WAY 267464 dihydrochloridePotent non-peptide oxytocin receptor agonist CAS# 1432043-31-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1432043-31-6 | SDF | Download SDF |
| PubChem ID | 71555165 | Appearance | Powder |
| Formula | C32H35N7O4.2HCl | M.Wt | 654.59 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 80 mM in DMSO and to 5 mM in water | ||
| Chemical Name | 4-[(3,5-dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-2,4-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide;dihydrochloride | ||
| SMILES | CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O.Cl.Cl | ||
| Standard InChIKey | OFWMUAWQQXSNJI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C32H35N7O4.2ClH/c1-21-13-23(31(42)39-20-25-18-34-36(2)30(25)35-28-5-3-4-6-29(28)39)7-8-24(21)17-33-32(43)38-11-9-37(10-12-38)19-22-14-26(40)16-27(41)15-22;;/h3-8,13-16,18,34,40-41H,9-12,17,19-20H2,1-2H3,(H,33,43);2*1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia. |
WAY 267464 dihydrochloride Dilution Calculator
WAY 267464 dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5277 mL | 7.6384 mL | 15.2767 mL | 30.5535 mL | 38.1918 mL |
| 5 mM | 0.3055 mL | 1.5277 mL | 3.0553 mL | 6.1107 mL | 7.6384 mL |
| 10 mM | 0.1528 mL | 0.7638 mL | 1.5277 mL | 3.0553 mL | 3.8192 mL |
| 50 mM | 0.0306 mL | 0.1528 mL | 0.3055 mL | 0.6111 mL | 0.7638 mL |
| 100 mM | 0.0153 mL | 0.0764 mL | 0.1528 mL | 0.3055 mL | 0.3819 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 3'-O-Galloylmyricitrin
Catalog No.:BCN8268
CAS No.:143202-36-2
- K02288
Catalog No.:BCC5084
CAS No.:1431985-92-0
- WEHI-539
Catalog No.:BCC2055
CAS No.:1431866-33-9
- (S)-Tedizolid
Catalog No.:BCC1294
CAS No.:1431699-67-0
- KN-92 hydrochloride
Catalog No.:BCC1681
CAS No.:1431698-47-3
- CCT241533 hydrochloride
Catalog No.:BCC1463
CAS No.:1431697-96-9
- SB-408124 Hydrochloride
Catalog No.:BCC1929
CAS No.:1431697-90-3
- OTSSP167
Catalog No.:BCC4314
CAS No.:1431697-89-0
- AT7867 dihydrochloride
Catalog No.:BCC1378
CAS No.:1431697-86-7
- AT7519 trifluoroacetate
Catalog No.:BCC1377
CAS No.:1431697-85-6
- gamma-secretase modulator 3
Catalog No.:BCC1585
CAS No.:1431697-84-5
- CAL-130 Hydrochloride
Catalog No.:BCC1441
CAS No.:1431697-78-7
- Nyasicol 1,2-acetonide
Catalog No.:BCN6879
CAS No.:1432057-64-1
- Catalponol methylthiomethyl ether
Catalog No.:BCC8905
CAS No.:1432057-74-3
- 10-Acetoxyscandine
Catalog No.:BCN7035
CAS No.:1432058-90-6
- 3-(3-Hydroxy-3-methylbutanyl)-2,4,6-trihydroxybenzophenone
Catalog No.:BCC8588
CAS No.:1432062-53-7
- 8-Isomulberrin hydrate
Catalog No.:BCC8789
CAS No.:1432063-35-8
- 6-O-Acetylcoriatin
Catalog No.:BCN7048
CAS No.:1432063-63-2
- 10-O-Acetylisocalamendiol
Catalog No.:BCN7071
CAS No.:1432064-69-1
- (Z)-3-Hydroxy-5-methoxystilbene
Catalog No.:BCN6688
CAS No.:143207-76-5
- 7-Geranyloxy-5-methoxycoumarin
Catalog No.:BCN5806
CAS No.:1432075-68-7
- Dehydroadynerigenin beta-neritrioside
Catalog No.:BCN4706
CAS No.:143212-60-6
- Z-2-Nal-OH
Catalog No.:BCC3291
CAS No.:143218-10-4
- (-)-Lyoniresinol 9'-O-glucoside
Catalog No.:BCN7037
CAS No.:143236-02-6
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist.[Pubmed:19615387]
Neuropharmacology. 2010 Jan;58(1):69-77.
The widely reported effects of oxytocin (OT) on CNS function has generated considerable interest in the therapeutic potential for targeting this system for a variety of human psychiatric diseases, including anxiety disorders, autism, schizophrenia, and depression. The utility of synthetic OT, as both a research tool and neurotherapeutic, is limited by the physiochemical properties inherent in most neuropeptides, notably its short half-life and poor blood brain barrier penetration. Subsequently, the discovery and development of non-peptide molecules that act as selective agonists of the oxytocin receptor (OTR) has been an important goal of the field. In this study, we report the receptor and behavioral pharmacology of WAY-267464, a first generation small-molecule OTR agonist. WAY-267464 is a high-affinity, potent, and selective (vs. V1a, V2, V1b) agonist of the OTR. In assays measuring both behavioral (four-plate test, elevated zero maze) and autonomic (stress-induced hyperthermia) parameters of the anxiety response, WAY-267464 exhibits an anxiolytic-like profile similar to OT. We have demonstrated that the anxiolytic-like profile of WAY-267464 is mediated through central sites of action. WAY-267464 also significantly reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine, similar to the antipsychotic-like effects previously reported for OT. Interestingly, in the mouse tail suspension test, WAY-267464 failed to produce changes in immobility that are seen with OT, raising the question of whether the antidepressant-like activity of OT may be working independently of the OTR. A selective OTR antagonist also failed to block the effects of OT on immobility in the TST. The significance of these findings for shaping the clinical development of OTR agonists is discussed.
