NorviburtinalCAS# 85051-41-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 85051-41-8 | SDF | Download SDF |
| PubChem ID | 390664 | Appearance | Yellow powder |
| Formula | C9H6O2 | M.Wt | 146.1 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | cyclopenta[c]pyran-7-carbaldehyde | ||
| SMILES | C1=COC=C2C1=CC=C2C=O | ||
| Standard InChIKey | VRMFZTBAWYVGGB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H6O2/c10-5-8-2-1-7-3-4-11-6-9(7)8/h1-6H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Norviburtinal possesses novel angiogenesis effect. 2. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines. 3. Norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity. |
Norviburtinal Dilution Calculator
Norviburtinal Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.8446 mL | 34.2231 mL | 68.4463 mL | 136.8925 mL | 171.1157 mL |
| 5 mM | 1.3689 mL | 6.8446 mL | 13.6893 mL | 27.3785 mL | 34.2231 mL |
| 10 mM | 0.6845 mL | 3.4223 mL | 6.8446 mL | 13.6893 mL | 17.1116 mL |
| 50 mM | 0.1369 mL | 0.6845 mL | 1.3689 mL | 2.7379 mL | 3.4223 mL |
| 100 mM | 0.0684 mL | 0.3422 mL | 0.6845 mL | 1.3689 mL | 1.7112 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bioassay-guided isolation of norviburtinal from the root of Rehmannia glutinosa, exhibited angiogenesis effect in zebrafish embryo model.[Pubmed:21843616]
J Ethnopharmacol. 2011 Oct 11;137(3):1323-7.
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Rehmannia glutinosa (RR) is commonly used as a wound-healing agent in various traditional Chinese herbal formulae; while angiogenesis is one of the crucial aspects in wound-healing. AIM OF THE STUDY: The objective of the present study was to investigate the angiogenesis effects of RR aqueous crude extract and its active component(s) using zebrafish model. MATERIALS AND METHODS: The in vivo angiogenesis effect was studied using transgenic TG(fli1:EGFP)(y1)/+(AB) zebrafish embryos by observing the capillary sprouts formation in sub-intestinal vessel (SIV) of zebrafish embryos after 72 h post-fertilization under fluorescence microscopy. RESULTS: Our results indicated that RR aqueous crude extract (250 mug/ml) exhibited significant angiogenesis effect, with an increase in capillary sprouts formation in SIV. Following sequential solvent partition of the RR aqueous crude extract with dichloromethane, ethyl acetate and n-butanol successively, the dichloromethane fraction (DCM) was found to have the most sprouts formation in the SIV region. Subjected to column chromatography, DCM fraction was further fractionated into six sub-fractions and among these tested, the sub-fraction C2 exhibited the most potent angiogenesis effect. The major component, C2A, was isolated and identified as Norviburtinal using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The compound Norviburtinal (at 50 mug/ml) was shown to possess significant angiogenesis effect in zebrafish model (p < 0.001). CONCLUSIONS: Norviburtinal was, for the first time, found in the extract of RR and possessed novel angiogenesis effect. Bioassay-guided fractionation suggested that Norviburtinal was not the only active component responsible for the angiogenesis effect of RR.
In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines.[Pubmed:11199138]
Planta Med. 2000 Dec;66(8):758-61.
Crude dichloromethane extracts of Kigelia pinnata stem bark and fruit showed cytotoxic activity in vitro against cultured melanoma and other cancer cell lines using the Sulphorhodamine B assay, which was used for bioassay-guided fractionation. Thin layer chromatography (TLC) examination of the most active fractions of both stem bark and fruits showed the presence of the same major components which were found to be Norviburtinal and beta-sitosterol. Norviburtinal was found to be the most active compound but had little selectivity for melanoma cell lines whilst isopinnatal also showed some cytotoxic activity. beta-Sitosterol was found to be comparatively inactive. HPLC analysis of the crude extract showed that the amount of Norviburtinal present in the plant material did not account for all of the activity of the total extracts.
