DehydroandrographolidesuccinateCAS# 786593-06-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 786593-06-4 | SDF | Download SDF |
| PubChem ID | 6540717 | Appearance | White crystalline powder |
| Formula | C28H36O10 | M.Wt | 532.582 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (469.41 mM; Need ultrasonic) | ||
| Chemical Name | 4-[[(1R,2R,4aR,5R,8aS)-2-(3-carboxypropanoyloxy)-1,4a-dimethyl-6-methylidene-5-[(E)-2-(5-oxo-2H-furan-4-yl)ethenyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methoxy]-4-oxobutanoic acid | ||
| SMILES | CC12CCC(C(C1CCC(=C)C2C=CC3=CCOC3=O)(C)COC(=O)CCC(=O)O)OC(=O)CCC(=O)O | ||
| Standard InChIKey | YTHKMAIVPFVDNU-GPTWTFMPSA-N | ||
| Standard InChI | InChI=1S/C28H36O10/c1-17-4-7-20-27(2,19(17)6-5-18-13-15-36-26(18)35)14-12-21(38-25(34)11-9-23(31)32)28(20,3)16-37-24(33)10-8-22(29)30/h5-6,13,19-21H,1,4,7-12,14-16H2,2-3H3,(H,29,30)(H,31,32)/b6-5+/t19-,20+,21-,27+,28+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. It combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly. |
| Targets | NOS | TNF-α | IL recepter | SOD | Antifection |
| In vivo | Therapeutic effects of dehydroandrographolide succinate combined with ribavirin on children with hand-foot-and-mouth disease[Reference: WebLink]Anhui Medical Journal, 2010. To evaluate the therapeutic effects of Dehydroandrographolide succinate and ribavirin on children with the early severe tendencies of hand-foot-and-mouth disease. |
| Animal Research | Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS.[Pubmed: 22985554]Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.To investigate the effect of Dehydroandrographolide succinate (DAS) on oxidative stress and induced nitric oxide synthase (iNOS) expression in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury.
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Dehydroandrographolidesuccinate Dilution Calculator
Dehydroandrographolidesuccinate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.8776 mL | 9.3882 mL | 18.7765 mL | 37.5529 mL | 46.9411 mL |
| 5 mM | 0.3755 mL | 1.8776 mL | 3.7553 mL | 7.5106 mL | 9.3882 mL |
| 10 mM | 0.1878 mL | 0.9388 mL | 1.8776 mL | 3.7553 mL | 4.6941 mL |
| 50 mM | 0.0376 mL | 0.1878 mL | 0.3755 mL | 0.7511 mL | 0.9388 mL |
| 100 mM | 0.0188 mL | 0.0939 mL | 0.1878 mL | 0.3755 mL | 0.4694 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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