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3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

CAS# 204935-85-3

3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

Catalog No. BCN1503----Order now to get a substantial discount!

Product Name & Size Price Stock
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 5mg $265 In Stock
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 10mg Please Inquire In Stock
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 20mg Please Inquire Please Inquire
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 50mg Please Inquire Please Inquire
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 100mg Please Inquire Please Inquire
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 200mg Please Inquire Please Inquire
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 500mg Please Inquire Please Inquire
3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone: 1000mg Please Inquire Please Inquire

Quality Control of 3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

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Chemical structure

3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

3D structure

Chemical Properties of 3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

Cas No. 204935-85-3 SDF Download SDF
PubChem ID 122169315 Appearance Powder
Formula C21H22O6 M.Wt 370.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R)-3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
SMILES CC(=CCC1=C(C=C(C2=C1OC(C(C2=O)O)C3=CC=C(C=C3)O)OC)O)C
Standard InChIKey CTUJEHJOZXGIIE-VQTJNVASSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

The seeds of Cassia obtusifolia L.

3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone Dilution Calculator

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3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone Molarity Calculator

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Preparing Stock Solutions of 3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6998 mL 13.4989 mL 26.9978 mL 53.9957 mL 67.4946 mL
5 mM 0.54 mL 2.6998 mL 5.3996 mL 10.7991 mL 13.4989 mL
10 mM 0.27 mL 1.3499 mL 2.6998 mL 5.3996 mL 6.7495 mL
50 mM 0.054 mL 0.27 mL 0.54 mL 1.0799 mL 1.3499 mL
100 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.6749 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexah ydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methano ne (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.[Pubmed:28368581]

J Med Chem. 2017 Apr 27;60(8):3405-3421.

The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing's syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted side effects in some patients. Optimization of the previously described fused azadecalin series of selective GR antagonists led to the identification of CORT125134, which is currently being evaluated in a phase 2 clinical study in patients with Cushing's syndrome.

Synthesis, Cytotoxic and Anti-proliferative Activity of Novel Thiophene, Thieno[2,3-b]pyridine and Pyran Derivatives Derived from 4,5,6,7-tetrahydrobenzo[b]thiophene Derivative.[Pubmed:28380235]

Acta Chim Slov. 2017 Mac;64(1):117-128.

Novel tetrahydrobenzo[b]thienopyrole derivatives are synthesized from 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene (1) through its reaction with alpha-chloroacetone to give the corresponding N-alkyl derivative 3. Compound 3 undergoes ready cyclization in sodium ethoxide solution to give the tetrahydrobenzo[b]thienopyrrole 4. The latter compound 4 is used as the key starting material for the synthesis of thiophene, thieno[2,3-b]pyridine and pyran derivatives. The cytotoxicity of the synthesized products towards the human cancer cell lines namely gastric cancer (NUGC), colon cancer (DLD-1), liver cancer (HA22T and HEPG-2), breast cancer (MCF-7), nasopharyngeal carcinoma (HONE-1) and normal fibroblast (WI-38) cell lines are measured. Compounds 4, 7a, 7b, 8a, 8b, 10c, 10d, 10f, 12a, 12b, 14b and 15b exhibit the optimal cytotoxic effect against cancer cell lines. Compounds 7b and 14b show the maximum inhibitory effect and these are much higher than the reference CHS-828 (pyridyl cyanoguanidine). On the other hand, the anti-proliferative evaluations of these compounds with high potency against the cancer cell lines L1210, Molt4/C8, CEM, K562, K562/4 and HCT116 show that compounds 7b and 8b give IC50's against Molt4/C8 and CEM cell lines higher than that of the reference, doxorubicin.

Synthesis, Structure, and Properties of Clathrate Si30.3(8) P15.7(8) Se7.930(3).[Pubmed:28378371]

Chemistry. 2017 Jul 18;23(40):9505-9516.

The new clathrate single crystal Si30.3(8) P15.7(8) Se7.930(3) was synthesized through a solid-state reaction, and it was characterized to have a unit cell parameter a=19.7614(1) A and belong to space group Fm3 . In this clathrate structure, a Se1-Si3 bond forms in place of the tetrakaidecahedron structure, and pental dodecahedral cages composed of Si and P atoms encapsulate Se2, Se3, and Se4 guest atoms. Similar structures are observed in partial Te- and Ge-substituted compounds. Theoretical calculations based on an ordered formula Si32 P14 Se7 showed a semiconducting electronic structure with a band gap of 0.711 eV. A photoelectric response was observed in this compound at room temperature. Across the whole temperature range, this material exhibited a weak temperature-dependent diamagnetic signal, and no phase transition or thermal anomaly was observed in heat capacity measurements.

Structure and Gene Cluster of the K93 Capsular Polysaccharide of Acinetobacter baumannii B11911 Containing 5-N-Acetyl-7-N-[(R)-3-hydroxybutanoyl]pseudaminic Acid.[Pubmed:28371606]

Biochemistry (Mosc). 2017 Apr;82(4):483-489.

Capsular polysaccharide (CPS) assigned to the K93 type was isolated from the bacterium Acinetobacter baumannii B11911 and studied by sugar analysis along with one- and two-dimensional (1)H and (13)C NMR spectroscopy. The CPS was found to contain a derivative of pseudaminic acid, and the structure of the branched tetrasaccharide repeating unit was established. Genes in the KL93 capsule biosynthesis locus were annotated and found to be consistent with the CPS structure established. The K93 CPS has the alpha-d-Galp-(1-->6)-beta-d-Galp-(1-->3)-d-GalpNAc trisaccharide fragment in common with the K14 CPS of Acinetobacter nosocomialis LUH 5541 and A. baumannii D46. It also shares the beta-d-Galp-(1-->3)-d-GalpNAc disaccharide fragment and the corresponding predicted Gal transferase Gtr5, as well as the initiating GalNAc-1-P transferase ItrA2, with a number of A. baumannii strains.

Description

(2R,3R)-3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone can be used in a flame retardant for transparent polycarbonate products or in elevator illumination devices research.

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