ThujaplicatinCAS# 6512-66-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 6512-66-9 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C20H22O7 | M.Wt | 374.42 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Thujaplicatin Dilution Calculator
Thujaplicatin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6708 mL | 13.354 mL | 26.708 mL | 53.416 mL | 66.7699 mL |
| 5 mM | 0.5342 mL | 2.6708 mL | 5.3416 mL | 10.6832 mL | 13.354 mL |
| 10 mM | 0.2671 mL | 1.3354 mL | 2.6708 mL | 5.3416 mL | 6.677 mL |
| 50 mM | 0.0534 mL | 0.2671 mL | 0.5342 mL | 1.0683 mL | 1.3354 mL |
| 100 mM | 0.0267 mL | 0.1335 mL | 0.2671 mL | 0.5342 mL | 0.6677 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic activity of Ipomoea cairica.[Pubmed:18569716]
Nat Prod Res. 2008 Jun 15;22(9):747-53.
(+)-(8R,8'S)-Thujaplicatin methyl ether (1), arctigenin (2), matairesinol (3), trans-2,3-dibenzylbutyrolactone (4), vanillic acid (5), p-hydroxybenzoic acid (6), methoxybenzoic acid (7), methylparaben (8), stearic acid (9), palmitic acid (10), olenic acid (11), friedelinol (12), and a mixture of beta-sitosterol (13) and stigmasterol (14) were obtained from the methanolic extract of the Ipomoea cairica (L.) Sweet (Convolvulaceae). The structure of compound 1 was established by spectroscopic analyses. Among them, 2 and 4 were demonstrated to have significant cytotoxicity against LNCaP cell line. Compound 4 was also found to be significantly active against A549 cell line.
Analysis of western redcedar (Thuja plicata Donn) heartwood components by HPLC as a possible screening tool for trees with enhanced natural durability.[Pubmed:17555638]
J Chromatogr Sci. 2007 May-Jun;45(5):281-5.
A method is described for the quantitative analysis of seven known compounds, specifically plicatic acid, Thujaplicatin methyl ether, beta-thujaplicin, gamma-thujaplicin, beta-thujaplicinol, thujic acid, and methyl thujate, in the ethanol extract of second growth western redcedar heartwood (Thuja plicata Donn) by high-performance liquid chromatography using diode array detection. The para bromo phenacyl ester of crotonic acid is synthesized for use as the internal standard for the method. Separation of compounds covering a wide range of polarities is achieved using an Inertsil ODS 3 3-micro column. Twenty seven second growth trees ranging in age from 40 to 125 years, originating from the coastal and interior regions of British Columbia, are selected for analysis and profiled using the described method. Samples consisting of five growth rings each are analyzed from the heartwood-sapwood boundary to the pith for each tree. Substantial variation in most heartwood compounds are detected within and between trees within a region. Significant variation in beta-thujaplicin, the ratio between gamma- and beta-thujaplicin, and methyl thujate is detected between coastal and interior populations.
Biosynthesis of yatein in Anthriscus sylvestris.[Pubmed:12956064]
Org Biomol Chem. 2003 Jul 21;1(14):2474-85.
Little is known about the biosynthesis of yatein, in spite of its importance as a typical heartwood lignan and a key biosynthetic intermediate of the antitumor lignan podophyllotoxin. The present study, based on individual administration of [13C]phenylalanine and deuterium labelled lignans and simultaneous administration of two distinct lignans labelled with deuterium atoms to Anthriscus sylvestris, established the two independent branch pathways from matairesinol, one to afford yatein via Thujaplicatin, 5-methylThujaplicatin, and 4,5-dimethylThujaplicatin and the other to bursehernin via pluviatolide. The latter pathway did not lead to yatein, eliminating the presence of a metabolic grid from matairesinol to yatein.
