Lucidenic acid F

CAS# 98665-18-0

Lucidenic acid F

Catalog No. BCN6374----Order now to get a substantial discount!

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Quality Control of Lucidenic acid F

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Chemical structure

Lucidenic acid F

3D structure

Chemical Properties of Lucidenic acid F

Cas No. 98665-18-0 SDF Download SDF
PubChem ID 74028536 Appearance Powder
Formula C27H36O6 M.Wt 456.57
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(4,4,10,13,14-pentamethyl-3,7,11,15-tetraoxo-2,5,6,12,16,17-hexahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
SMILES CC(CCC(=O)O)C1CC(=O)C2(C1(CC(=O)C3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)C)C
Standard InChIKey GLUXWRYPXYKXKV-UHFFFAOYSA-N
Standard InChI InChI=1S/C27H36O6/c1-14(7-8-21(32)33)15-11-20(31)27(6)23-16(28)12-18-24(2,3)19(30)9-10-25(18,4)22(23)17(29)13-26(15,27)5/h14-15,18H,7-13H2,1-6H3,(H,32,33)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lucidenic acid F

The fruit body of Ganoderma lucidum

Biological Activity of Lucidenic acid F

DescriptionLucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction.
TargetsJNK | p38MAPK
In vitro

Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.[Pubmed: 14695801 ]

J Nat Prod. 2003 Dec;66(12):1582-5.

A new triterpene acid, lucidenic acid P (1a), and two new triterpene acid methyl esters, methyl lucidenates P (1b) and Q (2b), were isolated and characterized from the fruiting body of the fungus Ganoderma lucidum.
METHODS AND RESULTS:
Their structures were elucidated on the basis of spectroscopic methods. In addition, eight known triterpene acids, lucidenic acid A (3a), lucidenic acid C (4a), lucidenic acid D(2) (5a), lucidenic acid E(2) (6a), and Lucidenic acid F (7a) and ganoderic acid E (9a), lganoderic acid F (10a), and ganoderic acid T-Q (11a), and six known triterpene acid methyl esters, methyl lucidenates A (3b), D(2) (5b), E(2) (6b), F (7b), and L (8b) and methyl ganoderate F (10b), were isolated and identified from the fungus. All of the triterpenoids, with the exception of 7a, were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor promoters.
CONCLUSIONS:
All of the compounds tested showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 x 10(3) mol ratio/TPA).

Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.[Pubmed: 21453678 ]

Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24.

The Ganoderma lucidum (G. lucidum) is one of the oriental fungi that has been reported to have immunomodulatory properties. Although effect of β-glucans from G. lucidum has been well documented, little is known about how other major bioactive components, the triterpenes, contribute to the immunomodulatory function of G. lucidum.
METHODS AND RESULTS:
Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα production, while JNK inhibitor enhanced TNFα production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid-A, -F and -D(2), which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid A and Lucidenic acid F as modulators of JNK and p38, respectively.
CONCLUSIONS:
Thus, our data demonstrate that lucidenic acids-rich extract from G. lucidum AF enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.

Lucidenic acid F Dilution Calculator

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Lucidenic acid F Molarity Calculator

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Preparing Stock Solutions of Lucidenic acid F

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1902 mL 10.9512 mL 21.9024 mL 43.8049 mL 54.7561 mL
5 mM 0.438 mL 2.1902 mL 4.3805 mL 8.761 mL 10.9512 mL
10 mM 0.219 mL 1.0951 mL 2.1902 mL 4.3805 mL 5.4756 mL
50 mM 0.0438 mL 0.219 mL 0.438 mL 0.8761 mL 1.0951 mL
100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.438 mL 0.5476 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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