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(24R)-MC 976Vitamin D3 derivative

(24R)-MC 976

Catalog No. BCC1289
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1mg $925.00 Please Inquire
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Chemical structure

(24R)-MC 976

(24R)-MC 976 Dilution Calculator

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(24R)-MC 976 Molarity Calculator



Chemical Properties of (24R)-MC 976

Cas No. 112828-09-8 SDF Download SDF
Chemical Name (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-cyclopropyl-5-hydroxypentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Standard InChI InChI=1S/C27H42O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h7,10,17,20,22-26,28-30H,2,4-6,8-9,11-16H2,1,3H3/b19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1
Formula C27H42O3 M.Wt 414.62
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (24R)-MC 976

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4118 mL 12.0592 mL 24.1185 mL 48.2369 mL 60.2962 mL
5 mM 0.4824 mL 2.4118 mL 4.8237 mL 9.6474 mL 12.0592 mL
10 mM 0.2412 mL 1.2059 mL 2.4118 mL 4.8237 mL 6.0296 mL
50 mM 0.0482 mL 0.2412 mL 0.4824 mL 0.9647 mL 1.2059 mL
100 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.4824 mL 0.603 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Background on (24R)-MC 976

MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3). Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model (Hep 3B), leading to identify the 24 (R) alcohols metabolite of MC 969, (24R)-MC 976.
In vitro: Metabolic study of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. It was found that unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites (24 (R,S) alcohols of MC 969) was provided. In the competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than lα-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed [1].
In vivo: No animal in-vivo data available currently.
Clinical trial: (24R)-MC 976 is currently in the preclinical developlent stage and no clinical data are available.
[1] Strugnell S, Calverley MJ, Jones G. Metabolism of a cyclopropane-ring-containing analog of 1 alpha-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochem Pharmacol. 1990;40(2):333-41.


(24R)-MC 976,112828-09-8,Vitamin D Related,VD/VDR, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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