HexestrolCAS# 84-16-2 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 84-16-2 | SDF | Download SDF |
| PubChem ID | 3606 | Appearance | Powder |
| Formula | C18H22O2 | M.Wt | 270.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 4-[4-(4-hydroxyphenyl)hexan-3-yl]phenol | ||
| SMILES | CCC(C1=CC=C(C=C1)O)C(CC)C2=CC=C(C=C2)O | ||
| Standard InChIKey | PBBGSZCBWVPOOL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Hexestrol Dilution Calculator
Hexestrol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6986 mL | 18.4932 mL | 36.9864 mL | 73.9727 mL | 92.4659 mL |
| 5 mM | 0.7397 mL | 3.6986 mL | 7.3973 mL | 14.7945 mL | 18.4932 mL |
| 10 mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 7.3973 mL | 9.2466 mL |
| 50 mM | 0.074 mL | 0.3699 mL | 0.7397 mL | 1.4795 mL | 1.8493 mL |
| 100 mM | 0.037 mL | 0.1849 mL | 0.3699 mL | 0.7397 mL | 0.9247 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
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Assessing placental corticotrophin-releasing hormone disruption by hexestrol in a cell model.[Pubmed:27816005]
Environ Toxicol Pharmacol. 2016 Dec;48:197-202.
Studies have shown that corticotrophin-releasing hormone (CRH) and relaxin are associated with early delivery. Our lab previously has shown the mycotoxin zeranol increases placental CRH expression. The mycotoxin is used in the farming industry to promote cattle growth, and some synthetic hormones are also used for the same purposes. In order to complete the picture of these growth promoting agents, we attempted to examine the synthetic hormones on the placental gene expression in the current study. Among the tested compounds, Hexestrol induced the CRH mRNA and protein expression at 100nM in JEG-3 cells. As signal transduction pathways have been described in the transcriptional control previously, the activations of several protein kinases were determined. P38, PKCbeta and JNK were activated upon Hexestrol treatment. Since the P38-inhibitor SB203580 prevented Hexestrol from inducing CRH in a subsequent experiment, P38 was likely involved in the transcriptional regulation. Electrophoretic mobility shift assay revealed an increase in the CRE binding activity in CRH promoter. This study showed that Hexestrol exposure might be a concern for pregnant women.
Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products.[Pubmed:24636894]
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:7-13.
A sensitive analytical method based on packed-fiber solid-phase extraction and high performance liquid chromatography-tandem mass spectrometry (PF SPE-HPLC-MS/MS) has been developed for determination of three synthetic stilbenes in milk. The stilbenes are extracted with acetonitrile, using sodium chloride, and purified with PF SPE using a cartridge containing electrospun polystyrene nanofibers. Parameters affecting the efficiency of PF SPE, such as pH and amount of salt, were optimized. Under optimal conditions, the limits of detection and quantification were 5-13pg/g and 15-37pg/g, respectively. Absolute recoveries varied between 60% and 85% at three different levels. The method was successfully applied for the determination of estrogenic stilbenes in a total of 69 milk samples. The method is sensitive and cost-effective in stilbene detection, and has potential in quality control of dairy products.
Hexestrol- and nonylphenol-induced differential vitellogenin synthesis in female and male barfin plaice Liopsetta pinnifasciata.[Pubmed:25682006]
Environ Toxicol Pharmacol. 2015 Mar;39(2):597-605.
The effects of Hexestrol (HXS) and nonylphenol (NP) on plasma vitellogenin (Vtg) concentration in barfin plaice Liopsetta pinnifasciata was studied during spring and autumn experiment. In L. pinnifasciata two "complete" forms of Vtgs, namely VtgAa and VtgAb, were previously described which may be separated due to molecular mass of their largest polypeptide in SDS-PAGE. In spring, the injection of HXS led to an increase in Vtg concentrations in both females and males. SDS-PAGE analysis of plasma from HXS-exposed fish produced only one prominent band at a molecular mass of 180 kDa that corresponds to an increase in VtgAb levels. NP injected in fish in spring induced statistically significant increasing of Vtg concentration in males, and only one type of Vtg, as in case of HXS, accumulated in plasma. In autumn, the injection of HXS results to the increase of Vtg concentration in the plasma of females and males, electrophoretic analysis of plasma proteins showed that only a 98 kDa polypeptide, corresponding to the VtgAa-type showed a significant increase. The blood plasma ratios of VtgAa and VtgAb in experimental fish are discussed in relation to the season and stage of reproductive cycle.
Electrochemical fabrication of polymerized imidazole-based ionic liquid bearing pyrrole moiety for sensitive determination of hexestrol in chicken meat.[Pubmed:25766811]
Food Chem. 2015 Aug 1;180:142-149.
1-[3-(tert-Butoxycarbonylamino)propyl]-3-[3-(N-pyrrole)propyl]imidazolium tetrafluoroborate [(t-Boc-APPPI)BF4], which is a novel pyrrolyl-functionalized ionic liquid, was synthesized and characterized. Subsequently, it was electrochemically deposited onto a glassy carbon electrode surface to fabricate a polymerized ionic liquid film electrode. X-ray photoelectron spectroscopy, scanning electron microscope and electrochemical impedance spectroscopy were used to confirm the successful polymerization of ionic liquid. Voltammetric behaviors of Hexestrol at the film electrode were investigated. The oxidation peak slightly shifted towards positive potential, however, dramatically increased in peak current. Experimental conditions for Hexestrol determination were optimized. The oxidation peak current is linear with Hexestrol concentration in the range of 1.0 x 10(-8)-1.0 x 10(-5) mol L(-1). The detection limit is estimated to be 2.1 x 10(-9) mol L(-1) (S/N=3). Hexestrol in chicken meat was determined using the film electrode with good accuracy.
