Kongensin ACAS# 885315-96-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 885315-96-8 | SDF | Download SDF |
| PubChem ID | 91895304 | Appearance | Powder |
| Formula | C22H30O5 | M.Wt | 374.5 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC(=O)OC1CCC(C2C1(C(=O)CCC3C=C(C(C2)O)C(=O)C3=C)C)(C)C | ||
| Standard InChIKey | NUUWPMNNBHROPI-ASAQZKIWSA-N | ||
| Standard InChI | InChI=1S/C22H30O5/c1-12-14-6-7-18(25)22(5)17(11-16(24)15(10-14)20(12)26)21(3,4)9-8-19(22)27-13(2)23/h10,14,16-17,19,24H,1,6-9,11H2,2-5H3/t14-,16-,17-,19-,22-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Croton cascarilloides
| Description | 1. Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications. |
| Targets | HSP (e.g. HSP90) |
Kongensin A Dilution Calculator
Kongensin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6702 mL | 13.3511 mL | 26.7023 mL | 53.4045 mL | 66.7557 mL |
| 5 mM | 0.534 mL | 2.6702 mL | 5.3405 mL | 10.6809 mL | 13.3511 mL |
| 10 mM | 0.267 mL | 1.3351 mL | 2.6702 mL | 5.3405 mL | 6.6756 mL |
| 50 mM | 0.0534 mL | 0.267 mL | 0.534 mL | 1.0681 mL | 1.3351 mL |
| 100 mM | 0.0267 mL | 0.1335 mL | 0.267 mL | 0.534 mL | 0.6676 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- W-13 hydrochloride
Catalog No.:BCC6620
CAS No.:88519-57-7
- Rosamultin
Catalog No.:BCN7391
CAS No.:88515-58-6
- LY 2389575 hydrochloride
Catalog No.:BCC7985
CAS No.:885104-09-6
- GW9508
Catalog No.:BCC1102
CAS No.:885101-89-3
- Dichotomitin
Catalog No.:BCN8524
CAS No.:88509-91-5
- ARRY 520 trifluoroacetate
Catalog No.:BCC2391
CAS No.:885060-09-3
- ARRY-520 R enantiomer
Catalog No.:BCC1368
CAS No.:885060-08-2
- Benzotetramisole
Catalog No.:BCC8861
CAS No.:885051-07-0
- Farrerol 7-O-glucoside
Catalog No.:BCN6412
CAS No.:885044-12-2
- Manassantin A
Catalog No.:BCC8207
CAS No.:88497-87-4
- Artesunate
Catalog No.:BCN2457
CAS No.:88495-63-0
- Murraxocin
Catalog No.:BCN4431
CAS No.:88478-44-8
New Products
- MK-8745
Catalog No.:BCC3994
CAS No.:885325-71-3
- HJC 0350
Catalog No.:BCC6302
CAS No.:885434-70-8
- Minumicrolin
Catalog No.:BCN4433
CAS No.:88546-96-7
- CCT128930
Catalog No.:BCC3904
CAS No.:885499-61-6
- 5'-O-Acetyljuglanin
Catalog No.:BCN6846
CAS No.:885697-82-5
- c-FMS inhibitor
Catalog No.:BCC1472
CAS No.:885704-21-2
- Fmoc-ε-Acp-OH
Catalog No.:BCC3206
CAS No.:88574-06-5
- Isomexoticin
Catalog No.:BCN4434
CAS No.:88585-86-8
- LY2119620
Catalog No.:BCC5564
CAS No.:886047-22-9
- Chrysin 7-O-beta-gentiobioside
Catalog No.:BCN2943
CAS No.:88640-89-5
- Cerebroside B
Catalog No.:BCN4435
CAS No.:88642-46-0
- Apogossypolone (ApoG2)
Catalog No.:BCC2237
CAS No.:886578-07-0
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.[Pubmed:27028885]
Cell Chem Biol. 2016 Feb 18;23(2):257-266.
RIP3-dependent necroptosis has recently garnered significant interest because of the unique signaling mechanisms and pathologic functions involved in this process. Accordingly, a number of chemical screens have identified several effective small-molecule inhibitors that specifically block necroptosis. Here, we report the discovery that Kongensin A (KA), a natural product isolated from Croton kongensis, is a potent inhibitor of necroptosis and an inducer of apoptosis. Using a new bioorthogonal ligation method (TQ ligation), we reveal that the direct cellular target of KA is heat shock protein 90 (HSP90). Further studies demonstrate that KA covalently binds to a previously uncharacterized cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37, which leads to inhibition of RIP3-dependent necroptosis and promotion of apoptosis in multiple cancer cell lines. Collectively, our findings demonstrate that KA is an effective HSP90 inhibitor that has potential anti-necroptosis and anti-inflammation applications.
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.
Kongensin A,885315-96-8,Natural Products, buy Kongensin A , Kongensin A supplier , purchase Kongensin A , Kongensin A cost , Kongensin A manufacturer , order Kongensin A , high purity Kongensin A
