SalvioloneCAS# 119400-86-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 119400-86-1 | SDF | Download SDF |
| PubChem ID | 10355691 | Appearance | Yellow cryst. |
| Formula | C18H20O2 | M.Wt | 268.4 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-hydroxy-4,4,8-trimethyl-2,3-dihydro-1H-cyclohepta[a]naphthalen-10-one | ||
| SMILES | CC1=C(C(=O)C=C2C3=C(C=CC2=C1)C(CCC3)(C)C)O | ||
| Standard InChIKey | QATRODNHXVHGNU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H20O2/c1-11-9-12-6-7-15-13(5-4-8-18(15,2)3)14(12)10-16(19)17(11)20/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Salvia miltiorrhiza
| Description | 1. Salviolone exhibits cytotoxic activity against Vero cells. 2. Salviolone has a benzotropolone moiety has been isolated together with two other nor- and bisnorditerpenes 1 and 2 from the fresh root . |
Salviolone Dilution Calculator
Salviolone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7258 mL | 18.6289 mL | 37.2578 mL | 74.5156 mL | 93.1446 mL |
| 5 mM | 0.7452 mL | 3.7258 mL | 7.4516 mL | 14.9031 mL | 18.6289 mL |
| 10 mM | 0.3726 mL | 1.8629 mL | 3.7258 mL | 7.4516 mL | 9.3145 mL |
| 50 mM | 0.0745 mL | 0.3726 mL | 0.7452 mL | 1.4903 mL | 1.8629 mL |
| 100 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.7452 mL | 0.9314 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway.[Pubmed:30610802]
J BUON. 2018 Nov-Dec;23(6):1739-1744.
PURPOSE: Cervical cancer is one of the prevalently diagnosed cancers in women worldwide. In this study the antiproliferative and anticancer effects of Salviolone were evaluated against HeLa cervical cancer cell line along with determining the anticancer mode of action. METHODS: MTT assay was employed to examine the proliferation rate of HeLa cells. Transmission electron microscopy (TEM) was used for the detection of the autophagic cell death. The cell invasion and migration were investigated by transwell assay and the expression of the proteins was estimated by western blotting. RESULTS: The results revealed that Salviolone exerts anticancer effects on the HeLa cells with an IC50 of 20 microM. The effect of Salviolone on the viability of normal FR-2 cells was very low. TEM analysis showed that Salviolone triggers autophagic cell death in HeLa cells. Salviolone could also cause arrest of the HeLa cervical cancer cells in the G2/M phase of the cell cycle and suppress their ability to migrate and invade. Western blotting analysis revealed that Salviolone could inhibit the of Nf-kB/m-TOR/PI3K/AKT signalling pathway in HeLa cells. CONCLUSION: Taken all together, it is concluded that Salviolone could prove to be an important lead molecule for the treatment of cervical cancer.
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