DUBs-IN-1

CAS# 924296-18-4

DUBs-IN-1

Catalog No. BCC5256----Order now to get a substantial discount!

Product Name & Size Price Stock
DUBs-IN-1:1mg $150.00 In stock
DUBs-IN-1:2mg $255.00 In stock
DUBs-IN-1:5mg $600.00 In stock
DUBs-IN-1:10mg $1050.00 In stock
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Quality Control of DUBs-IN-1

Quality Control & MSDS

Number of papers citing our products

Chemical structure

DUBs-IN-1

3D structure

Chemical Properties of DUBs-IN-1

Cas No. 924296-18-4 SDF Download SDF
PubChem ID 16065490 Appearance Powder
Formula C20H11N5O M.Wt 337.33
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 100 mg/mL (296.45 mM; Need ultrasonic)
Chemical Name (9E)-9-phenylmethoxyiminoindeno[1,2-b]pyrazine-2,3-dicarbonitrile
SMILES C1=CC=C(C=C1)CON=C2C3=CC=CC=C3C4=NC(=C(N=C42)C#N)C#N
Standard InChIKey GKOWDIBLCDZJHF-NCELDCMTSA-N
Standard InChI InChI=1S/C20H11N5O/c21-10-16-17(11-22)24-20-18(23-16)14-8-4-5-9-15(14)19(20)25-26-12-13-6-2-1-3-7-13/h1-9H,12H2/b25-19+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

DUBs-IN-1 Dilution Calculator

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DUBs-IN-1 Molarity Calculator

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Preparing Stock Solutions of DUBs-IN-1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9645 mL 14.8223 mL 29.6446 mL 59.2891 mL 74.1114 mL
5 mM 0.5929 mL 2.9645 mL 5.9289 mL 11.8578 mL 14.8223 mL
10 mM 0.2964 mL 1.4822 mL 2.9645 mL 5.9289 mL 7.4111 mL
50 mM 0.0593 mL 0.2964 mL 0.5929 mL 1.1858 mL 1.4822 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.5929 mL 0.7411 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

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Background on DUBs-IN-1

DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8.

In Vitro:DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1].

References:
[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

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Description

DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8.

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