CarmineCAS# 1390-65-4 |
- Carminic acid
Catalog No.:BCN6541
CAS No.:1260-17-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1390-65-4 | SDF | Download SDF |
| PubChem ID | 14950 | Appearance | Red powder |
| Formula | C22H20O13 | M.Wt | 492.39 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]anthracene-2-carboxylic acid | ||
| SMILES | CC1=C2C(=CC(=C1C(=O)O)O)C(=O)C3=C(C2=O)C(=C(C(=C3O)O)C4C(C(C(C(O4)CO)O)O)O)O | ||
| Standard InChIKey | DGQLVPJVXFOQEV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C22H20O13/c1-4-8-5(2-6(24)9(4)22(33)34)13(25)10-11(15(8)27)16(28)12(18(30)17(10)29)21-20(32)19(31)14(26)7(3-23)35-21/h2,7,14,19-21,23-24,26,28-32H,3H2,1H3,(H,33,34) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Carmine is used in the manufacture of artificial flowers, paints, crimson ink, rouge, and other cosmetics, and is routinely added to food products such as yogurt, candy and certain brands of juice, the most notable ones being those of the ruby-red variety.There are many reported cases of immediate allergy after ingestion of foods containing cochineal and have a few reports of allergic contact dermatitis from carmine, suggests that carmine is an allergen. |
| In vivo | Allergic contact dermatitis from carmine in cosmetic blush.[Pubmed: 22653009]Dermatitis. 2011 Nov-Dec;22(6):348-9.Although there are many reported cases of immediate allergy after ingestion of foods containing cochineal, there are few reports of allergic contact dermatitis from Carmine. Effects of indigo carmine intravenous injection on noninvasive and continuous total hemoglobin measurement.[Pubmed: 26076807]J Clin Monit Comput. 2015 Jun 17.The effects of an intravenous injection of indigo Carmine on noninvasive and continuous total hemoglobin (SpHb) measurement were retrospectively evaluated. |
| Cell Research | Effects of indigo carmine on human chondrocytes in vitro.[Pubmed: 23341851]Open Orthop J. 2013;7:8-11.Joint infections following or accompanying superficious soft tissue infections are severe complication in orthopedic surgery. The use of intra-articular blue staining is a helpful method to visualize a fistula and to differentiate between superficial and intra-articular infections. Regarding this clinical implication data about the effects of indigo Carmine, a frequently used blue staining substance, on cartilage is missing. |
Carmine Dilution Calculator
Carmine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0309 mL | 10.1546 mL | 20.3091 mL | 40.6182 mL | 50.7728 mL |
| 5 mM | 0.4062 mL | 2.0309 mL | 4.0618 mL | 8.1236 mL | 10.1546 mL |
| 10 mM | 0.2031 mL | 1.0155 mL | 2.0309 mL | 4.0618 mL | 5.0773 mL |
| 50 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 0.8124 mL | 1.0155 mL |
| 100 mM | 0.0203 mL | 0.1015 mL | 0.2031 mL | 0.4062 mL | 0.5077 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effects of indigo carmine on human chondrocytes in vitro.[Pubmed:23341851]
Open Orthop J. 2013;7:8-11.
Joint infections following or accompanying superficious soft tissue infections are severe complication in orthopedic surgery. The use of intra-articular blue staining is a helpful method to visualize a fistula and to differentiate between superficial and intra-articular infections. Regarding this clinical implication data about the effects of indigo Carmine, a frequently used blue staining substance, on cartilage is missing. The hypothesis of this study was that indigo Carmine damages human chondrocytes in a time and concentration dependent manner. Human chondrocytes were isolated from donors with osteoarthritis who were treated with TKA. Cells were cultivated and treated with different concentrations of indigo Carmine for 5 and 10 minutes. Morphologic damage was examined by light microscopy. Toxicity was quantified by counting vital cell number and lactate dehydrogenase (LDH) expression. Analysis by light microscopy showed defected cell structure and loss of cell number after treatment with 100% indigo Carmine for 10 minutes. Treatment with 10% and 1% indigo Carmine showed no significant cell defects and loss of cells. Counting vital cell number showed loss of vital cells after treatment with 100% and 10% indigo Carmine for 10 minutes. LDH expression was significantly increased after treatment with 100% indigo Carmine.Toxic effects were shown after treatment with indigo Carmine. Therefore, it should be used in 1:100 dilution. This is both, sufficient for visualizing a fistula in a possible clinical application and could be protective for chondrocytes.
Effects of indigo carmine intravenous injection on noninvasive and continuous total hemoglobin measurement.[Pubmed:26076807]
J Clin Monit Comput. 2016 Jun;30(3):313-6.
The effects of an intravenous injection of indigo Carmine on noninvasive and continuous total hemoglobin (SpHb) measurement were retrospectively evaluated. The subjects were 21 patients who underwent elective gynecologic surgery under general anesthesia. During surgery, 5 mL of 0.4 % indigo Carmine was intravenously injected, and subsequent changes in SpHb concentrations were evaluated. The results demonstrate that the pre-injection SpHb level was 10 g/dL, and the minimum post-injection SpHb level was 8.3 g/dL. The amount of decrease was 1.8 g/dL. The time to reach the minimum value was 4 min, and the time to return to the pre-injection value was 15 min. The decrease in SpHb was greater in the group with a perfusion index (PI) < 1.4 than in the group with a PI > 1.4. The assessment of SpHb after an intravenous injection of indigo Carmine necessitates caution.
Allergic contact dermatitis from carmine in cosmetic blush.[Pubmed:22653009]
Dermatitis. 2011 Nov-Dec;22(6):348-9.
Although there are many reported cases of immediate allergy after ingestion of foods containing cochineal, there are few reports of allergic contact dermatitis from Carmine. We present a rare case of allergic contact dermatitis due to Carmine. A 52-year-old female presented with an itchy erythema on her cheeks at the site where blush had been applied. Patch-tested with her cosmetics, she showed a positive reaction to the blush (30% in petrolatum) and to 0.2% (but not 0.1%) Carmine in petrolatum. In this case, the optimum patch-test concentration of Carmine was 0.2% in petrolatum.
