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1,2-Dihydrotanshinquinone

1,2-Dihydrotanshinquinone

Catalog No. BCN2477
Size Price Stock
20mg $298 In stock
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Quality Control of 1,2-Dihydrotanshinquinone

Chemical structure

1,2-Dihydrotanshinquinone

1,2-Dihydrotanshinquinone Dilution Calculator

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1,2-Dihydrotanshinquinone Molarity Calculator

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Chemical Properties of 1,2-Dihydrotanshinquinone

Cas No. 77769-21-2 SDF Download SDF
Chemical Name 1,6-dimethyl-8,9-dihydronaphtho[8,7-g][1]benzoxole-10,11-dione
SMILES Cc1coc-2c1C(=O)C(=O)c3c2ccc4c3CCC=C4C
Standard InChIKey OYOSADAKNZWZGA-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h4,6-8H,3,5H2,1-2H3
Type of Compound Diterpenoids Appearance Red powder
Formula C18H14O3 M.Wt 278.3
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of 1,2-Dihydrotanshinquinone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of 1,2-Dihydrotanshinquinone

This product is isolated and purified from the roots of Salvia miltiorrhiza Bge.

References on 1,2-Dihydrotanshinquinone

Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.[Pubmed: 21412700 ]


In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic methods (PDA, -MS (n), HR-MS, microprobe NMR), the active compounds were identified as tanshinone-type diterpenoids. Subsequent isolation and structure elucidation yielded the known substances miltirone (1), tanshinone II a (2), 1,2-Dihydrotanshinquinone(3), methylenetanshinquinone (4), 1-oxomiltirone (5), 11-hydroxymiltiodiol (6), tanshinone I (7), methyltanshinonate (8), and cryptotanshinone (9). The IC₅₀s of the compounds were determined against the two parasites and rat myoblast (L6) cells. They ranged from 4.1 μM to over 30 μM against P. falciparum K1 strain with selectivity indices (SI) from 0.3 to 1.9. IC₅₀s against T. brucei rhodesiense STIB 900 were from 0.5 μM (1, 4) to over 30 μM, and 4 showed the greatest selective activity with an SI of 24.

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