-21-6
- Pterocarpadiol C
Catalog No.:BCN7759
CAS No.:2055882-22-7
- Pterocarpadiol D
Catalog No.:BCN7760
CAS No.:2055882-23-8
- Oxibendazole
Catalog No.:BCC4818
CAS No.:20559-55-1
- alpha-Solanine
Catalog No.:BCN2701
CAS No.:20562-02-1
- alpha-Chaconine
Catalog No.:BCN2162
CAS No.:20562-03-2
- Orexin A (human, rat, mouse)
Catalog No.:BCC5764
CAS No.:205640-90-0
- Orexin B (human)
Catalog No.:BCC5765
CAS No.:205640-91-1
- SB273005
Catalog No.:BCC6501
CAS No.:205678-31-5
- Calycosin
Catalog No.:BCN5930
CAS No.:20575-57-9
- Oxytetracycline hydrochloride
Catalog No.:BCC9110
CAS No.:2058-46-0
Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.[Pubmed:11809525]
Cancer Lett. 2002 Mar 8;177(1):7-12.
Fifteen pentacyclic triterpene diols and triols, consisting of: six taraxastanes, Faradiol (1), heliantriol B0 (2), heliantriol C (3), 22alpha-methoxyFaradiol (4), arnidiol (5), and Faradiol alpha-epoxide (6); five oleananes, maniladiol (7), erythrodiol (8), longispinogenin (9), coflodiol (10), and heliantriol A(1) (11); two ursanes, brein (12) and uvaol (13); and two lupanes, calenduladiol (14) and heliantriol B2 (15), isolated from the non-saponifiable lipid fraction of the edible flower extract of chrysanthemum (Chrysanthemum morifolium) were evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, in Raji cells as a primary screening test for anti-tumor-promoters. All of the compounds tested showed inhibitory effects against EBV-EA activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter. Evaluation of the cytotoxic activity of six compounds, 1-3 and 5-7, against human cancer cell lines revealed that compound 5 possesses a wide range of cytotoxicity, with GI50 values (concentration that yields 50% growth) of mostly less than 6 microM.
Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.[Pubmed:8692541]
Oncology. 1996 Jul-Aug;53(4):341-4.
Two taraxastane-type hydroxy triterpenes, taraxasterol and Faradiol, isolated from the flowers of Compositae plants Cynara scolymus (artichoke) and Chrysanthemum morifilolium (chrysanthemum), respectively, showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. At 2.0 mumol/mouse, these compounds inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[alpha]anthracene (50 micrograms/mouse).
