4-Aminopyrazolo[3,4-d]pyrimidineCAS# 2380-63-4 |
![4-Aminopyrazolo[3,4-d]pyrimidine](/media/images/struct/BCC8690.png "4-Aminopyrazolo[3,4-d]pyrimidine")
Quality Control & MSDS
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3D structure
| Cas No. | 2380-63-4 | SDF | Download SDF |
| PubChem ID | 75420 | Appearance | Powder |
| Formula | C5H5N5 | M.Wt | 135 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1H-pyrazolo[3,4-d]pyrimidin-4-amine | ||
| SMILES | C1=NNC2=C1C(=NC=N2)N | ||
| Standard InChIKey | LHCPRYRLDOSKHK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
4-Aminopyrazolo[3,4-d]pyrimidine Dilution Calculator
4-Aminopyrazolo[3,4-d]pyrimidine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 7.4074 mL | 37.037 mL | 74.0741 mL | 148.1481 mL | 185.1852 mL |
| 5 mM | 1.4815 mL | 7.4074 mL | 14.8148 mL | 29.6296 mL | 37.037 mL |
| 10 mM | 0.7407 mL | 3.7037 mL | 7.4074 mL | 14.8148 mL | 18.5185 mL |
| 50 mM | 0.1481 mL | 0.7407 mL | 1.4815 mL | 2.963 mL | 3.7037 mL |
| 100 mM | 0.0741 mL | 0.3704 mL | 0.7407 mL | 1.4815 mL | 1.8519 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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6-Deoxy-6-[131I]iodo-L-ascorbic acid for the in vivo study of ascorbate: autoradiography, biodistribution in normal and hypolipidemic rats, and in tumor-bearing nude mice.[Pubmed:19881306]
Biol Pharm Bull. 2009 Nov;32(11):1906-11.
Normal female rat distribution studies showed high and specific uptake of 6-deoxy-6-[(131)I]iodo-L-ascorbic acid (6-(131)IAsA) into the adrenal glands, known to highly express the ascorbate sodium-dependent vitamin C transporter-2 (SVCT-2), and the adrenal gland was clearly visualized by whole-body autoradiography. Preinjection of sulfinpyrazone, a known blocker of ascorbate transport, with 6-(131)IAsA resulted in decreased uptake of radioactivity in rat adrenal glands compared to the control group, seemingly illustrating the participation of the SVCT transporter (probably the SVCT-2 subtype) in the uptake process in vivo. 4-Aminopyrazolo[3,4-d]pyrimidine-induced hypolipidemic rats showed a 1.7-fold increase in adrenal uptake of radioactivity at 30 min postinjection of 6-(131)IAsA, compared to the control, with increased adrenal-to-liver and adrenal-to-kidney ratios. To further characterize 6-(131)IAsA for its tumor uptake properties, biodistribution studies were also performed using male nude mice implanted with either Y-1 adrenocortical tumor cells or adrenal medulla-derived PC12 cells. None of these tumors exhibited relevant uptake of 6-(131)IAsA while normal adrenal glands showed high uptake of radioactivity, suggesting that these tumors in this model have only a poor transport capacity for this agent. The present study demonstrates that the use of radioiodinated 6-IAsA may help to obtain information about functional alterations in diseased adrenal glands, but it does not exhibit desirable properties as a tumor-seeking agent for ascorbic acid bioactivity.
