FAAH

Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

Products for FAAH

  1. Cat.No. Product Name Information
  2. BCC1718 LY2183240FAAH inhibitor; also inhibits anandamide uptake
  3. BCC1851 PF-04457845FAAH inhibitor,potent and exquisitely selective
  4. BCC2315 JNJ-1661010Selective, reversible FAAH inhibitor
  5. BCC2324 URB597Potent and selective FAAH inhibitor
  6. BCC2326 PF-3845Selective FAAH inhibitor
  7. BCC4254 FAAH inhibitor 1
  8. BCC5609 TAK 21dPotent FAAH inhibitor

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