Kuraridine

CAS# 34981-25-4

Kuraridine

Catalog No. BCN2988----Order now to get a substantial discount!

Product Name & Size Price Stock
Kuraridine: 5mg $811 In Stock
Kuraridine: 10mg Please Inquire In Stock
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Quality Control of Kuraridine

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Chemical structure

Kuraridine

3D structure

Chemical Properties of Kuraridine

Cas No. 34981-25-4 SDF Download SDF
PubChem ID 9954815 Appearance Yellow powder
Formula C26H30O6 M.Wt 438.5
Type of Compound Chalcones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-1-[2,4-dihydroxy-6-methoxy-3-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
SMILES CC(=CCC(CC1=C(C=C(C(=C1O)C(=O)C=CC2=C(C=C(C=C2)O)O)OC)O)C(=C)C)C
Standard InChIKey PIAPWPAWQGDOMN-PKNBQFBNSA-N
Standard InChI InChI=1S/C26H30O6/c1-15(2)6-7-18(16(3)4)12-20-23(30)14-24(32-5)25(26(20)31)21(28)11-9-17-8-10-19(27)13-22(17)29/h6,8-11,13-14,18,27,29-31H,3,7,12H2,1-2,4-5H3/b11-9+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kuraridine

The roots of Sophora flavescens

Biological Activity of Kuraridine

Description1. Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
TargetsPDE

Kuraridine Dilution Calculator

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Kuraridine Molarity Calculator

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Preparing Stock Solutions of Kuraridine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2805 mL 11.4025 mL 22.805 mL 45.61 mL 57.0125 mL
5 mM 0.4561 mL 2.2805 mL 4.561 mL 9.122 mL 11.4025 mL
10 mM 0.2281 mL 1.1403 mL 2.2805 mL 4.561 mL 5.7013 mL
50 mM 0.0456 mL 0.2281 mL 0.4561 mL 0.9122 mL 1.1403 mL
100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4561 mL 0.5701 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Kuraridine

A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.[Pubmed:12161123]

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.

During the search for naturally occurring cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitors, it was found that the extracts from Sophora flavescens exhibit potent inhibitory activity against cGMP PDE5 prepared from rat diaphragm. Therefore, the inhibitory activities of five flavonoids, kushenol H (1), kushenol K (2), kurarinol (3), sophoflavescenol (4) and Kuraridine (5), isolated from S. flavescens were measured against cGMP PDE5 to identify potent cGMP PDE5 inhibitory constituents. Among tested compounds, sophoflavescenol (4), a C-8 prenylated flavonol, showed the most potent inhibitory activity (IC(50)=0.013 microM) against cGMP PDE5 with 31.5- and 196.2-fold selectivity over PDE3 and PDE4, respectively. Kinetic analysis revealed that sophoflavescenol was a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM.

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