VAL-083Bi-functional alkylating agent CAS# 23261-20-3 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 23261-20-3 | SDF | Download SDF |
| PubChem ID | 31789 | Appearance | Powder |
| Formula | C6H10O4 | M.Wt | 146.14 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Dianhydrodulcitol; Dianhydrogalactitol | ||
| Solubility | DMF : ≥ 100 mg/mL (684.28 mM) H2O : 50 mg/mL (342.14 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 1,2-bis(oxiran-2-yl)ethane-1,2-diol | ||
| SMILES | C1C(O1)C(C(C2CO2)O)O | ||
| Standard InChIKey | AAFJXZWCNVJTMK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | VAL-083 is a structurally unique first-in-class N7-bifunctional alkylating agent of DNA. | |||||
| Targets | DNA | |||||
VAL-083 Dilution Calculator
VAL-083 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | 136.8551 mL | 171.0688 mL |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | 27.371 mL | 34.2138 mL |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL | 13.6855 mL | 17.1069 mL |
| 50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 2.7371 mL | 3.4214 mL |
| 100 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.3686 mL | 1.7107 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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VAL-083 is a bi-functional alkylating agent, with potential antitumor activity.
VAL-083 can cross the blood brain barrier and appears to be selective for tumor cells. VAL-083 alkylates and crosslinks DNA which ultimately inhibit the proliferation of cancer cells. VAL-083 does not show cross-resistance to other conventional chemotherapeutic agents. The half-life of VAL-083 in the brain is long. VAL-083 has been assessed in multiple studies as chemotherapy in the treatment of newly diagnosed and recurrent brain tumors.
Reference:
http://www. delmarpharma.com/product_development_programs/val083/
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VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
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