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Catalog No. BCC6602
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10mg $292.00 Ship Within 7 Days
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Quality Control of (R)-4-Carboxyphenylglycine

Chemical structure


Biological Activity of (R)-4-Carboxyphenylglycine

Moderately potent NMDA receptor antagonist. (RS)-4-Carboxyphenylglycine and (S)-4-Carboxyphenylglycine also available.

(R)-4-Carboxyphenylglycine Dilution Calculator

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(R)-4-Carboxyphenylglycine Molarity Calculator



Chemical Properties of (R)-4-Carboxyphenylglycine

Cas No. 134052-68-9 SDF Download SDF
Synonyms (R)-4CPG
Formula C9H9NO4 M.Wt 195.17
Solubility Soluble to 100 mM in 1eq. NaOH and to 5 mM in water
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (R)-4-Carboxyphenylglycine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.1237 mL 25.6187 mL 51.2374 mL 102.4748 mL 128.0935 mL
5 mM 1.0247 mL 5.1237 mL 10.2475 mL 20.495 mL 25.6187 mL
10 mM 0.5124 mL 2.5619 mL 5.1237 mL 10.2475 mL 12.8093 mL
50 mM 0.1025 mL 0.5124 mL 1.0247 mL 2.0495 mL 2.5619 mL
100 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.0247 mL 1.2809 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (R)-4-Carboxyphenylglycine

(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo.[Pubmed: 9423922]

The effects of the metabotropic glutamate receptor antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) on the induction of long-term potentiation (LTP) in the dentate gyrus were examined under urethane anaesthesia in vivo. In experiment 1, bilateral intraventricular infusion of either 20 mM or 200 mM (R,S)-MCPG (5 microl each side) failed to block LTP in the perforant path-granule cell projection, relative to vehicle-infused controls; 30 mM D-AP5 (5 microl each side) infused in the same way as MCPG completely blocked LTP. Experiment 2, in which the contralateral perforant path-dentate gyrus pathway was used as a non-tetanized control, revealed that slight baseline changes induced by MCPG infusion were transient; again no block of LTP was obtained. The efficacy of mGluR blockade was confirmed in experiment 3, in which MCPG antagonized an increase in spontaneous activity induced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD). In experiment 4, significant depotentiation was induced by low frequency stimulation (5 Hz for 1 min) given 2 min after high frequency tetanization, but MCPG remained ineffective in blocking LTP after a second tetanus. In experiment 5, increasing the period of low frequency stimulation from 1 to 10 min produced greater depotentiation, but still did not unmask an MCPG-sensitive component of LTP. These experiments fail to support a role for mGluRs in the induction of LTP in the dentate gyrus under urethane anaesthesia in vivo, nor do they support the idea that a metabotropic switch controlling sensitivity to MCPG is reset by depotentiation.

(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) blocks spatial learning in rats and long-term potentiation in the dentate gyrus in vivo.[Pubmed: 8177513]

Recently, it was demonstrated by the use of the competitive and selective antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) that metabotropic glutamate receptor (mGluR) activation is required to induce long-term potentiation (LTP) in the hippocampus. Accordingly, we investigated whether MCPG also inhibits spatial learning. Rats were trained on a spatial alternation task in a Y-maze with footshock reinforcement, and MCPG (0.0208 mg) was injected intracerebroventricularly prior to training and/or retention test. Animals injected pre-training are clearly impaired in retention, whereas preretention application was without effect. A state dependency could be excluded. Additionally, MCPG at the same concentration completely blocks a potentiation at perforant path/dentate gyrus synapses in vivo. These results strongly implicate a role of mGluRs in spatial learning and LTP.


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