IKKε-IN-1CAS# 1292310-49-6 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1292310-49-6 | SDF | Download SDF |
| PubChem ID | 51049969 | Appearance | Powder |
| Formula | C26H27N5O3 | M.Wt | 457.52 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 21.5 mg/mL (46.99 mM; Need ultrasonic and warming) | ||
| Chemical Name | 5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrile | ||
| SMILES | C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5)C#N | ||
| Standard InChIKey | BWABTWGSXHTHCG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C26H27N5O3/c27-18-20-17-19(1-6-25(20)34-23-8-13-32-14-9-23)24-7-10-28-26(30-24)29-21-2-4-22(5-3-21)31-11-15-33-16-12-31/h1-7,10,17,23H,8-9,11-16H2,(H,28,29,30) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
IKKε-IN-1 Dilution Calculator
IKKε-IN-1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1857 mL | 10.9285 mL | 21.857 mL | 43.7139 mL | 54.6424 mL |
| 5 mM | 0.4371 mL | 2.1857 mL | 4.3714 mL | 8.7428 mL | 10.9285 mL |
| 10 mM | 0.2186 mL | 1.0928 mL | 2.1857 mL | 4.3714 mL | 5.4642 mL |
| 50 mM | 0.0437 mL | 0.2186 mL | 0.4371 mL | 0.8743 mL | 1.0928 mL |
| 100 mM | 0.0219 mL | 0.1093 mL | 0.2186 mL | 0.4371 mL | 0.5464 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
In Vitro:TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].
References:
[1]. Muvaffak A, et al. Evaluating TBK1 as a therapeutic target in cancers with activated IRF3. Mol Cancer Res. 2014 Jul;12(7):1055-66.
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TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
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