PF9 tetrasodium saltPotent GPR17 agonist CAS# 851265-78-6 |
Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 851265-78-6 | SDF | Download SDF |
| PubChem ID | 90488909 | Appearance | Powder |
| Formula | C18H16N5Na4O13P3 | M.Wt | 695.23 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) | ||
| Chemical Name | tetrasodium;[[[(2R,3S,4R)-5-[6-amino-2-(2-phenylethynyl)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate | ||
| SMILES | C1=CC=C(C=C1)C#CC2=NC3=C(C(=N2)N)N=CN3C4C(C(C(O4)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O.[Na+].[Na+].[Na+].[Na+] | ||
| Standard InChIKey | ONTPGXYSNYMMOK-YEJXUIBNSA-J | ||
| Standard InChI | InChI=1S/C18H20N5O13P3.4Na/c19-16-13-17(22-12(21-16)7-6-10-4-2-1-3-5-10)23(9-20-13)18-15(25)14(24)11(34-18)8-33-38(29,30)36-39(31,32)35-37(26,27)28;;;;/h1-5,9,11,14-15,18,24-25H,8H2,(H,29,30)(H,31,32)(H2,19,21,22)(H2,26,27,28);;;;/q;4*+1/p-4/t11-,14-,15-,18?;;;;/m1..../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent agonist of GPR17 (EC50 = 36 pM). |
PF9 tetrasodium salt Dilution Calculator
PF9 tetrasodium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4384 mL | 7.1919 mL | 14.3837 mL | 28.7675 mL | 35.9593 mL |
| 5 mM | 0.2877 mL | 1.4384 mL | 2.8767 mL | 5.7535 mL | 7.1919 mL |
| 10 mM | 0.1438 mL | 0.7192 mL | 1.4384 mL | 2.8767 mL | 3.5959 mL |
| 50 mM | 0.0288 mL | 0.1438 mL | 0.2877 mL | 0.5753 mL | 0.7192 mL |
| 100 mM | 0.0144 mL | 0.0719 mL | 0.1438 mL | 0.2877 mL | 0.3596 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.[Pubmed:20394377]
J Med Chem. 2010 May 13;53(9):3489-501.
The application of frontal affinity chromatography-mass spectrometry (FAC-MS), along with molecular modeling studies, to the screening of potential drug candidates toward the recently deorphanized G-protein-coupled receptor (GPCR) GPR17 is shown. GPR17 is dually activated by uracil nucleotides and cysteinyl-leukotrienes, and is expressed in organs typically undergoing ischemic damage (i.e., brain, heart and kidney), thus representing a new pharmacological target for acute and chronic neurodegeneration. GPR17 was entrapped on an immobilized artificial membrane (IAM), and this stationary phase was used to screen a library of nucleotide derivatives by FAC-MS to select high affinity ligands. The chromatographic results have been validated with a reference functional assay ([(35)S]GTPgammaS binding assay). The receptor nucleotide-binding site was studied by setting up a column where a mutated GPR17 receptor (Arg255Ile) has been immobilized. The chromatographic behavior of the tested nucleotide derivatives together with in silico studies have been used to gain insights into the structure requirement of GPR17 ligands.
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