Neolitsine

CAS# 2466-42-4

Neolitsine

Catalog No. BCN4817----Order now to get a substantial discount!

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Neolitsine: 5mg $799 In Stock
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Quality Control of Neolitsine

Number of papers citing our products

Chemical structure

Neolitsine

3D structure

Chemical Properties of Neolitsine

Cas No. 2466-42-4 SDF Download SDF
PubChem ID 10064778 Appearance Powder
Formula C19H17NO4 M.Wt 323.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CCC2=CC3=C(C4=C2C1CC5=CC6=C(C=C54)OCO6)OCO3
Standard InChIKey GKEOKAJRKHTDOS-ZDUSSCGKSA-N
Standard InChI InChI=1S/C19H17NO4/c1-20-3-2-10-5-16-19(24-9-23-16)18-12-7-15-14(21-8-22-15)6-11(12)4-13(20)17(10)18/h5-7,13H,2-4,8-9H2,1H3/t13-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neolitsine

The leaves of Laurus nobilis

Biological Activity of Neolitsine

Description1. Neolitsine exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL. 2. Neolitsine and dicentrine have potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM.

Neolitsine Dilution Calculator

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Neolitsine Molarity Calculator

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Preparing Stock Solutions of Neolitsine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0921 mL 15.4607 mL 30.9215 mL 61.8429 mL 77.3036 mL
5 mM 0.6184 mL 3.0921 mL 6.1843 mL 12.3686 mL 15.4607 mL
10 mM 0.3092 mL 1.5461 mL 3.0921 mL 6.1843 mL 7.7304 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.2369 mL 1.5461 mL
100 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.6184 mL 0.773 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neolitsine

Anthelmintic activity of aporphine alkaloids from Cissampelos capensis.[Pubmed:17309014]

Planta Med. 2007 Mar;73(3):296-7.

Two known aporphine alkaloids, (S)-dicentrine (1) and (S)-Neolitsine (2), have been isolated from the MeOH extract of the aerial parts of Cissampelos capensis (Menispermaceae). The structures of these compounds were elucidated by NMR and MS analysis and comparison to literature data. These compounds were isolated by bioassay-guided fractionation using the Haemonchus contortus larval development assay. Compounds 1 and 2 exhibited EC90 values (concentration at which 90% loss of larval motility is observed) of 6.3 and 6.4 microg/mL, respectively. In an IN VIVO assay, administration of 1 resulted in 67% reduction of worm counts in mice at 25 mg/kg when dosed orally.

Vasorelaxing alkaloids and flavonoids from Cassytha filiformis.[Pubmed:18217715]

J Nat Prod. 2008 Feb;71(2):289-91.

Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid ( 3), cassythine ( 4), Neolitsine ( 7), and dicentrine ( 8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyaporphine ( 2), (-)- O-methylflavinatine ( 10), (-)-salutaridine ( 11), isohamnetin-3- O-beta-glucoside, and isohamnetin-3- O-rutinoside exerted moderate vessel-relaxing activities with IC 50 values from 16.50 to 32.81 microM at the test concentrations.

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