Products with Vasoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5601 | Chrysoeriol |
| 1. Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. 2. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. 3. Chrysoeriol can potentially serve as a novel cardioprotective agent against doxorubicin (DOX)-induced cardiotoxicity without affecting the antitumor activity of DOX. 4. Chrysoeriol can induce nod genes in rhizobium meliloti. 5. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases and during restenosis after coronary angioplasty. 6. Chrysoeriol can protect MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. | |
| BCN5654 | Hesperidin |
| Hesperidin has antioxidative, anti-inflammatory, vasoprotective,and anticarcinogenic effects, it induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Hesperidin also exerts its protective effect against CYP-induced hepatotoxicity through upregulation of hepatic PPARγ expression and abrogation of inflammation and oxidative stress. | |
| BCN5944 | Liquiritin |
| Liquiritin possesses antidepressant-like, neuroprotective , antioxidant, antiapoptosis, anti-inflammatory and anti-cancer abilities. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients. | |
| BCN5951 | Salvianolic acid A |
| Salvianolic acid A has antioxidant, hepatoprotective, antithrombotic effect, and antiplatelet actions. it also has a significant protective effect against isoproterenol-induced myocardial infarction; it activates the Nrf2/HO-1 axis in RPE cells and protects against oxidative stress via activation of Akt/mTORC1 signaling. Salvianolic acid A (oral) can significantly improve glucose metabolism and inhibit oxidative injury as well as protect against impaired vascular responsiveness in STZ-induced diabetic rats. It is a novel matrix metalloproteinase-9 inhibitor, can prevents cardiac remodeling in spontaneously hypertensive rats. | |
| BCN6790 | Dehydroglyasperin C |
| 1. Dehydroglyasperin C exhibits cancer chemopreventive potential via its inhibitory effect on TPA-induced neoplastic cell transformation and COX-2 modulation through regulation of the MKK4 and PI3K pathways. 2. Dehydroglyasperin C may inhibit microglia hyperactivation by increasing MKP-1 expression and acting as a potent anti-neurodegenerative agent. 3. Dehydroglyasperin C possesses potent antioxidant activity, suggests that it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. 4. Dehydroglyasperin C can attenuate proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. 5. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways. 6. Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. | |
