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Epimagnolin A

CAS# 41689-51-4

Epimagnolin A

Catalog No. BCN7831----Order now to get a substantial discount!

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Quality Control of Epimagnolin A

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Chemical structure

Epimagnolin A

3D structure

Chemical Properties of Epimagnolin A

Cas No. 41689-51-4 SDF Download SDF
PubChem ID 13889713 Appearance Powder
Formula C23H28O7 M.Wt 416.46
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,3aR,6R,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
SMILES COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)OC)OC)OC
Standard InChIKey MFIHSKBTNZNJIK-FRMGNDQPSA-N
Standard InChI InChI=1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3/t15-,16-,21+,22-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epimagnolin A

The dried flower buds of Magnolia biondii Pamp.

Biological Activity of Epimagnolin A

DescriptionEpimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily), it also exhibits growth inhibitory activity against larvae of Drosophila melanogaster.
TargetsATPase | ABCB1
In vitro

An insect growth inhibitory lignan from flower buds of Magnolia fargesii.[Reference: WebLink]

Phytochemistry, 1994, 35(00):611–613.

Bioassay-guided isolation afforded a new lignan, (+)-Epimagnolin A, from the flower buds of Magnolia fargesii. This lignan exhibited growth inhibitory activity against larvae of Drosophila melanogaster. The structure of a new lignan was determined on the basis of spectral methods.

Protocol of Epimagnolin A

Kinase Assay

Preparation of epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia sp., and evaluation of anti-drug-resistance activity.[Reference: WebLink]

Planta Med 2016; 82(S 01): S1-S381.

Herbal products have been used to treat or prevent health problems for a long time. Although the biological effects of these products have been reported, their safety still remains to be elucidated. Therefore, studies are required to ensure their safe use. Among the herbal products listed in the Korean, Chinese, and Japanese Pharmacopoeias, Shin-i (Xin-yi/Flos magnoliae), dried flower buds of Magnolia fargesii or M. flos are one of the most commonly used traditional herbs for the treatment of allergic rhinitis, emphysema, headache, nasal congestion, and sinusitis. Tetrahydrofurofuranoid lignans, such as aschantin, dimethoxyaschantin, dimethylliroresinol, dimethylpinoresinol, Epimagnolin A, fargesin, and magnolin extracted from Shin-i have effects, such as anti-angiogenic, anti-allergic, anti-diabetic, anti-inflammatory, anti-microbial, and anti-rheumatoid arthritis. Among them, the pharmacokinetics of Epimagnolin A and magnolin have been reported, but not their molecular mechanisms.
METHODS AND RESULTS:
We examined the possibility of interaction between Epimagnolin A and human multidrug resistance protein ABCB1, a major transmembrane efflux pump belonging to the ABC transporter superfamily. In the calcein and ATPase assay [1], Epimagnolin A inhibited the extrusion of calcein by Flp-In-293/ABCB1 cells and stimulated the ATPase activity of ABCB1, respectively, in a concentration-dependent manner. It showed saturation kinetics between compound-stimulated ATPase activity and compound concentration, suggesting Michaelis-Menten kinetics similar to control drug, verapamil. The Km and Vmax values were calculated from Hanes-Woolf plots; epimagnolin, Km = 42.9 ± 7.53µM and Vmax = 156 ± 15.0µM and verapamil, Km = 12.3 ± 4.79µM and Vmax = 109 ± 3.18µM. In the MTT assay, the sensitivities of the Flp-In-293/ABCB1 cells to anti-cancer drugs were enhanced in the presence of 10µM Epimagnolin A.
CONCLUSIONS:
The present study results indicate that Epimagnolin A affects the transport activity of ABCB1.

Structure Identification
J Sep Sci. 2007 Oct;30(15):2370-81.

Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction.[Pubmed: 17628872]

The dried flower buds of Magnolia biondii Pamp are one of the most widely used medicinal plants officially listed in the Chinese Pharmacopoeia.
METHODS AND RESULTS:
A 2-D column-switching system without sample loop trapping, where two columns were switched directly via a six-port two-position switching valve, was successfully applied for the first time to the isolation and purification of five lignans including pinoresinol dimethyl ether, magnolin, epi-magnolin A, fargesin, and demethoxyaschantin from M. biondii Pamp after microwave-assisted extraction. The introduction of the six-port switching valve instead of sample loop assured 100% recovery from the first dimension to the second, and the injection volumes of the second dimension could reach 12 mL.
CONCLUSIONS:
In this mode of operation, the solvent consumption of the 2-D approach was less than 30% that of conventional gradient methods with even larger sample size. The simultaneous operations of the two dimensions allowed the cycle time to be less than 16 min, compared to 90 min in the gradient elution single-dimension mode of operation. All of the five lignans were isolated at high purities of over 99% with approximately 95% recoveries.

Epimagnolin A Dilution Calculator

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Epimagnolin A Molarity Calculator

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Preparing Stock Solutions of Epimagnolin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4012 mL 12.006 mL 24.0119 mL 48.0238 mL 60.0298 mL
5 mM 0.4802 mL 2.4012 mL 4.8024 mL 9.6048 mL 12.006 mL
10 mM 0.2401 mL 1.2006 mL 2.4012 mL 4.8024 mL 6.003 mL
50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9605 mL 1.2006 mL
100 mM 0.024 mL 0.1201 mL 0.2401 mL 0.4802 mL 0.6003 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Epimagnolin A

Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction.[Pubmed:17628872]

J Sep Sci. 2007 Oct;30(15):2370-81.

The dried flower buds of Magnolia biondii Pamp are one of the most widely used medicinal plants officially listed in the Chinese Pharmacopoeia. A 2-D column-switching system without sample loop trapping, where two columns were switched directly via a six-port two-position switching valve, was successfully applied for the first time to the isolation and purification of five lignans including pinoresinol dimethyl ether, magnolin, epi-magnolin A, fargesin, and demethoxyaschantin from M. biondii Pamp after microwave-assisted extraction. The introduction of the six-port switching valve instead of sample loop assured 100% recovery from the first dimension to the second, and the injection volumes of the second dimension could reach 12 mL. In this mode of operation, the solvent consumption of the 2-D approach was less than 30% that of conventional gradient methods with even larger sample size. The simultaneous operations of the two dimensions allowed the cycle time to be less than 16 min, compared to 90 min in the gradient elution single-dimension mode of operation. All of the five lignans were isolated at high purities of over 99% with approximately 95% recoveries.

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