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13(18)-Oleanen-3-one

13(18)-Oleanen-3-one

Catalog No. BCN4887
Size Price Stock
20mg $298 In stock
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Quality Control of 13(18)-Oleanen-3-one

Chemical structure

13(18)-Oleanen-3-one

Biological Activity of 13(18)-Oleanen-3-one

1. 3(18)-Oleanen-3-one has anti-inflammatory effect, can inhibit IL-6, TNF-α and NO production, control the cyclooxygenase-2 (COX-2) regulation at protein levels.

13(18)-Oleanen-3-one Dilution Calculator

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13(18)-Oleanen-3-one Molarity Calculator

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Chemical Properties of 13(18)-Oleanen-3-one

Cas No. 20248-08-2 SDF Download SDF
Type of Compound Triterpenoids Appearance Cryst.
Formula C30H48O M.Wt 424.7
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 13(18)-Oleanen-3-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3546 mL 11.773 mL 23.546 mL 47.0921 mL 58.8651 mL
5 mM 0.4709 mL 2.3546 mL 4.7092 mL 9.4184 mL 11.773 mL
10 mM 0.2355 mL 1.1773 mL 2.3546 mL 4.7092 mL 5.8865 mL
50 mM 0.0471 mL 0.2355 mL 0.4709 mL 0.9418 mL 1.1773 mL
100 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.4709 mL 0.5887 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 13(18)-Oleanen-3-one

This product is isolated and purified from the herbs of Euphorbia supina

References on 13(18)-Oleanen-3-one

δ-Amyrone, a specific inhibitor of cyclooxygenase-2, exhibits anti-inflammatory effects in vitro and in vivo of mice.[Pubmed: 24813716]


δ-Amyrone (13(18)-Oleanen-3-one), a pentacyclic triterpene compound from S. lineare Thunb, was found to possess a potent anti-inflammatory effect in different inflammation model animals. Pretreatment with 13(18)-Oleanen-3-one (i.p.) inhibited the ear edema in xylene-induced mouse ear edema. 13(18)-Oleanen-3-one also decreased the level of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6) and leukocyte numbers in acetic acid-induced peritonitis in vivo. To clarify the possible mechanism of 13(18)-Oleanen-3-one, we investigated the effect of 13(18)-Oleanen-3-one in lipopolysaccharide (LPS) induced peritoneal macrophages. The data indicated that 13(18)-Oleanen-3-one notably inhibited IL-6, TNF-α and NO production. In addition, the result showed that 13(18)-Oleanen-3-one may control the cyclooxygenase-2 (COX-2) regulation and not the cyclooxygenase-1 (COX-1) at protein levels. These results suggest that 13(18)-Oleanen-3-one is a bioactive agent which possesses anti-inflammatory effects, which may be relevant to the regulation of COX-2.

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13(18)-Oleanen-3-one ,20248-08-2,Nature Products, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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